Clinical and virological findings in mixed cryoglobulinaemia

Mazzaro, Cesare; Tulissi, P.; Moretti, Michèle; Mazzoran, L.; Pussini, Elisabetta; Crovatto, M; Santini, Gianfranco; Pozzato, Gabriele

doi:10.1111/j.1365-2796.1995.tb00913.x

Cited by 29 publications

(13 citation statements)

References 21 publications

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“…But as these data were established with a rather small group of 11 SMC patients, these statistical findings have to be confirmed on larger series or meta-analysis studies since SMC is rare. Nevertheless these results are in accord with other studies [Willems et al, 1994;Galli et al, 1995;Mazzaro et al, 1995;Sinico et al, 1995;Silvestri et al, 1996;Zignego et al, 1996], showing that HCV 1 and 2 seemed to be the only genotypes associated with SMC. The hypothesis that HCV genotypes implicated in SMC might be poor-interferon-responder genotypes is supported by our data, since genotype 1b infections are considered to be more resistant to interferon [Yoshioka et al, 1992;Nousbaum et al, 1995] and are predominant in the SMC group (63.6% vs. 47%, NS).…”

Section: Association Of Chronic Hcv Infection and Mixed Cryoglobulinemiasupporting

confidence: 95%

“…genotypes distribution between groups, two comparisons were done: 1) each HCV genotype was individually tested, 2) genotypes 1 and 2 were grouped in one class and other genotypes (3 to 5) in the other, since preliminary studies showed that patients with MC syndromes seem to be infected with HCV genotypes 1 and 2 [Galli et al, 1995;Mazzaro et al, 1995;Silvestri et al, 1996;Sinico et al, 1995;Willems et al, 1994;Zignego et al, 1996].…”

Section: Statistical Analysesmentioning

confidence: 99%

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Hepatitis C virus genotypes implicated in mixed cryoglobulinemia

et al. 1998

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Recent reports suggest that hepatitis C virus (HCV) might be a causative agent of mixed cryoglobulinemia. To determine whether the HCV genotype is a factor implicated in the onset of cryoglobulinemia, genotyping by direct sequencing of polymerase chain reaction products of the 5' non coding region was carried out among 45 HCV-infected patients. Genotypes 1 and 2 were found more prevalent in symptomatic cryoglobulinemia patients. Due to the presence of genotypes 4 and 5 found in this panel of French patients (9.3%), HCV genotyping based on sequence determination is recommended.

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Section: Association Of Chronic Hcv Infection and Mixed Cryoglobulinemiasupporting

confidence: 95%

Section: Statistical Analysesmentioning

confidence: 99%

Hepatitis C virus genotypes implicated in mixed cryoglobulinemia

et al. 1998

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“…Renal manifestations are reported in 20 to 35% of MC patients [14,25,26]. The most frequent clinical and histological picture is that of acute or chronic type-I membranoproliferative glomerulonephritis with sub-endothelial deposits [27].…”

Section: Renal Involvementmentioning

confidence: 99%

Hepatitis C Virus Infection Induced Vasculitis

Cacoub

Saadoun

2008

Clinic Rev Allerg Immunol

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Cryoglobulinemia are immune complexes that may induce systemic cryoglobulinemic vasculitis, a small-vessel vasculitis involving the skin, the joints, the peripheral nerve system, and the kidneys. During the last 15 years, progresses have been done after the discovery of the hepatitis C virus, the main cause of cryoglobulins. Main factors associated with cryoglobulin production are female gender, alcohol intake above 50 g/day, extensive liver fibrosis, and steatosis. Symptomatic cryoglobulins (i.e., vasculitis) are associated with older age, longer duration of infection, and main characteristics of cryoglobulin (type II, IgM kappa, high serum levels). The physiopathology is complex, and it involves humoral immunity, B- and T-cellular immunity but not the virus itself. Peg-Interféron alpha Ribavirine combination leads to a virological and clinical response of the vasculitis in about 70% of patients. In nonresponders, recent open series suggested the efficacy of Rituximab with a good response in up to 80% of patients but a relapse in 42% after 7 months after the last infusion. For future prospects and projects, new therapeutic strategies include a combination of best antiviral treatment with Peg-Interferon plus Ribavirin and Rituximab. Multicenter controlled trials are mandatory.

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“…El virus de la hepatitis C es el más frecuentemente asociado a crioglobulinemia mixta esencial (CME), con prevalencias de ARN viral en suero que varían, de acuerdo a los estudios, entre 81% y 91%, de anticuerpos Ab-HCV en suero entre 30% y 98% y en crioprecipitado entre 11% y 94% (7,19,20,21). Existe a hipótesis de que la infección por el VHC es el factor precipitante de la proliferación de linfocitos B mecanismo presente en CM.…”

Section: Discusionunclassified

Crioglobulinemia mixta asociada a infección por hepatitis C y gangrena de miembros inferiores.

Rio

Raez

2013

Rev Med Hered

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SUMMARYCryoglobulinemia is a systemic disorder in which the blood contains inmunoglobulins that reversibly precipitate in the cold, giving rise to immune complex deposition that may cause small vessel vasculitis. A strong association with Hepatitis C has been made in the latest years. We describe a patient with hepatitis C and Cryoglobulinemia who wazzu developed one of the most severe crises with clinical manifestations of gangrene in feet and upper extremities. Patient ended with amputation of the lower limbs. His life was saved with plasmapheresis, use of frozen plasma, steroids, heparin and alfa interferon. In this article we report the case and we do a review of the literature on cryoglobulinemia. (Rev Med Hered 1997;8:183-188).

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Clinical and virological findings in mixed cryoglobulinaemia

Cited by 29 publications

References 21 publications

Hepatitis C virus genotypes implicated in mixed cryoglobulinemia

Hepatitis C virus genotypes implicated in mixed cryoglobulinemia

Hepatitis C Virus Infection Induced Vasculitis

Crioglobulinemia mixta asociada a infección por hepatitis C y gangrena de miembros inferiores.

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