Clinical and social consequences of buerger disease

Ohta, Takashi; Ishioashi, Hiroyuki; Hosaka, Minoru; Sugimoto, Ikuo

doi:10.1016/j.jvs.2003.08.006

Cited by 116 publications

(130 citation statements)

References 7 publications

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“…Although successful bypass surgery dramatically improves symptoms of ischemia, it has poor long-term results and is not frequently applicable in the case of Buerger's disease. The results of arterial reconstruction using UCB-derived MSCs were better than others reported by Ohta et al and Sasajima et al [5,24]. This study showed that arterial reconstruction or prevention of arterial obstruction using UCB-derived MSCs completely controls the rest pain and shortens the healing process of ischemic ulcers.…”

Section: Discussionsupporting

confidence: 47%

Successful Stem Cell Therapy Using Umbilical Cord Blood-Derived Multipotent Stem Cells for Buerger's Disease and Ischemic Limb Disease Animal Model

Han²,

et al. 2006

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Buerger's disease, also known as thromboangiitis obliterans, is a nonatherosclerotic, inflammatory, vasoocclusive disease. It is characterized pathologically as a panangiitis of medium and small blood vessels, including both arteries and adjacent veins, especially the distal extremities (the feet and the hands). There is no curative medication or surgery for this disease. In the present study, we transplanted human leukocyte antigenmatched human umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) into four men with Buerger's disease who had already received medical treatment and surgical therapies. After the stem cell transplantation, ischemic rest pain suddenly disappeared from their affected extremities. The necrotic skin lesions were healed within 4 weeks. In the follow-up angiography, digital capillaries were increased in number and size. In addition, vascular resistance in the affected extremities, compared with the preoperative examination, was markedly decreased due to improvement of the peripheral circulation. Because an animal model of Buerger's disease is absent and also to understand human results, we transplanted human UCB-derived MSCs to athymic nude mice with hind limb ischemia by femoral artery ligation. Up to 60% of the hind limbs were salvaged in the femoral artery-ligated animals. By in situ hybridization, the human UCB-derived MSCs were detected in the arterial walls of the ischemic hind limb in the treated group. Therefore, it is suggested that human UCBderived MSC transplantation may be a new and useful therapeutic armament for Buerger's disease and similar ischemic diseases.

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Section: Discussionsupporting

confidence: 47%

Successful Stem Cell Therapy Using Umbilical Cord Blood-Derived Multipotent Stem Cells for Buerger's Disease and Ischemic Limb Disease Animal Model

Han²,

et al. 2006

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“…Taking TAO cases as an example, these patients represent the vast majority of AICLI patients and can be treated by many methods, including surgical bypass, endarterectomy, embolectomy, sympathectomy, superficial vein arterialization, PTA, thrombolysis, and stenting; however, none of these methods provide ideal mid‐ to long‐term efficacy. Without cell therapy, the major amputation rate of TAO patients, including CLI and claudicants, has been reported to be as high as 12%–31% 20, 21, 22. Ohta et al observed that 118 TAO patients presented a total major amputation rate of 19%; moreover, this study revealed that the primary patency rates of the surgical bypass subgroup were 41% (1 year), 32% (5 years), and 30% (10 years), respectively, and the secondary patency rates of this group were 54% (1 year), 47% (5 years), and 39% (10 years), respectively.…”

Section: Discussionmentioning

confidence: 99%

A Five-Year Study of the Efficacy of Purified CD34+ Cell Therapy for Angiitis-Induced No-Option Critical Limb Ischemia

Fang

Wei

Chen

et al. 2018

Stem Cells Translational Medicine

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Angiitis‐induced critical limb ischemia (AICLI) patients constitute a remarkable proportion of no‐option critical limb ischemia (CLI) patients. Stem cell therapy has become an innovative and promising option for no‐option CLI patients. As one of these promising stem cell therapies, purified CD34+ cell transplantation (PuCeT) has shown favorable short‐term results. However, the long‐term efficacy of PuCeT has yet to be reported. This study evaluates the long‐term efficacy of PuCeT in AICLI patients. Twenty‐seven AICLI patients were enrolled from May 2009 to December 2011. Granulocyte colony‐stimulating factor (G‐CSF) and enoxaparin sodium were administered for 5 days. On day 5, CD34+ cell isolation was performed, and cells were transplanted by intramuscular injection. The primary endpoint, major‐amputation‐free survival rate (MAFS), as well as secondary endpoints, such as peak pain‐free walking time (PPFWT) and the Wong‐Baker FACES pain rating scale score (WFPRSS), were routinely evaluated during the 5‐year follow‐up period. The endpoints were as follows: the MAFS was 88.89%; PPFWT increased from 3 ± 3 to 17 ± 6 minutes; WFPRSS decreased from 7 ± 2 to 0.3 ± 1.7; the ulcer healing rate was 85.71%; the recurrence rate was 11.11%; and SF‐36v2 scores were significantly improved at 5 years after PuCeT. The rate of labor recovery 5 years after PuCeT was 65.38%, and no severe adverse effect was observed during the treatment. PuCeT demonstrated long‐term efficacy and durability as a treatment of AICLI not only in achieving limb salvage but also in recovering the labor competence and improving the quality of life of patients. Stem Cells Translational Medicine 2018;7:583–590

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“…Complete abstinence from smoking is critical for success of available therapy [2,12]. Early treatment is also important to avoid social problems and improve quality of life [17].…”

Section: Discussionmentioning

confidence: 99%

Buerger’s Disease (Thromboangiitis Obliterans)- Management by Ilizarov’s Technique of Horizontal Distraction. A Retrospective Study of 60 Cases

Patwa¹,

Krishnan

2010

Indian J Surg

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In Buerger's disease conservative treatment is questionable. Arterial reconstructive surgery is not feasible and sympathectomy has limited role. Progression of the disease invariably leads to amputation. Ilizarov's method increases the vascularity of the ischaemic limb. Retrospective analysis of Ilizarov's technique in 60 patients was done. Immediate results took into account rest pain, colour of skin, venous return, temperature, pulse oxymeter measured oxygen saturation and ulcer/amputation stump wound healing. Early and late results took into account rest pain, healing of ulcers/amputation stump with or without plastic coverage, claudication distance, resumption of previous occupation and domestic ambulation. The mean follow up of patients was 63 months. Immediate results were promising except two amputations. Early result were excellent to good in 56 and late results were excellent to good in 48 patients. Deterioration had significant correlation with smoking. Ilizarov's method is an excellent and cheap procedure in treatment of Buerger's disease.

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Clinical and social consequences of buerger disease

Cited by 116 publications

References 7 publications

Successful Stem Cell Therapy Using Umbilical Cord Blood-Derived Multipotent Stem Cells for Buerger's Disease and Ischemic Limb Disease Animal Model

Successful Stem Cell Therapy Using Umbilical Cord Blood-Derived Multipotent Stem Cells for Buerger's Disease and Ischemic Limb Disease Animal Model

A Five-Year Study of the Efficacy of Purified CD34+ Cell Therapy for Angiitis-Induced No-Option Critical Limb Ischemia

Buerger’s Disease (Thromboangiitis Obliterans)- Management by Ilizarov’s Technique of Horizontal Distraction. A Retrospective Study of 60 Cases

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