Clinical and radiological outcome of the treatment of osteonecrosis of the femoral head using the osteonecrosis intervention implant

Floerkemeier, Thilo; Thorey, Fritz; Daentzer, Dorothea; Lerch, Matthias; Klages, Phillip; Windhagen, Henning; Lewinski, Gabriela von

doi:10.1007/s00264-009-0940-9

Cited by 62 publications

(66 citation statements)

References 17 publications

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“…[32][33][34] Since joint preserving procedures for advanced stages of AVN are limited, early diagnosis and effective treatment are necessary. 35,36 The vasoactive, stable prostacyclin analogue iloprost is approved for therapy of critical limb ischemia due to peripheral arteriosclerotic obliterative disease and diabetic angiopathy as well as an inhalative for patients with pulmonary arterial hypertension. 37 Our group and others use iloprost for the treatment of early stages of AVN.…”

Section: Rule Out Other Factors Of Hip Painmentioning

confidence: 99%

Magnetic resonance imaging of hip joint cartilage and labrum

Zilkens¹,

Miese²,

Jäger³

et al. 2011

Orthop Rev (Pavia)

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Hip joint instability and impingement are the most common biomechanical risk factors that put the hip joint at risk to develop premature osteoarthritis. Several surgical procedures like periacetabular osteotomy for hip dysplasia or hip arthroscopy or safe surgical hip dislocation for femoroacetabular impingement aim at restoring the hip anatomy. However, the success of joint preserving surgical procedures is limited by the amount of preexisting cartilage damage. Biochemically sensitive MRI techniques like delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) might help to monitor the effect of surgical or nonsurgical procedures in the effort to halt or even reverse joint damage.

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Section: Rule Out Other Factors Of Hip Painmentioning

confidence: 99%

Magnetic resonance imaging of hip joint cartilage and labrum

Zilkens¹,

Miese²,

Jäger³

et al. 2011

Orthop Rev (Pavia)

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“…The p.G1170S mutation, in contrast with the most missense mutations, only leads to milder phenotypes confined to the hip joint, without involvement of spinal or ocular abnormalities [5][6][7]. Furthermore, the phenotypes of p.G1170S were ANFH/ hip OA/LCP disease, which were thought to be diseases with multiple aetiologies [14,15] and requiring various treatment strategies [16][17][18]. Hence, studying the histological and ultrastructural characteristics of mutant cartilage with the p.G1170S mutation will help to understand the pathogenesis of this new type II collagenopathy, as well as ANFH/hip OA/LCP disease.…”

Section: Introductionmentioning

confidence: 99%

A histological and ultrastructural study of femoral head cartilage in a new type II collagenopathy

Zhang²,

Peng³

et al. 2010

International Orthopaedics (SICOT)

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A new type II collagenopathy, caused by the p. Gly1170Ser mutation of COL2A1, which presents as premature hip osteoarthritis (OA), avascular necrosis of the femoral head (ANFH) or Legg-Calvé-Perthes (LCP) disease, was recently found in several families with an inherited disease of the hip joint. In this study, femoral head cartilage was harvested for histological and ultrastructural examination to determine the pre-existing generalised abnormalities of the mutant cartilage. The histological results showed that the hierarchical structure of the mutant cartilage and the embedded chondrocytes were markedly abnormal. The expression and distribution of type II collagen was non-uniform in sections of the mutant cartilage. Ultrastructural examination showed obvious abnormal chondrocytes and disarrangement of collagen fibres in the mutant cartilage. Furthermore, the predicted stability of type II collagen dramatically decreased with the substitution of serine for glycine. Our study demonstrated that the p.Gly1170Ser mutation of COL2A1 caused significant structural alterations in articular cartilage, which are responsible for the new type II collagenopathy.

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“…There have been attempts to use various adjunctive therapies with this procedure such as the following: (1) bone grafting [13,23,26]; (2) addition of mesenchymal cells [13,23,26]; and (3) tantalum rod insertion [9,11,[36][37][38][39][40][41].…”

Section: Overall Outcomes Of Traditional Core Decompressionmentioning

confidence: 99%

A current review of core decompression in the treatment of osteonecrosis of the femoral head

Pierce

Jauregui

Elmallah

et al. 2015

Curr Rev Musculoskelet Med

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The review describes the following: (1) how traditional core decompression is performed, (2) adjunctive treatments, (3) multiple percutaneous drilling technique, and (4) the overall outcomes of these procedures. Core decompression has optimal outcomes when used in the earliest, precollapse disease stages. More recent studies have reported excellent outcomes with percutaneous drilling. Furthermore, adjunct treatment methods combining core decompression with growth factors, bone morphogenic proteins, stem cells, and bone grafting have demonstrated positive results; however, larger randomized trial is needed to evaluate their overall efficacy.

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Clinical and radiological outcome of the treatment of osteonecrosis of the femoral head using the osteonecrosis intervention implant

Cited by 62 publications

References 17 publications

Magnetic resonance imaging of hip joint cartilage and labrum

Magnetic resonance imaging of hip joint cartilage and labrum

A histological and ultrastructural study of femoral head cartilage in a new type II collagenopathy

A current review of core decompression in the treatment of osteonecrosis of the femoral head

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