Clinical and urodynamic impact of detrusor overactivity in women with overactive bladder

Jiménez-Cidre, Miguel Ángel; López-Fando, Luis; Mora, A.M.; Urology, Urodynamic

doi:10.1016/j.acuroe.2018.07.010

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Various studies by different authors have confirmed the utility of Qmax and voiding time in OAB. [6][7][8] Overactive bladder syndrome score (OABS) has also been used to diagnose and quantify OAB and is a simple tool taking frequency of urine in day and night, urgency (sudden desire to pass urine and is difficult to defer) and urge incontinence into consideration. Various authors have used OABS for quantification of OAB and to see efficacy of drugs like solifenacin on OAB.…”

Section: Discussionmentioning

confidence: 99%

“…In fact in diagnosis and quantification of OAB, to find whether detrusor overactivity is present or not, to calculate total urine voided at each micturition (Vmax) and total voiding time. [6][7][8] Urodynamic studies are also used for prognostication of various treatment outcomes including Mirabegron therapy. 8 Yoo et al from South Korea studied prevalence of various lower urinary tract symptoms including OAB in population aged 40 years or over.…”

Section: Introductionmentioning

confidence: 99%

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Correlation of incontinence impact questionnaire score in overactive bladder syndrome cases with urodynamic findings

Sharma

Chauhan

Bhatla

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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Background: Overactive bladder syndrome (OAB) is a common condition. The aim of the present study was to correlate the incontinence impact questionnaire (IIQ) score with urodynamic studies in patients of overactive bladder syndrome.Methods: It was a prospective study performed in a tertiary referral centre on 60 women with symptomatology of OAB. IIQ score was calculated and urodynamic studies were performed in all patients in which detrusor overactivity, maximum flow rate of urine per second (Qmax) and voiding time in seconds was calculated in all women.Results: The mean age was 42.3±9.91 years, mean body mass index was 24.7±2.71 kg/m2, mean parity was 2.4 and mean serum creatinine level was 0.84±0.21 mg/dl. Symptoms seen were urgency (100%), frequency (100%), urge incontinence (95.0%) and nocturia (76.6%). IIQ score ranged from 7-20 with mean being 12.27±3.38. OAB was mild in 36.6%, moderate in 41.66% and severe in 21.66% patients. On urodynamic studies, detrusor overactivity was present in 75% cases being 59% in mild, 80% in moderate and 76.92% in severe OAB. Mean Qmax increased with severity of OAB and was 29.55ml/second in mild OAB, 30.36ml/second in moderate OAB and 31.59 ml/second in severe OAB. Mean voiding time decreased with severity of OAB and was 33.44 seconds in mild OAB, 32.14 seconds in moderate OAB and 31.47 seconds in severe OAB.Conclusions: IIQ score and urodynamic studies are useful in diagnosis and quantification of OAB syndrome.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlation of incontinence impact questionnaire score in overactive bladder syndrome cases with urodynamic findings

Sharma

Chauhan

Bhatla

et al. 2020

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

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Is urodynamic evaluation able to change and improve the management of women with idiopathic overactive bladder?

Serati

Cantaluppi

Coluccia

et al. 2022

Minerva Urol Nephrol

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Urinary Oxidative Stress Biomarkers in the Diagnosis of Detrusor Overactivity in Female Patients with Stress Urinary Incontinence

2023

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Ninety-three women with urodynamic stress incontinence (USI) and a mean age of 60.8 ± 10.7 (36–83) years were retrospectively enrolled. According to their VUDS, 31 (33%) were grouped into USI and detrusor overactivity (DO), 28 (30.1%) were grouped into USI and hypersensitive bladder (HSB), and 34 (36.6%) were controls (USI and stable bladder). The USI and DO group had significantly increased 8-isoprostane (mean, 33.3 vs. 10.8 pg/mL) and 8-hydroxy-2-deoxyguanosine (8-OHdG; mean, 28.9 vs. 17.4 ng/mL) and decreased interleukin (IL)-2 (mean, 0.433 vs. 0.638 pg/mL), vascular endothelial growth factor (mean, 5.51 vs. 8.99 pg/mL), and nerve growth factor (mean, 0.175 vs. 0.235 pg/mL) levels compared to controls. Oxidative stress biomarkers were moderately diagnostic of DO from controls, especially 8-isoprostane (area under the curve (AUC) > 0.7). Voided volume was highly diagnostic of DO from either controls or non-DO patients (AUC 0.750 and 0.915, respectively). The proposed prediction model with voided volume, 8-OHdG, and 8-isoprostane (cutoff values 384 mL, 35 ng/mL, and 37 pg/mL, respectively) had an accuracy of 81.7% (sensitivity, 67.7%; specificity, 88.7%; positive predictive value, 75.0%; negative predictive value, 84.6%). Combined with voided volume, urinary oxidative stress biomarkers have the potential to be used to identify urodynamic DO in patients with USI.

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Clinical and urodynamic impact of detrusor overactivity in women with overactive bladder

Cited by 3 publications

References 19 publications

Correlation of incontinence impact questionnaire score in overactive bladder syndrome cases with urodynamic findings

Correlation of incontinence impact questionnaire score in overactive bladder syndrome cases with urodynamic findings

Is urodynamic evaluation able to change and improve the management of women with idiopathic overactive bladder?

Urinary Oxidative Stress Biomarkers in the Diagnosis of Detrusor Overactivity in Female Patients with Stress Urinary Incontinence

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