Clinical application and detection techniques of liquid biopsy in gastric cancer

Ma, Shuo; Zhou, Meiling; Xu, Yanhua; Gu, Xinliang; Zou, Mingyuan; Abudushalamu, Gulinaizhaer; Yao, Yuming; Fan, Xuetong; Wu, Guoqiu

doi:10.1186/s12943-023-01715-z

Cited by 57 publications

(42 citation statements)

References 230 publications

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“…Second, only a small number of circRNAs have been tested in conjunction with traditional tumor markers. As more and more differentially expressed circRNAs in GC are explored, this provides us with a good environment 30 . Whether utilizing technology to jointly diagnose the majority of circRNAs or other markers can maximize the diagnostic effect remains to be seen.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive evaluation of serum circHAS2 as a novel diagnostic and prognostic biomarker for gastric cancer

Ma,

Yao,

et al. 2023

Molecular Carcinogenesis

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The diagnosis and screening indicators for gastric cancer (GC) are not satisfactory, resulting in a large number of GC patients being missed and missing the best treatment time. Due to the special structure of circular RNAs (circRNAs), they have a more accurate and powerful ability to detect tumor occurrence. In addition, circHAS2 has been found to promote the proliferation, migration, and invasion of GC cells. Therefore, this study explored the potential of circHAS2 as a biomarker for GC. The expression level of circHAS2 in the specimens was detected by real‐time fluorescent quantitative PCR. The molecular characteristics of circHAS2 were verified by agarose gel electrophoresis and Sanger sequencing. The feasibility of the circHAS2 detection method was verified by room temperature placement and repeated freezing and thawing. The diagnostic effect of circHAS2 on GC was evaluated by receiver‐operating curve analysis. The correlation between circHAS2 expression level and clinical pathological parameters was analyzed using the χ2‐test. Kaplan–Meier survival curve analysis was used to analyze the survival situation of the circHAS2 high‐ and low‐expression group. Univariate and multivariate Cox regression analysis was used to evaluate the influencing factors of prognosis in GC patients. CircHAS2 in cells can be secreted into the blood, and its expression level is significantly upregulated in the serum of patients with GC. The expression level of circHAS2 is correlated with the tissue differentiation, tumor node metastasis staging, classification, and lymph node metastasis of GC patients. CircHAS2 can effectively identify GC and even early GC. In addition, the expression levels of circHAS2 in postoperative GC patients significantly decreased and returned to normal after the second stage of chemotherapy. Finally, the circHAS2 low‐expression group had better survival. The upregulated expression of circHAS2 in the serum of GC patients can effectively identify GC and early GC and can be used for effective monitoring of the prognosis of GC patients. In summary, circHAS2 can be used as an effective diagnostic and prognostic marker for GC.

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Section: Discussionmentioning

confidence: 99%

Comprehensive evaluation of serum circHAS2 as a novel diagnostic and prognostic biomarker for gastric cancer

Ma,

Yao,

et al. 2023

Molecular Carcinogenesis

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“…Research shows that GC with high PD-L1 expression, EBV+, and TMB-high responds better to immunotherapy, while H. pylori infection may impair its efficacy ( Lin et al, 2020 ; Oster et al, 2022 ). Circulating tumor DNA, monitored by liquid biopsies, shows potential in predicting ICI responses ( Jin et al, 2020 ; Ma et al, 2023 ). These biomarkers are worth further investigation and combinatorial biomarker strategies are more reasonable than traditional single immune-specific markers.…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

Application of immune checkpoint inhibitors for resectable gastric/gastroesophageal cancer

Lin,

Chen,

Huang

et al. 2024

Front. Pharmacol.

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Gastric/gastroesophageal junction (G/GEJ) cancer represents a significant global health challenge. Radical surgery remains the cornerstone of treatment for resectable G/GEJ cancer. Supported by robust evidence from multiple clinical studies, therapeutic approaches, including adjuvant chemotherapy or chemoradiation, and perioperative chemotherapy, are generally recommended to reduce the risk of recurrence and enhance long-term survival outcomes post-surgery. In recent years, immune checkpoint inhibitors (ICIs) have altered the landscape of systemic treatment for advanced or metastatic G/GEJ cancer, becoming the standard first-line therapy for specific patients. Consequently, exploring the efficacy of ICIs in the adjuvant or neoadjuvant setting for resectable G/GEJ cancer is worthwhile. This review summarizes the current advances in the application of ICIs for resectable G/GEJ cancer.

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“…Exosomes are widely recognized as significant biomarkers for cancer diagnosis, prediction, and monitoring ( 78 ). Due to their stability and prevalence in circulation, they serve as valuable indicators for liquid biopsy techniques ( 79 ), enabling more accurate and less invasive treatments ( 80 ). Considering the active cross-talk of exosomes between immune and cancer cells, they can be utilized for immunotherapy to promote ( 81 , 82 ) or suppress ( 83 , 84 ) tumor proliferation.…”

Section: Exosomes and Tumor Microenvironmentmentioning

confidence: 99%

Revolutionizing anti-tumor therapy: unleashing the potential of B cell-derived exosomes

et al. 2023

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B cells occupy a vital role in the functioning of the immune system, working in tandem with T cells to either suppress or promote tumor growth within the tumor microenvironment(TME). In addition to direct cell-to-cell communication, B cells and other cells release exosomes, small membrane vesicles ranging in size from 30-150 nm, that facilitate intercellular signaling. Exosome research is an important development in cancer research, as they have been shown to carry various molecules such as major histocompatibility complex(MHC) molecules and integrins, which regulate the TME. Given the close association between TME and cancer development, targeting substances within the TME has emerged as a promising strategy for cancer therapy. This review aims to present a comprehensive overview of the contributions made by B cells and exosomes to the tumor microenvironment (TME). Additionally, we delve into the potential role of B cell-derived exosomes in the progression of cancer.

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Clinical application and detection techniques of liquid biopsy in gastric cancer

Cited by 57 publications

References 230 publications

Comprehensive evaluation of serum circHAS2 as a novel diagnostic and prognostic biomarker for gastric cancer

Comprehensive evaluation of serum circHAS2 as a novel diagnostic and prognostic biomarker for gastric cancer

Application of immune checkpoint inhibitors for resectable gastric/gastroesophageal cancer

Revolutionizing anti-tumor therapy: unleashing the potential of B cell-derived exosomes

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