2006
DOI: 10.1002/psc.726
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Clinical application of an enzyme immunoassay for cholecystokinin-like immunoreactive substance for determination of the human plasma levels: the effect of metoclopramide on gastrointestinal peptides and stress-related hormones

Abstract: Metoclopramide, a prokinetic drug, is widely used to treat vomiting and nausea. Delayed gastric emptying and continual stress are considered important factors, among others, that induce nausea and vomiting. One gastrointestinal motility regulatory factor has been assumed to be the induction of changes in the levels of peptides such as gastrin, somatostatin, motilin, and cholecystokinin (CCK) in plasma. In contrast, adrenocorticotropic hormone (ACTH) and cortisol are used as indicators of stress. Here, we studi… Show more

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Cited by 3 publications
(4 citation statements)
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“…The peptide hormone GAS is a member of the CCK family of peptides and stimulates gastric acid secretion (Rehfeld, 1981). Changes in gastrointestinal function have attracted attention, particularly the mechanisms responsible for alterations of gastrointestinal hormone induced by stress and depression (Itoh et al, 2005;Katagiri et al, 2006). Following the CUMS procedure, significant elevations in gastric mucosa CCK and serum GAS levels were observed in rats.…”
Section: Figmentioning
confidence: 98%
See 1 more Smart Citation
“…The peptide hormone GAS is a member of the CCK family of peptides and stimulates gastric acid secretion (Rehfeld, 1981). Changes in gastrointestinal function have attracted attention, particularly the mechanisms responsible for alterations of gastrointestinal hormone induced by stress and depression (Itoh et al, 2005;Katagiri et al, 2006). Following the CUMS procedure, significant elevations in gastric mucosa CCK and serum GAS levels were observed in rats.…”
Section: Figmentioning
confidence: 98%
“…On the other hand, dysregulation of the gastrointestinal function involved response to stress and depression (Fossey and Lydiard, 1990;Katagiri, et al, 2006;Koh and Park, 2008). The active factor gastrin (GAS) identified originally as a gastric blood-borne stimulant of acid secretion (Edkins, 1906), is a classical gut peptide hormone.…”
Section: Introductionmentioning
confidence: 98%
“…The study was carried out from 14: 00 to 18: 00. Blood sampling was performed to investigate circadian rhythms at 14: 00, 15: 30, and 18: 00 (three times) without administering a test medicine [9][10][11] .…”
Section: Methodsmentioning
confidence: 99%
“…Peptide levels in plasma were measured using highly sensitive enzyme immunoassays for gastrin- [9] , somatostatin- [10] , motilin- [12] , CCK- [11] , and ACTH-IS [13] , as previously described. Assays were performed using a delayed-addition method.…”
Section: Methodsmentioning
confidence: 99%