Clinical and Subclinical Intrauterine Infection or Inflammation

Maki, Yuji

doi:10.1007/978-981-13-9875-9_5

Cited by 2 publications

(2 citation statements)

References 74 publications

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“…(17) A previous study concluded that intra-amniotic infection is associated with a signifi cant increase in Matrilysin (MMP-7) in the amniotic fl uid in preterm labor and patients with PPROM without microbial invasion of the amniotic cavity.The MMP-7 values of both groups were increased, microbial invasion of the amniotic cavity was associated with a signifi cant increase in the amniotic fl uid MMP-7 concentration between the two groups. 19,20 The results of this study did not fi nd any signifi cant differences in the features of qualitative serum CRP and serum MMP-7 between preterm and term pregnancies with premature rupture of membranes at the Regional General Hospital Dr. Zainoel Abidin Banda Aceh. Nonetheless, CRP and MMP-7 examinations can be used as markers of potential predisposing factors for PROM and PPROM cases.…”

Section: Discussionmentioning

confidence: 63%

C-Reactive Protein and Matrix Metalloproteinase-7 in Preterm Premature Rupture of Membranes (PPROM) and Premature Rupture of Membranes (PROM)

Rajuddin

Putri

Munawar

2022

Indones J Obstet Gynecol

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Objective: To determine the difference in qualitative serum CRP and MMP-7 levels between PROM and PPROM Methods: Research with a case-control design with premature rupture of membranes in term pregnancy as a control group and preterm pregnancy as a case group conducted in the delivery room of the Regional General Hospital dr. Zainoel Abidin Banda Aceh starting from January 2020. Total number of each group as many as 30 samples that met the inclusion and exclusion criteria by taking venous blood samples to check the levels of qualitative CRP serum and levels of the Metalloproteinase-7 Matrix (MMP-7). Statistical tests for categorical - numerical data groups were tested using independent sample t-test and categorical - categorical data groups were tested using Chi-Square test. Results: A total of 60 samples with 30 PPROM and 30 PROM mothers. There was no statistically significant difference in the qualitative CRP serum result in PROM patients with term and preterm pregnancies. On MMP-7 examination, the mean MMP-7 level of preterm PROM mothers was higher than at term PROM, which was 5.28 mg / L and there was a significant relationship between MMP-7 and qualitative CRP in PROM patients with term pregnancy (p <0.05). Conclusion: There is no significant difference in the value of qualitative CRP and MMP-7 between PPROM and PROM. However, there was a significant association between qualitative serum CRP and plasma MMP-7 in PROM. Keywords: c-reactive protein, matrix metalloproteinase-7,rupture of membranes. Abstrak Tujuan: Untuk mengetahui perbedaan gambaran serum CRP kualitatif dan kadar MMP-7 antara kehamilan preterm dan aterm dengan ketuban pecah dini di RSUD Dr. Zainoel Abidin Banda Aceh. Metode: Penelitian dengan desain kasus kontrol dengan ketuban pecah dini kehamilan aterm sebagai kelompok kontrol dan kehamilan preterm sebagai kelompok kasus. yang dilakukan di Kamar Bersalin Rumah Sakit Umum Daerah dr. Zainoel Abidin Banda Aceh pada Januari 2020. Dengan jumlah masing-masing kelompok sebanyak 30 sampel yang memenuhi kriteria inklusi dan eklusi dengan pengambilan sampel darah vena untuk dilakukan pemeriksaan kadar serum CRP kualitatif dan kadar Matrix Metalloproteinase-7 (MMP-7). Uji statistik untuk kelompok data yang bersifat kategorik - numerik diuji menggunakan uji T tidak berpasangan dan pasangan kelompok data yang bersifat kategorik - katergorik akan diuji menggunakan uji Chi-Square. Hasil: Sebanyak 60 penderita KPD dengan 30 Ibu KPD Preterm dan 30 KPD aterm. Tidak dijumpai perbedaan yang bermakna secara statistik gambaran serum CRP kualitatif pada penderita KPD dengan kehamilan aterm dan preterm. Pada pemeriksaan MMP-7 rerata kadar MMP-7 ibu KPD preterm lebih tinggi dibandingkan KPD aterm yakni senilai 5,28 mg/L dan terdapat hubungan bermakna antara MMP-7 dan CRP kualitatif pada penderita KPD dengan kehamilan aterm (p < 0,05). Kesimpulan: Tidak terdapat perbedaan gambaran signifikan nilai CRP kualitatif dan MMP-7 antara KPD preterm dan aterm. Namun, terdapat hubungan yang signifikan antara serum CRP kualitatif dan MMP-7 plasma pada penderita ketuban pecah dini dengan kehamilan aterm. Kata kunci: c-reactive protein, matrix metalloproteinase-7, ketuban pecah dini.

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Section: Discussionmentioning

confidence: 63%

C-Reactive Protein and Matrix Metalloproteinase-7 in Preterm Premature Rupture of Membranes (PPROM) and Premature Rupture of Membranes (PROM)

Rajuddin

Putri

Munawar

2022

Indones J Obstet Gynecol

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“… 27 Respiratory distress syndrome (RDS) is diagnosed based on clinical signs (tachypnea, grunting, retractions, nasal flaring, and cyanosis) and confirmed by chest x-ray showing a reticulogranular pattern or requiring surfactant administration. 28 Patent ductus arteriosus (PDA) is confirmed by echocardiography showing left-to-right shunt through the ductus arteriosus. 29 Intraventricular hemorrhage (IVH) is diagnosed and graded by cranial ultrasound, typically using the Papile grading system (Grade I-IV).…”

Section: Methodsmentioning

confidence: 99%

A cross-sectional analysis of preterm birth incidence and survival in Al Kharj, Saudi Arabia

Alghadier,

Alasraj,

Elnaggar

et al. 2024

SMJ

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Objectives: To understand the prevalence and survival rates of preterm birth (PTB) is of utmost importance in informing healthcare planning, improving neonatal care, enhancing maternal and infant health, monitoring long-term outcomes, and guiding policy and advocacy efforts. Methods: The medical records of preterm infants admitted to the Neonatal Intensive Care Unit (NICU) with a diagnosis of prematurity at the Maternity and Children’s Hospital (MCH), Al Kharj, Saudi Arabia, were reviewed between January 2018 and December 2022. Data were collected on birth weight (BW), gender, number of live births, gestational age, mortality, nationality, APGAR score, length of stay in the NICU, and maternal details. Results: A total of 9809 live births were identified between 2018 and 2022, of which 139 (3.9%) were born preterm. The overall mortality rate of the included sample was 7.19%, whereas the mortality rate according to BW was 38.4% of those born with extremely low birth weight (ELBW). The most common intrapartum complications were malpresentation (15.1%), placental complications (4.3%), and cord complications (3.6%). Conclusion: This study provides valuable insights into the prevalence of PTB in the country, particularly focusing on the vulnerability of extremely preterm babies.

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Clinical and Subclinical Intrauterine Infection or Inflammation

Cited by 2 publications

References 74 publications

C-Reactive Protein and Matrix Metalloproteinase-7 in Preterm Premature Rupture of Membranes (PPROM) and Premature Rupture of Membranes (PROM)

C-Reactive Protein and Matrix Metalloproteinase-7 in Preterm Premature Rupture of Membranes (PPROM) and Premature Rupture of Membranes (PROM)

A cross-sectional analysis of preterm birth incidence and survival in Al Kharj, Saudi Arabia

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