Clinical application of amplification-based versus amplification-free metagenomic next-generation sequencing test in infectious diseases
Zhe-Ying Wang,
Lu-Lu Li,
Xue-Lei Cao
et al.
Abstract:BackgroundRecently, metagenomic next-generation sequencing (mNGS) has been used in the diagnosis of infectious diseases (IDs) as an emerging and powerful tool. However, whether the complicated methodological variation in mNGS detections makes a difference in their clinical performance is still unknown. Here we conducted a method study on the clinical application of mNGS tests in the DNA detection of IDs.MethodsWe analyzed the effect of several potential factors in the whole process of mNGS for DNA detection on… Show more
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