Clinical and radiological features related to the growth potential of meningioma

Abstract

Clinical and radiological features that help predict the growth potential of meningioma would be beneficial. The purpose of this study is to clarify the characteristics related to proliferating potential using the MIB-1 staining index. We analyzed the relationship of MIB-1 staining indices to characteristics of 342 consecutive patients with meningioma surgically removed between 1995 and 2004 by logistic regression analysis. One hundred and forty-nine of the patients with meningioma were ≥60 in age; 89 male; 48 recurrent; 203 symptomatic; 157 at the skull base; 124 over 20 cm 3 ; 24 multiple; 136 with edema; 117 with calcification. The MIB-1 staining index in 56 of 296 grade I meningiomas in WHO classification was ≥ 3.0; in 27 of 28 grade II; and in 17 of 18 grade III, respectively. Logistic regression analysis demonstrated that male (odds ratio [OR], 2.374, p=0.003), recurrence (OR, 7.574, p=0.0001), skull base (OR, 0.540, p=0.035), calcification (OR, 0.498, p=0.019) were independent risk factors for a high MIB-1 staining index (≥3.0); age, symptomatic, volume, multiple, edema were not. Male, recurrence, non-skull base, absence of calcification are independent risk factors for a high proliferative potential. These should be taken into consideration when managing meningiomas.

Clinical features and surgical management of intracranial meningiomas in the elderly

“…Other studies have reported that hyperintensity on T2-weighted imaging, a non-skull base location and the absence of calcification on imaging are considered positive indicators of tumor growth in intracranial meningiomas (30,31). In addition, a non-skull base location and the absence of calcification correlate with a high tumor proliferation index (MIB-1) in intracranial meningiomas (32)(33)(34)(35). To determine the MIB-1 staining index, the number of cells stained positively with MIB-1 and the total number of cells were counted in several representative fields containing >1,000 cells, and the ratio was defined as the MIB-1 staining index.…”

Expression of stem cell marker nestin and microrna-21 in meningiomas

“…Some remain unaltered in size for a long period, while others tend to grow fast (10). Surgical resection remains the treatment mainstay (1,24).…”

Correlation of p63 protein expression and Ki-67 labelling index with histological grades of meningiomas: A five years study

“…Kasuya et al 10 reported that male gender was an independent risk factor for high proliferative potential. The mean Ki-67 LI and p63 with respect to age and gender was not statistically significant in our series.…”

“…Most meningiomas occur in adults between the ages of 20 to 60 years, with a peak incidence around 4 th decade of life. 1 Meningiomas most likely occur in women with ratio of female to male 2:1 intracranially and 1:10 intraspinally.…”

“…Many immunohistochemical markers have been suggested in the literature to aid in the diagnosis of meningiomas. Markers like Ki-67 1,4,5 p63, 6 Claudin, 7 and the absence of progesterone receptors have been mentioned in the literature. Definitive diagnosis based on using single immunohistochemical marker may be difficult at times.…”