Clinical application of 11-deoxycortisol in visualizing prolapsed vitreous body after posterior capsule rupture in cataract surgery

Kaji, Yuichi; Hiraoka, Takahiro; Okamoto, Fumiki; Sato, Masaki; Oshika, Tetsuro

doi:10.1016/j.jcrs.2004.10.059

Cited by 8 publications

(8 citation statements)

References 17 publications

(12 reference statements)

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“…To avoid its potential toxicities, it is preferable to use preservative-free TA. In most cases; decantation of preservative prior to injection is supposed to [114,115]. 11-deoxycortisol is a precursor of cortisol in the cascade of steroid hormone metabolism.…”

Section: Adverse Eventsmentioning

confidence: 99%

Visualizing vitreous in vitrectomy by triamcinolone

Sakamoto

Ishibashi

2009

Graefes Arch Clin Exp Ophthalmol

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Section: Adverse Eventsmentioning

confidence: 99%

Visualizing vitreous in vitrectomy by triamcinolone

Sakamoto

Ishibashi

2009

Graefes Arch Clin Exp Ophthalmol

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“…Therefore, 11-DC left in the anterior chamber is easily cleared and excreted through the urine. In their study, there were white particles on the surface of the iris or in the vitreous body on the day following surgery, but all the particles had completely disappeared within 2 days after surgery [27]. This hydrophilic characteristic of 11-DC is highly advantageous over hydrophobic cholesterol as a tool to visualize the vitreous body.…”

Section: Triamcinolone Acetonide and Other Related Materialsmentioning

confidence: 97%

“…A novel approach related to use of TA will be described. Kaji et al reported a new technique for visualising the vitreous in the anterior chamber using 11-deoxycortisol (11-DC) [27]. Its suspension can be prepared without the antiseptic and emulsifying agents contained in commercially available TA.…”

Section: Triamcinolone Acetonide and Other Related Materialsmentioning

confidence: 99%

Chromovitrectomy in Vitreous Loss During Cataract Surgery

Sakamoto¹,

Hisatomi²

2013

Cataract Surgery

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“…It was recently reported that 11‐deoxycortisol, a precursor of cortisol in the cascade of steroid metabolism, can be used to visualize the vitreous body (Kaji et al. 2004, 2005).…”

Section: Introductionmentioning

confidence: 99%

Comparison of triamcinolone acetonide, 11‐deoxycortisol and other lipid formulae for the visualization of vitreous body in the anterior chamber after posterior capsule rupture in animal models

Kaji

Hiraoka

Okamoto

et al. 2008

Acta Ophthalmologica

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ABSTRACT.Purpose: The efficacy and toxicity of triamcinolone acetonide and other lipid formulae -calcium palmitate, cholesterol and 11-deoxycortisol -in the visualization of the prolapsed vitreous body in the anterior chamber after posterior capsule rupture were investigated in animal models. Methods:In porcine eyes, a suspension of calcium palmitate, cholesterol, triamcinolone acetonide and 11-deoxycortisol was injected into the anterior chamber after intentionally creating posterior capsule rupture. Following gentle irrigation and aspiration, the vitreous body prolapsed in the anterior chamber was removed using an anterior vitrectomy cutter. In phakic rabbit eyes, the side-effects of the reagents were assessed for biomicroscopic appearance, intraocular pressure (IOP) and corneal histology.Results: The suspension of calcium palmitate, cholesterol, triamcinolone acetonide and 11-deoxycortisol was effective in the visualization of the vitreous body prolapsed in the anterior chamber after posterior capsule rupture. When cholesterol and calcium palmitate were injected into the anterior chamber, they remained there; this induced a significant increase in IOP and corneal oedema. In contrast, most of the triamcinolone acetonide and 11-deoxycortisol that was injected into the anterior chamber had disappeared a day after the injection without affecting IOP or corneal endothelial density. When injected into the intravitreous cavity, triamcinolone led to a significant increase in IOP 2 and 4 weeks after the injection. However, calcium palmitate, cholesterol and 11-deoxycortisol injected into the vitreous cavity had no effect on IOP at 4 weeks. Conclusion:The suspension of triamcinolone acetonide and 11-deoxycortisol was effective in visualizing the vitreous body prolapsed in the anterior chamber after posterior capsule rupture. However, the amount of the reagent must be kept to a minimum to prevent the potential risk of ocular toxicities and postoperative late-onset ocular hypertension.

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Clinical application of 11-deoxycortisol in visualizing prolapsed vitreous body after posterior capsule rupture in cataract surgery

Abstract: Injection of 11-deoxycortisol helped visualize the vitreous body in the anterior chamber after posterior capsule rupture. The technique minimized intraoperative and postoperative complications related to posterior capsule rupture and vitreous loss during cataract surgery [corrected]

Cited by 8 publications

References 17 publications

Visualizing vitreous in vitrectomy by triamcinolone

Visualizing vitreous in vitrectomy by triamcinolone

Chromovitrectomy in Vitreous Loss During Cataract Surgery

Comparison of triamcinolone acetonide, 11‐deoxycortisol and other lipid formulae for the visualization of vitreous body in the anterior chamber after posterior capsule rupture in animal models

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