Clinical and radiological features of Mycobacterium kansasii and other NTM infections

Matveychuk, Alona; Fuks, Leonardo; Priess, Rachel; Hahim, Ilanit; Shitrit, David

doi:10.1016/j.rmed.2012.06.023

Cited by 62 publications

(66 citation statements)

References 20 publications

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“…In the present study, one-fourth of M. simiaeinfected patients had disseminated disease; all of them were HIV-positive and had low CD4 ＋ counts. This finding is in agreement with those of previous studies (7,24,25). The clinical presentation, radiographic findings, and utility of sputum-based diagnostic modalities may differ between HIV-positive and -negative cases and may differ in HIV-infected individuals as immune suppression progresses (1,26).…”

Section: Discussionsupporting

confidence: 91%

Mycobacterium simiae: a Possible Emerging Pathogen in Iran

et al. 2013

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SUMMARY: Mycobacterium simiae has been reported worldwide, particularly from the Middle East. This organism has been recognized as a causative agent of pulmonary and disseminated infections. In this study, we used molecular methods to detect this organism from patients who were suspected of having tuberculosis. A total of 117 isolates of mycobacteria were evaluated from different regions of Iran. Isolates were identified using phenotypic methods and gene sequencing of 16S rRNA, rpoB, hsp65, and ITS. Of the 117 isolates, 12 M. simiae isolates (10.2z) were identified from different clinical samples, including bronchoalveolar lavage and sputum (n ＝ 8), blood (n ＝ 3), and lymph node biopsy (n ＝ 1). Three isolates (3/12, 25z) were recovered from blood samples of HIV cases when the CD4 ＋ count was less than 50/ml. There was no significant relationship between infection and age or gender. Infection with nontuberculous mycobacteria (NTM), including M. simiae, is the major problem among immunocompromised patients. The results of this study illustrated the importance of molecular methods for accurate and rapid detection of NTM infections in the treatment of nonresponding patients with suspected tuberculosis.

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Section: Discussionsupporting

confidence: 91%

Mycobacterium simiae: a Possible Emerging Pathogen in Iran

et al. 2013

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“…The incidence of cavity formation has been considered high in patients with pulmonary M. kansasii diseases well as in previous reports from Japan [4]. However, more recent studies reported incidence rates from 32% to 54% [12] [13] [14]. This discrepancy in the incidence cavity formation may be explained by recent improvements in the diagnostic methods used (bronchoscopy, etc.)…”

Section: Discussionmentioning

confidence: 94%

“…Regarding CT findings of pulmonary M. kansasii disease, they can be summarized as follows: 1) the distribution of lesions was most frequent in the upper lobe and bilateral lung field; 2) the extent of lesions was limited within the unilateral lung field; 3) infiltration shadows or small centrilobular nodules with bronchiectasis were recognized in over half of all patients, and 4) typical radiological findings such as cavities (thin-walled cavities) were recognized in over half of all patients [12] [13] [14]. The propensity of pulmonary lesions to affect the upper lobe in pulmonary M. kansasii disease was similar to that of Mycobacterium tuberculosis (MTB) [15].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Mycobacterium kansasii Disease in Previously Healthy Women

Kobashi¹,

Abe²,

Mouri³

et al. 2016

JTR

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We encountered two cases of pulmonary M. kansasii disease in two women without underlying diseases in our hospital. Case 1 was a 52-year-old woman who visited with an abnormal chest shadow. She showed nodular and linear shadows with bronchiectatic changes and small cavities in the left upper lobe and lingula, and was diagnosed with pulmonary M. kansasii disease because M. kansasii was isolated from her bronchoscopic specimens. Case 2 was a 33-year-old woman who visited with a productive cough. She showed several cavity lesions in the right lung, and was diagnosed with pulmonary M. kansasii disease from several isolated sputum samples.Combination therapy using INH, RFP, and EB was effective treatment for the two cases. Because pulmonary M. kansasii disease in previously healthy women shows various radiological patterns, it was considered important to perform acid-fast bacilli examination using clinical specimens in order to decide on the appropriate treatment methods. KeywordsPulmonary M. kansasii Disease, Women

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“…It is the second most common NTM in Japan. While the radiological features of M. kansasii may not be very different from those of other NTM, Takahashi et al and Matveychuk et al reported that cavitation on the right upper lobe is characteristic of pulmonary infection with M. kansasii 5,6 . In our patient, a cavity was also found in the right upper lobe.…”

Section: Cs Cycloserine 30smentioning

confidence: 99%

A Case of Pneumothorax Complicated by Multiple Large Pulmonary Nodules Due to Mycobacterium Kansasii Infection

Satoshi:筆頭著者:責任著者

Takeda

Miyata

et al. 2015

Showa Univ J Med Sci

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: We report a rare case of pulmonary infection with Mycobacterium kansasii complicated by pneumothorax and multiple large nodules in both lungs. A 68-year-old man presented with sudden right chest pain and dyspnea. He was diagnosed with pneumothorax on the right side and immediately treated by insertion of a chest tube and drainage. After admission, the pneumothorax was cured, but a high fever continued. A chest x-ray and computed tomography scan showed multiple large nodules with and without cavities in both lungs. We suspected malignant disease, inflammatory granulomatosis, or pneumomycosis and subsequently performed broncho berscopy. The results of a transbronchial lung biopsy indicated caceous necrosis surrounded by epithelioid cells, without forming distinct granulomas on histology, and the results of acid-fast bacilli smear tests were positive. Mycobacterium could not be detected by polymerase chain reaction. Because the patient s condition was poor, we started him on anti-Mycobacterium therapy : rifampin, isoniazid, and ethambutol. His condition subsequently improved. Bacterial culture con rmed the presence of M. kansasii, so the antibiotic therapy was continued. The patient s temperature decreased to below 37 C, and the nodules in his lungs reduced in size. In this atypical case of M. kansasii infection, the patient presented with severe symptoms. Broncho berscopy enabled prompt diagnosis and early treatment.

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Clinical and radiological features of Mycobacterium kansasii and other NTM infections

Abstract: Major differences in the epidemiologic and clinical features of M. kansasii infection and other NTM have important diagnostic and clinical implications.

Cited by 62 publications

References 20 publications

<i>Mycobacterium simiae</i>: a Possible Emerging Pathogen in Iran

<i>Mycobacterium simiae</i>: a Possible Emerging Pathogen in Iran

Pulmonary <i>Mycobacterium kansasii</i> Disease in Previously Healthy Women

A Case of Pneumothorax Complicated by Multiple Large Pulmonary Nodules Due to <i>Mycobacterium Kansasii</i> Infection

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Clinical and radiological features of Mycobacterium kansasii and other NTM infections

Abstract: Major differences in the epidemiologic and clinical features of M. kansasii infection and other NTM have important diagnostic and clinical implications.

Cited by 62 publications

References 20 publications

<i>Mycobacterium simiae</i>: a Possible Emerging Pathogen in Iran

<i>Mycobacterium simiae</i>: a Possible Emerging Pathogen in Iran

Pulmonary &lt;i&gt;Mycobacterium kansasii&lt;/i&gt; Disease in Previously Healthy Women

A Case of Pneumothorax Complicated by Multiple Large Pulmonary Nodules Due to <i>Mycobacterium Kansasii</i> Infection

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Pulmonary <i>Mycobacterium kansasii</i> Disease in Previously Healthy Women