Clinical Application of 18F-FDG-PET Quantification in Hematological Malignancies: Emphasizing Multiple Myeloma, Lymphoma and Chronic Lymphocytic Leukemia

Zadeh, Mahdi Zirakchian

doi:10.1016/j.clml.2023.07.008

Cited by 2 publications

(2 citation statements)

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“…These comments further elaborate on the topics the authors are working on together and the potential for collaboration on these topics. (19) and Zadeh (20) show that PET scans have high efficacy in the diagnosis of specific cancer types, especially prostate cancer and bone metastases. In terms of Patient Management and Follow-up, the management and follow-up of metastases is important for patient prognosis and quality of life.…”

Section: Co-author Analysismentioning

confidence: 99%

“…Furthermore, the effectiveness of imaging techniques is high for specific cancer types such as prostate cancer and bone metastases (15)(16)(17). Comparison of the diagnostic performance of different imaging techniques is also frequently discussed in the literature (18)(19)(20). Furthermore, advanced technologies like radiomics and automation have demonstrated their effectiveness in cancer diagnosis (21,22).…”

Section: Introductionmentioning

confidence: 99%

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Assessing Metastasis through Positron Emission Tomography (PET): An In-depth Analysis and Mapping of Thematic Clusters and Prevailing Topics in Nuclear Medicine Research

Afşin

2023

Med Sci Discov

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Objective: The primary objective of the study is to conduct a critical evaluation of thematic categories within the field of nuclear medicine literature, specifically focusing on positron emission tomography (PET) imaging techniques and the detection and evaluation of metastasis, through the application of bibliometric analysis methods. Method: Co-citation, co-occurrence and co-authorship analyses were performed on 588 academic publications selected using the Web of Science database. The analyses were performed using R-based Bibliometrix software, Python and Microsoft Excel. Results: The findings derived from the co-citation and co-occurrence network analyses shed light on the intricate nature of thematic categories within the nuclear medicine literature and provide insights into the core topics. Topics such as metastasis and tumor staging, optimisation of imaging methodology, and standardisation of clinical practice are prominent topics in the study. In particular, a single-authored article has been observed to make a significant contribution to knowledge on the efficacy of different radioactive markers used in the diagnosis of neuroendocrine tumors. Conclusion: This bibliometric assessment addresses the multidisciplinary and thematic dimensions of an in-depth understanding of the field of nuclear medicine. The study effectively identified four main thematic clusters 'PET and Cancer Types', 'FDG-PET ', 'Prostate Cancer and Recurrence', and 'Cancer Management and Imaging' and highlights the interrelatedness and importance of these categories.

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Section: Co-author Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessing Metastasis through Positron Emission Tomography (PET): An In-depth Analysis and Mapping of Thematic Clusters and Prevailing Topics in Nuclear Medicine Research

Afşin

2023

Med Sci Discov

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Significance of PET/CT Imaging in Myeloma Assessment: Exploring Novel Applications beyond Osteolytic Lesion Detection and Treatment Response

Zirakchian Zadeh

2024

Onco

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In multiple myeloma (MM), specific cytokines produced by plasma cells disrupt the equilibrium between osteoblasts and osteoclasts. As a result, MM patients experience an increase in osteoclast activity and a decrease in osteoblast activity. This disparity is fundamental to the development of myeloma bone disease. Lytic lesions, which are a feature of MM, can result in pathologic fractures and excruciating pain. For many years, whole-body X-ray radiography has been the standard imaging method for identifying lytic lesions. However, its sensitivity is limited because it can only detect lesions once the bone mass has been reduced by 30% to 50%. Hence, utilizing advanced and sensitive imaging modalities, such as positron emission tomography (PET) fused with computed tomography (CT), is crucial for the early detection of osteolytic lesions. Among radiotracers used in PET imaging, 1⁸F-fluorodeoxyglucose ([18F]FDG) is the most commonly employed in the field of oncology. Currently, most guidelines include [18F]FDG PET/CT in the assessment of myeloma patients, particularly for detecting osteolytic lesions, evaluating treatment response, and assessing extramedullary and residual disease. Nonetheless, in recent years, new applications of PET/CT for evaluating myeloma have been investigated. These include assessing aspects such as bone turnover, dual-time-point imaging (early and delayed scans), the impact of chemotherapy on the brain (commonly known as ‘chemo brain’), innovative PET radiotracers, and the use of artificial intelligence technology. This article aims to provide a comprehensive review of both conventional and innovative uses of PET/CT in evaluating multiple myeloma.

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Clinical Application of 18F-FDG-PET Quantification in Hematological Malignancies: Emphasizing Multiple Myeloma, Lymphoma and Chronic Lymphocytic Leukemia

Cited by 2 publications

References 82 publications

Assessing Metastasis through Positron Emission Tomography (PET): An In-depth Analysis and Mapping of Thematic Clusters and Prevailing Topics in Nuclear Medicine Research

Assessing Metastasis through Positron Emission Tomography (PET): An In-depth Analysis and Mapping of Thematic Clusters and Prevailing Topics in Nuclear Medicine Research

Significance of PET/CT Imaging in Myeloma Assessment: Exploring Novel Applications beyond Osteolytic Lesion Detection and Treatment Response

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