2021
DOI: 10.1007/s15010-021-01594-w
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Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic: a prospective observational study

Abstract: Purpose Adequate patient allocation is pivotal for optimal resource management in strained healthcare systems, and requires detailed knowledge of clinical and virological disease trajectories. The purpose of this work was to identify risk factors associated with need for invasive mechanical ventilation (IMV), to analyse viral kinetics in patients with and without IMV and to provide a comprehensive description of clinical course. Methods A cohort of 168 hos… Show more

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Cited by 28 publications
(19 citation statements)
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References 37 publications
(33 reference statements)
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“…All patients were confirmed by RT-qPCR for COVID-19; serum or plasma were collected between 30 and 40 days post symptom onsets. Further sera were available through a prospective observational cohort study conducted at Charité- Universitätsmedizin Berlin 30 , a prospective observational cohort study on immunogenicity and reactogenicity of COVID-19 vaccines in healthcare workers 31 , and from patients who recovered from mild to moderate COVID-19 for convalescent plasma donation. (https://www.frontiersin.org/articles/10.3389/fimmu.2020.628971/full).…”
Section: Methodsmentioning
confidence: 99%
“…All patients were confirmed by RT-qPCR for COVID-19; serum or plasma were collected between 30 and 40 days post symptom onsets. Further sera were available through a prospective observational cohort study conducted at Charité- Universitätsmedizin Berlin 30 , a prospective observational cohort study on immunogenicity and reactogenicity of COVID-19 vaccines in healthcare workers 31 , and from patients who recovered from mild to moderate COVID-19 for convalescent plasma donation. (https://www.frontiersin.org/articles/10.3389/fimmu.2020.628971/full).…”
Section: Methodsmentioning
confidence: 99%
“…The exploratory cohort used for marker identification and model generation consisted of the 50 most severely ill COVID-19 patients out of a cohort of 168 patients with varying disease severity, treated between 15 March and 16 September 2020 at Charité University Hospital, Berlin, Germany (Fig. 1A) [13,18,28]. All 50 patients required intensive care with invasive mechanical ventilation plus additional organ support such as renal replacement therapy (RRT), ECMO, or vasopressors, corresponding to grade 7 on the WHO Ordinal Scale for Clinical Improvement.…”
Section: Resultsmentioning
confidence: 99%
“…Patients included in this analysis are a sub-cohort of the Pa-COVID-19 study conducted at Charité -Universitätsmedizin Berlin, a prospective observational cohort study on the pathophysiology of COVID-19 as described previously [18,28]. All patients with PCR-confirmed SARS-CoV-2 infection that progressed to critical disease (WHO grade 7, i.e.…”
Section: Charité Patient Cohort and Clinical Datamentioning
confidence: 99%
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