Clinical and radiological characteristics of brain abscess due to different organisms in hospitalized patients: A 6-year retrospective study from China

Su, Jiachun; Hu, Bin; Zhang, Yixin; Liu, Ying

doi:10.1016/j.heliyon.2023.e16003

Cited by 3 publications

(2 citation statements)

References 35 publications

(45 reference statements)

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“… 14 The study of Huashan Hospital showed that the pus wall thickness of single brain abscess caused by P. aeruginosa was thicker than that of other bacteria, and the edema was more obvious, but the difference in diameter of abscess was not statistically significant. 15 The case we studied was multiple brain abscesses with wide distribution and large number, consider that this may be an imaging feature associated with intermediate streptococcus, which may help in early diagnosis.…”

Section: Discussionmentioning

confidence: 99%

A Report of Two Cases of Meningoencephalitis Caused by Streptococcus intermedius

Pan,

Wu,

Zeng

et al. 2024

IDR

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Objective In this paper, we analyzed the clinical data of patients with meningoencephalitis caused by Streptococcus intermedius to understand better the clinical characteristics of the disease and recommend auxiliary diagnostic mode as well as treatment experience. Methods We reviewed the clinical data of two patients admitted to our department in 2019 with meningoencephalitis caused by S. intermedius . Results Two female patients were examined, one of whom had a history of radiotherapy for nasopharyngeal carcinoma while the other had no underlying disease. These two patients were admitted with symptoms of meningoencephalitis. Cerebrospinal fluid examinations revealed elevated levels of leukocytes and protein. After treatment with meropenem, the condition improved for a brief time, but then worsened with a decline in mental status and limb movement. Blood and cerebrospinal fluid cultures demonstrated the absence of pathogenic bacteria, while genome sequencing of cerebrospinal fluids revealed the presence of S. intermedius . Cranial magnetic resonance imaging revealed multiple cerebral abscesses (CAs). After coadministration of linezolid as an anti-infective, clinical symptoms gradually improved, and the CAs shrank on follow-up imaging. The condition exhibited a pattern of improvement-deterioration-improvement. Conclusion Meningoencephalitis caused by S. intermedius is complex and prone to fluctuation and formation of multiple CAs. The definitive clinical diagnosis of this disease can be aided by genome sequencing technology, and early clarification of the etiology combined with the use of potent antibiotics is effective.

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Section: Discussionmentioning

confidence: 99%

A Report of Two Cases of Meningoencephalitis Caused by Streptococcus intermedius

Pan,

Wu,

Zeng

et al. 2024

IDR

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“…The most common bacteria that contribute to brain abscess are mainly Streptococcus and Staphylococcus species (Brouwer et al, 2014a,b). The causative pathogens are associated with geographic locations, patient's age, medical conditions, and primary infection (Su et al, 2023); thus, the spectrum of microorganisms should be considered broad. Fusobacterium nucleatum is a gram-negative anaerobic bacteria that exists abundantly in the human oral cavity and gastrointestinal tract (Stokowa-Sołtys et al, 2021;Chen Y. et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Case report: Two case reports of cryptogenic brain abscess caused by Fusobacterium nucleatum and literature review

Zhang,

Liu,

et al. 2023

Front. Neurosci.

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Brain abscess originates from a localized cerebritis area of brain parenchyma, remaining a refractory infectious disease in the central nervous system. Causative pathogens can be wide-ranging, including bacteria, fungi, or parasites; thus, precise pathogen identification and individualized antimicrobial therapy determine patients’ outcomes. Here, we report two cases where both patients only presented with limb dysfunction, but without symptoms, signs, or biological evidence of infection. Samples were obtained through brain stereoscopic surgeries and microbial identifications were performed to confirm the infection of Fusobacterium nucleatum. Further appropriate treatments were given, and the patients recovered well. Patient 1 was a 73-year-old male with a 20-day history of left-sided limbs weakness. A brain MRI showed a space-occupying lesion with a heterogeneously ring-enhancement character in the right frontal lobe. This patient underwent puncture biopsy of the lesion with robot-assisted guidance to confirm a brain abscess. Empirical antibiotic therapy was immediately given until the pathogen was identified as Fusobacterium nucleatum; thus, he received specific antibiotic therapy with metronidazole and recovered well after treatment. Patient 2 was a 22-year-old female with heart disease history who complained of right-sided limb weakness for nine days. A brain MRI showed a circular enhanced lesion with a thin capsule wall and surrounding edema in the left frontal lobe. This patient underwent puncture drainage of the lesion with robot-assisted guidance and a brain abscess was confirmed. Empirical antibiotic therapy was given until the pathogen was identified as Fusobacterium nucleatum and then she also received metronidazole treatment. Her symptoms recovered and the lesion disappeared after 1 month. Hence, we reviewed the diagnosis and treatment of cryptogenic brain abscess caused by Fusobacterium nucleatum and highlight that precise neurosurgical interventions and identification of causative pathogens are crucial for the management of brain abscess.

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Profiles of primary brain abscesses and their impact on survival: An international ID-IRI study

Sahin,

Mert,

Emecen

et al. 2024

International Journal of Infectious Diseases

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Clinical and radiological characteristics of brain abscess due to different organisms in hospitalized patients: A 6-year retrospective study from China

Cited by 3 publications

References 35 publications

A Report of Two Cases of Meningoencephalitis Caused by Streptococcus intermedius

A Report of Two Cases of Meningoencephalitis Caused by Streptococcus intermedius

Case report: Two case reports of cryptogenic brain abscess caused by Fusobacterium nucleatum and literature review

Profiles of primary brain abscesses and their impact on survival: An international ID-IRI study

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