Clinical and virological profiling of sporadic hepatitis E virus infection in China

Wang, Lin; Liu, Lin; Wei, Yongli; Wang, Qianhui; Tian, Qing; Zhang, Hui

doi:10.1016/j.jinf.2016.06.005

Cited by 31 publications

(28 citation statements)

References 27 publications

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“…In China, genotype 4 HEV (HEV‐4) widely circulates in pigs and has replaced genotype 1 as the most common cause of acute hepatitis E . However, little is known about the characteristics of HEV‐4 infection in immunocompromised patients.…”

Section: Introductionmentioning

confidence: 99%

Genotype 4 hepatitis E virus is a cause of chronic hepatitis in renal transplant recipients in Hong Kong

Sridhar

Chan

Yap

et al. 2017

Journal of Viral Hepatitis

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Section: Introductionmentioning

confidence: 99%

Genotype 4 hepatitis E virus is a cause of chronic hepatitis in renal transplant recipients in Hong Kong

Sridhar

Chan

Yap

et al. 2017

Journal of Viral Hepatitis

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“…HEV-3 and HEV-4 circulate in swine populations (including pigs and wild boar) and are an important cause of zoonotic foodborne autochthonous human hepatitis E in areas with high socioeconomic development [38]. HEV-3 is enzootic in the Americas, Europe and parts of Asia while HEV-4 is enzootic in China and Korea and is emerging as the major cause of human hepatitis E in the region, outcompeting HEV1 in the last decade [39,40,41]. HEV-5 and HEV-6 are novel genotypes identified in Japanese wild boars [42,43] and cluster together with HEV-4 isolates on phylogenetic analysis (Figure 2).…”

Section: Beyond the Species Level: Hev Genotypes And Subgenotypesmentioning

confidence: 99%

Hepatitis E Virus Genotypes and Evolution: Emergence of Camel Hepatitis E Variants

Sridhar

Teng

Chiu

et al. 2017

IJMS

192

160

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Hepatitis E virus (HEV) is a major cause of viral hepatitis globally. Zoonotic HEV is an important cause of chronic hepatitis in immunocompromised patients. The rapid identification of novel HEV variants and accumulating sequence information has prompted significant changes in taxonomy of the family Hepeviridae. This family includes two genera: Orthohepevirus, which infects terrestrial vertebrates, and Piscihepevirus, which infects fish. Within Orthohepevirus, there are four species, A–D, with widely differing host range. Orthohepevirus A contains the HEV variants infecting humans and its significance continues to expand with new clinical information. We now recognize eight genotypes within Orthohepevirus A: HEV1 and HEV2, restricted to humans; HEV3, which circulates among humans, swine, rabbits, deer and mongooses; HEV4, which circulates between humans and swine; HEV5 and HEV6, which are found in wild boars; and HEV7 and HEV8, which were recently identified in dromedary and Bactrian camels, respectively. HEV7 is an example of a novel genotype that was found to have significance to human health shortly after discovery. In this review, we summarize recent developments in HEV molecular taxonomy, epidemiology and evolution and describe the discovery of novel camel HEV genotypes as an illustrative example of the changes in this field.

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“…However, investigations conducted separately in several areas in China where rabbit HEV and HEV‐4 were highly prevalent in farmed rabbits and pigs respectively, could not observe cross‐species infection of HEV strains between rabbits and swine (Geng et al., ; Han et al., ). In these regions, all of the HEV strains detected from hepatitis E patients belong to HEV‐4 of which the nucleotide sequence was highly similar to swine‐derived HEV‐4 sequences indicating the transmission risks of pigs, but not rabbits (Geng et al., ; Han et al., ; Wang, Liu, et al., ). To date, only a few strains detected from patients with HEV infection in France have been identified to have similar sequences with the rabbit HEV (Abravanel et al., ; Izopet et al., ).…”

Section: Introductionmentioning

confidence: 99%

High seroprevalence of hepatitis E virus in rabbit slaughterhouse workers

Yang

Zhao

Geng³

et al. 2019

Transbound Emerg Dis

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Hepatitis E virus (HEV) was first detected in rabbits in the year 2009. Rabbit HEV is now known to be widely prevalent in rabbits and tentatively assigned into genotype 3 (HEV‐3) as subgenotype‐3ra (HEV‐3ra). However, its role in human infection remains undetermined. This study was conducted to investigate the prevalence of HEV infection among rabbit slaughterhouse workers and to identify whether the workers exposed to rabbits are at a higher risk of HEV infection. Seventy‐five workers at rabbit slaughterhouses and a control group of 421 general adults in the same area in Hebei province, China, were serologically examined for anti‐HEV antibodies. HEV seroprevalences between the slaughterhouse workers and the general adults were compared. Age‐adjusted prevalence of anti‐HEV immunoglobulin G (IgG) in the rabbit slaughterhouse workers and control group was 46.1% and 10.8% respectively. The slaughterhouse workers had significantly higher seroprevalence and an approximately 6.9‐fold increased risk for being seropositive for anti‐HEV IgG as compared to the general population (odds ratio, 6.9; 95% CI: 4.3, 10.9). In slaughterhouse workers, anti‐HEV IgG positive rate was positively associated with working years; in general adults, this rate was positively associated with age. The prevalence of anti‐HEV immunoglobulin M (IgM) among exposed workers (6.7%) was significantly higher than that of control groups (1.2%). In conclusion, the seroprevalence of HEV is significantly higher in slaughterhouse workers than in general adults indicating that occupational exposure to rabbits is a potential risk factor for HEV infection.

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Clinical and virological profiling of sporadic hepatitis E virus infection in China

Abstract: All HEV isolates belonged to HEV-4 and showed high sequence similarity to swine HEV-4. Most of the sporadic cases had typical clinical symptoms, signs of AHE, and elevated levels of serum bilirubin and liver enzymes.

Cited by 31 publications

References 27 publications

Genotype 4 hepatitis E virus is a cause of chronic hepatitis in renal transplant recipients in Hong Kong

Genotype 4 hepatitis E virus is a cause of chronic hepatitis in renal transplant recipients in Hong Kong

Hepatitis E Virus Genotypes and Evolution: Emergence of Camel Hepatitis E Variants

High seroprevalence of hepatitis E virus in rabbit slaughterhouse workers

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