Clinical application of accelerated rehabilitation surgery in elderly patients with colorectal cancer

Xu, Liping; Li, Xianrong; Song, Meixuan; Xu, Liang; Wu, Xunlian

doi:10.1097/md.0000000000022503

Cited by 3 publications

(3 citation statements)

References 12 publications

(11 reference statements)

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“…On postoperative days 1, 3, and 5, the patients in the ERAS group had significantly lower levels of inflammatory markers than those of the patients in the non-ERAS group, indicating that patients in the ERAS group were under a lower level of inflammatory stress, which is supported by Zhang's research. 27 HB level is an independent risk factor for the overall survival in patients with cancer 28 and can also reflect the nutritional status of patients. In our study, there were no significant differences in the HB levels between the two groups.…”

Section: Discussionmentioning

confidence: 99%

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Effects of the enhanced recovery after surgery (ERAS) protocol on the postoperative stress state and short‐term complications in elderly patients with colorectal cancer

Han,

Wan,

Chen

et al. 2024

Cancer Reports

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ObjectiveThe aim of this study was to evaluate the feasibility and necessity of enhanced recovery after surgery in elderly patients with colorectal cancer by observing inflammatory markers and postoperative complications.MethodsHospitalized colorectal cancer patients from the Affiliated Hospital of Jiangsu University from January 2021 to September 2022 were included in the study and divided into two groups: Enhanced Recovery After Surgery (ERAS) and non‐ERAS. Data on postoperative inflammatory markers and complications were also collected.ResultsA total of 313 patients with colorectal cancer were included: 182 in the ERAS group and 131 in the non‐ERAS group. The patients in the ERAS group had significantly shorter days of postoperative hospitalization, urinary catheter and drainage tube withdrawal times, and recovery of bowel function (P < .05) than those of the non‐ERAS group. Moreover, the ERAS group had lower hospitalization expenses than those of the non‐ERAS group (P < .05). However, the procalcitonin and tumor necrosis factor (TNF)‐α levels in the ERAS group was significantly lower than those in the non‐ERAS group on postoperative days 1 and 3 (P < .05), and the interleukin (IL)‐6 and IL‐10 levels in the ERAS group were significantly lower than those in the non‐ERAS group on the 1st, 3rd, and 5th postoperative days (P < .05). The C‐reactive protein (CRP) and white blood cell (WBC) levels in the ERAS group were lower than those in the non‐ERAS group on postoperative days 3 and 5 (P < .05). However, the hemoglobin levels did not differ significantly (P > .05). The albumin levels did not differ significantly between the two groups before surgery (P > .05); however, the albumin level in the ERAS group was higher than that in the non‐ERAS group on postoperative days 3 and 5 (P < .05). The ERAS patients had lower albumin levels after surgery than those of the non‐ERAS patients (P < .05).ConclusionERAS leads to a series of perioperative optimization measures, thereby reducing the postoperative stress response in elderly patients with colorectal cancer and the occurrence of perioperative complications.

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Section: Discussionmentioning

confidence: 99%

“…On postoperative days 1, 3, and 5, the patients in the ERAS group had significantly lower levels of inflammatory markers than those of the patients in the non‐ERAS group, indicating that patients in the ERAS group were under a lower level of inflammatory stress, which is supported by Zhang's research. 27 …”

Section: Discussionmentioning

confidence: 99%

Effects of the enhanced recovery after surgery (ERAS) protocol on the postoperative stress state and short‐term complications in elderly patients with colorectal cancer

Han,

Wan,

Chen

et al. 2024

Cancer Reports

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“…In an international comparison, Germany is one of the countries with a particularly high incidence, which was 57.0 in 2012 per 100,000 for men and 36.5 per 100,000 for women, with a mortality of 23.5 men per 100,000 and 14.4 per 100,000 women [ 54 ]. Especially older patients with colorectal cancer after surgical intervention experience, among other things, postoperative complications, major weight loss, extended hospital stays and a high recovery rate associated with high economic costs [ 55 ].…”

Section: Prehabilitation=get Fit For the Operation!mentioning

confidence: 99%

Prehabilitation in elective surgical interventions – what must the general and abdominal surgeon know

Meißner,

Meyer,

Ridwelski

2023

Innovative Surgical Sciences

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Objectives For years, many efforts have been invested to prepare patients, in particular, those with reduced physical and psychic status, much better to provide and finally achieve better outocme if there is time available to provide several beneficial measures. Methods Therefore, the objective was to illustrate the concept and various single elements of a complex prehabilitation concept based on (i) selective references from the medical literature and (ii) own clinical experiences from clinical practice in general and abdominal surgery. Results Prehabiliation can be considered the solution of the efforts to improve preoperative status for patients in a disadvantageous status for almost all types of surgery and all other operative and/or interventional procedures. It is the targeted process to improve individual functionality and organ function before a planned (elective) surgical intervention; P. comprises basically nutritional, physical and psychological measures; P. focusses especially onto the elderly, frail and malnourished patients before a planned surgical intervention; the overall aim is to significantly improve final outcome characterized by shorter length of stay, lower complication rate and mortality as well as cost efficiency; P. is especially important in cancer surgery, in which the beneficial effects can be particularly implemented; P. programs and/or “Standard Operating Protocols“ (SOP) may help to establish and materialize its single aspects and enhanced recovery after surgery (ERAS). There is still further potential to reliably establish and to utilize the options of prehabilitation measures as listed above. Conclusions Prehabiliation is an indispensable aspect in today’s preparation for elective surgery, which needs to become obligatory part of the preparation measures to planned surgical interventions, which can further contribute to a better final outcome and ERAS as well as, in addtion, needs to be further developed and accomplished.

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Application of Different Ventilation Modes Combined with AutoFlow Technology in Thoracic Surgery

Wang

Yang

Chengzong

et al. 2022

Journal of Healthcare Engineering

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To investigate the effect of AutoFlow on airway pressure and hemodynamics in mechanical ventilation constant volume-control ventilation mode, 100 patients receiving mechanical ventilation were randomly divided into observation group (SIMV-PSV-PEEP + AutoFlow) and control group (SIMV-PSV-PEEP). The results showed that the peak airway pressure and average airway pressure decreased with different flow rate settings and automatic flow conversion ( P < 0.05 ). The peak airway pressure and mean airway pressure decreased with different resistance settings ( P < 0.05 ). With different compliance settings, the peak airway pressure and average airway pressure decreased after being assisted with an automatic converter ( P < 0.05 ). Adding AutoFlow on the basis of SIMV-PSV mode can significantly reduce peak inspiratory pressure (PIP), mean airway pressure (Pmean), and airway resistance (R). There was no significant difference in hemodynamic monitoring results between the observation group and the control group. It is proved that the SIMV constant volume-controlled ventilation mode combined with AutoFlow can not only ensure tidal volume but also avoid excessive airway pressure, which has little effect on hemodynamics.

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Clinical application of accelerated rehabilitation surgery in elderly patients with colorectal cancer

Cited by 3 publications

References 12 publications

Effects of the enhanced recovery after surgery (ERAS) protocol on the postoperative stress state and short‐term complications in elderly patients with colorectal cancer

Effects of the enhanced recovery after surgery (ERAS) protocol on the postoperative stress state and short‐term complications in elderly patients with colorectal cancer

Prehabilitation in elective surgical interventions – what must the general and abdominal surgeon know

Application of Different Ventilation Modes Combined with AutoFlow Technology in Thoracic Surgery

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