Clinical application of an enzyme‐linked immunosorbent assay detecting hepatoma‐specific γ‐glutamyltransferase

Wang, Nianyue; Zhang, Dai; Zhao, Wei; Fang, Guo-Xiang; Shi, Yujun; Duan, Mu-Hao

doi:10.1111/j.1872-034x.2009.00538.x

Cited by 9 publications

(9 citation statements)

References 32 publications

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“…The reason for this is not clear, although both groups had low AFP values compared to most larger tumor patients. High AST levels are also reported as a poor prognostic factor (29) as have GGTP levels (30, 31); however survival data was not available for this cohort. The correlation matrix showed a significant correlation for platelets with tumor size, but less of a correlation with tumor number or presence of PVT.…”

Section: Discussionmentioning

confidence: 95%

Platelet-Related Phenotypic Patterns in Hepatocellular Carcinoma Patients

Carr

Lin

2014

Seminars in Oncology

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Background Small HCCs usually arise in cirrhosis, often with associated thrombocytopenia. Many large HCC patients have normal blood platelet counts. Aims To compare parameter and phenotype patterns of patients with small ≤3cm and larger HCCs. Methods Retrospective analysis was undertaken of a 4139 patient HCC database to compare patient demographics, liver and tumor characteristics associated with small and large size HCCs, especially with respect to platelet counts. Results Patients with larger HCCs had more tumor nodules and PVT positivity, and had higher blood AFP, bilirubin and platelet counts. In patients with larger tumors and normal platelets (43.7% of the cohort), tumors were larger and AFP levels were higher, with lower bilirubin and AST levels than in patients with larger tumors and thrombocytopenia (17.5%). A parsimonious multinomial regression model showed high Odds Ratio for AFP and platelets for tumors >3cm with PVT. Conclusions Platelet levels are associated with distinct large HCC phenotypes.

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Section: Discussionmentioning

confidence: 95%

Platelet-Related Phenotypic Patterns in Hepatocellular Carcinoma Patients

Carr

Lin

2014

Seminars in Oncology

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“…A second possibility is that the liver parameters actually have HCC-modifying functions. Thus, albumin has been shown to subdue HCC cell growth [33]; HCC-specific GGT isoforms are membrane glycoproteins that catalyze the first enzymatic step in the metabolism of glutathione and is important in maintaining intracellular cysteine and glutathione levels [34][35][36], ALKP might modulate cancer drug resistance [37] as might bilirubin [38,39]. Furthermore, platelet factors have HCC-stimulatory properties [24].…”

Section: Discussionmentioning

confidence: 99%

An HCC Aggressiveness Index and Blood GTP, Bilirubin and Platelet Levels

Carr¹,

Guerra²

2016

J Integr Oncol

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Four HCC characteristics typically inform tumor behavior: maximum tumor size, number of nodules, portal vein thrombosis and serum AFP level. The sum of these parameters was recently published as an HCC Aggressiveness Index. We aimed to validate this index retrospectively in a larger and independent HCC cohort of 2706 Italian HCC patients, and to evaluate a possible relationship between the index and liver function parameters. The scores in the HCC Aggressiveness Index were again found to significantly relate to patient survival. Furthermore, in a multiple logistic regression model of the Aggressiveness Index score categories, there were significant differences in several liver parameter terciles amongst the score categories, suggesting a relationship of liver function to tumor aggressiveness. It was concluded that a prognostically significant Tumor Aggressiveness Index was validated and was found to be related to levels of some common liver function parameters.

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“…Persistent inflammation in hepatitis activity and maintained necrosis-induced hepatocyte regeneration may lead to chromosomal damage and increased the risk for malignant transformation after hepatic resection (Poon et al 2000). In addition, HS-GGT (hepatoma specific GGT bands), a component of serum GGT by HCC tissue, is useful in diagnose of subclinical HCC (Xu et al 1992;Tsutsumi et al 1996;Wang et al 2009). The subclinical HCC cannot be easily discovered before and during operation, and it may reoccur after operation.…”

Section: Discussionmentioning

confidence: 99%

“…The subclinical HCC cannot be easily discovered before and during operation, and it may reoccur after operation. However, HS-GGT only accounts for 2.2% to 9.7% of total serum GGT, most of which is secreted by liver (Yao et al 2000;Wang et al 2009). Therefore, high GGT level might indicate increased inflammation, fibrosis and liver lobular structural disorder.…”

Section: Discussionmentioning

confidence: 99%

Postoperative Transarterial Chemoembolization Benefits Patients with High γ-Glutamyl Transferase Levels after Curative Hepatectomy for Hepatocellular Carcinoma: A Survival Stratification Analysis

Liu

Zhang

Qian

et al. 2012

Tohoku J. Exp. Med.

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Hepatocellular carcinoma (HCC) is the most common liver tumor in Asian countries, and hepatectomy is currently regarded as the optimal curative treatment for HCC; however, the postoperative outcome remains unsatisfactory. Aiming at further clarification of prognostic factors after hepatectomy, we adopted a detailed stratification on survival periods. A total of 428 HCC patients undergoing curative hepatectomy were firstly divided into two groups using 2-year survival as cutoff point. Multivariate analysis showed that tumor-related factors, including vascular invasion (P < 0.001), high Edmondson grade (P < 0.001), large tumor size (P < 0.001) and high serum alpha-fetoprotein level (P = 0.001), were significant determinants for early death within 2 years, while postoperative transarterial chemoembolization (TACE) was demonstrated a protective factor (P = 0.013). Then the 281 patients with survival > 2 years were divided into two subgroups according to survival or death during follow-up to examine the late death related factors. We found that high serum γ-glutamyl transpeptidase (GGT), indicating severity of underlying liver disease, was significantly linked to death in this stage (P = 0.006). In further comparison of survival rates between subgroups stratified by early-and late-death indictors, we found the long-term outcomes of patients with high serum GGT were poor, regardless of the factors related with primary tumor. Furthermore, postoperative TACE decreased late death rate of patients with high GGT levels. In conclusion, despite the overwhelmed effects of primary tumor in the early stage after hepatectomy, postoperative TACE is beneficial for HCC patients with poor liver status.

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Clinical application of an enzyme‐linked immunosorbent assay detecting hepatoma‐specific γ‐glutamyltransferase

Cited by 9 publications

References 32 publications

Platelet-Related Phenotypic Patterns in Hepatocellular Carcinoma Patients

Platelet-Related Phenotypic Patterns in Hepatocellular Carcinoma Patients

An HCC Aggressiveness Index and Blood GTP, Bilirubin and Platelet Levels

Postoperative Transarterial Chemoembolization Benefits Patients with High γ-Glutamyl Transferase Levels after Curative Hepatectomy for Hepatocellular Carcinoma: A Survival Stratification Analysis

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