Clinical and radiologic spectrum of corpus callosum infarctions: Clues to the etiology

Etiology of Corpus Callosum Lesions with Restricted Diffusion

“…Previous case series examining the etiology of infarcts in the CC have suggested that large artery atherosclerosis is responsible for infarction in the anterior portion of the CC, whereas embolic events are more likely in the posterior CC (3,6,9). In our study, splenial lesions with restricted diffusion were most likely due to an atypical vascular mechanism, such as vasculopathy or hypercoagulability.…”

“…Based on the current literature, there is uncertainty surrounding the characteristics of CC infarcts. Some studies have suggested that the genu and body of the callosum are at greatest risk, [3,5,[7][8][9] and others suggested the splenium [6]. The most likely vascular etiology has been variably reported as small-vessel disease, large-vessel atherosclerosis, and cardioembolism [5,6,9].…”

“…Some studies have suggested that the genu and body of the callosum are at greatest risk, [3,5,[7][8][9] and others suggested the splenium [6]. The most likely vascular etiology has been variably reported as small-vessel disease, large-vessel atherosclerosis, and cardioembolism [5,6,9]. Prior studies are limited by their small size, generally fewer than 10 cases, and only a subset of these studies applied a mechanism-based classification system [5,9].…”

Delayed Cerebral Ischemia of the Corpus Callosum: A Case Report

“…The predilection of DCI infarctions to affect vessels supplying the corpus callosum, in particular, is unique given that ischemia of the corpus callosum is an incredibly rare condition that has been infrequently reported [6][7][8][9][10][11]. The paucity of such infarctions is due to the rich vascular supply of the corpus callosum, which is derived from both the anterior and posterior cerebral circulation from each hemisphere.…”

“…The predilection of DCI infarctions to affect vessels supplying the corpus callosum, in particular, is unique given that the corpus callosum receives a rich vascular supply from both the anterior and posterior cerebral circulation. As such, ischemia of the corpus callosum is a rare condition that has been infrequently reported [6][7][8][9][10][11]. Here, we present the case of a 29-year-old male who suffered a hypertensive ICH with significant extension into the ventricular system and subsequently developed DCI with an infarction affecting the body of the corpus callosum several days later.…”