Clinical and radiologic spectrum of glandular odontogenic cysts: A multicenter study of 92 cases

Smit, Chané; Robinson, Liam; Roza, Ana Luiza Oliveira Corrêa; Ker-Fox, Jason; Gomes, Nathalia Rodrigues; Fonseca, Felipe Paiva; Santos‐Silva, Alan Roger; Romañach, Mário José; Vargas, Pablo Agustı́n; Heerden, W.F.P. Van

doi:10.1016/j.oooo.2021.11.008

Cited by 2 publications

(6 citation statements)

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“…It usually presents in the 5 th decade of life. In accordance with Robinson et al (7) the average age of presentation was 46 years and lesions of the upper jaw occurred at a younger age. Fowler et al (8) found that the average age at which the cyst was diagnosed was 51 years (ranging from 20 to 82), although Faisal et al ( 9) described a histologically confirmed GOC case in an 11-yearold patient.…”

Section: Epidemiologysupporting

confidence: 83%

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Glandular odontogenic cyst—a review of characteristic features, treatment, and recurrence

Rogova,

Georgiev

2023

Scripta Scientifica Medicinae Dentalis

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INTRODUCTION:The glandular odontogenic cyst is classified as a developmental epithelial odontogenic cyst and defined as "arising in the tooth-bearing areas of the jaws and characterized by an epithelial lining with cuboidal or columnar cells both at the surface and lining crypts or cyst-like spaces within the thickness of the epithelium". AIM: This review outlines the epidemiology, clinical and radiological presentation, histological characteristics, additional markers aiding in the correct diagnosis, treatment modalities, and recurrence rates of glandular odontogenic cysts. MATERIALS AND METHODS:For the purpose of this review, literature reviews and case reports with included literature reviews from the Scopus, PubMed, and ScienceDirect databases were used. The bibliography of the selected articles was additionally analyzed. RESULTS:The glandular odontogenic cyst is a relatively rare entity, clinically and radiographically nonspecific. It is often misdiagnosed because of its overlapping histopathological features with other odontogenic cysts such as lateral periodontal or botryoid cyst, dentigerous and radicular cysts with mucous metaplasia, and central mucoepidermoid carcinoma. Regarding the treatment, both conservative and radical methods may be applied. These cysts have a high propensity for recurrence and display an aggressive behavior.CONCLUSION: Clinically and radiographically glandular odontogenic cysts can resemble several other lesions of the jaws, which denotes the importance of a precise histopathological diagnosis. The choice of treatment should be based on the degree of aggressive behavior of the cyst. Meticulous examination, appropriate treatment planning, and sufficient follow-up periods are key to a successful outcome.

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Section: Epidemiologysupporting

confidence: 83%

“…Different authors have established a predilection for mandibular localization (approximately 3:1 mandible to maxilla ratio), particularly in the anterior region (7)(8)(9)(11)(12)(13)(14). In 3 cases by Noffke and Raubenheimer where the maxilla was involved, the globulomaxillary region tended to be affected (15).…”

Section: Clinical and Radiological Featuresmentioning

confidence: 99%

Glandular odontogenic cyst—a review of characteristic features, treatment, and recurrence

Rogova,

Georgiev

2023

Scripta Scientifica Medicinae Dentalis

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“…The cyst shows no gender predilection [13][14][15][16]. It has been reported that in South African population GOCs has a strong male predominance which may reflect the difference in gender distribution in different population groups [14,17].…”

Section: Demographicmentioning

confidence: 83%

Section: Demographicmentioning

confidence: 99%

“…GOCs occurs most commonly in middle-aged adults, with highest prevalence at fifth and sixth decades of life [13][14][15][16], however, there are also reports in paediatric patients [15]. The cyst shows no gender predilection [13][14][15][16]. It has been reported that in South African population GOCs has a strong male predominance which may reflect the difference in gender distribution in different population groups [14,17].…”

Section: Demographicmentioning

confidence: 99%

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Glandular Odontogenic Cyst: a Case Report and Literature Review

Gorgis,

Christian Krarup,

Reibel

et al. 2023

JOMR

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Background:The glandular odontogenic cyst is now a well-known entity comprising < 0.5% of all odontogenic cysts with a recent review tabulating about 200 cases in the English literature. Glandular odontogenic cyst shows epithelial features that simulate salivary gland or glandular differentiation. The importance of glandular odontogenic cyst relates to the fact that it has a high recurrence rate and shares overlapping histologic features with central mucoepidermoid carcinoma. The purpose of this paper is to describe the clinical, radiological, and histopathological features of a case of glandular odontogenic cyst with the course of treatment and 9-years follow-up, followed by a review of the literature. Methods: A 63-year-old male was referred for further investigation of a mandibular radiolucency observed by his general dental practitioner. The main complaint was a murmuring sensation in the lower jaw right side. Radiological examination revealed a well-defined, unilocular, radiolucent lesion, involving the right mandible with 17 and 68 mm in mediolaterally and anteroposterior dimension, respectively. Results: A total enucleation of the cystic lesion and surgical extraction of tooth #46, #47 and #48, was performed under local anaesthesia. Histopathologic examination revealed a glandular odontogenic cyst. Conclusions: Glandular odontogenic cyst shows no pathognomonic clinico-radiographic characteristics, and therefore in many cases it resembles a wide spectrum of lesions. Diagnosis can be extremely difficult due to histopathological similarities with dentigerous cyst, lateral periodontal cyst and central mucoepidermoid carcinoma. Therefore a careful histopathological examination and a long-term follow-up (preferably seven years) are required to rule out recurrences.

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Clinical and radiologic spectrum of glandular odontogenic cysts: A multicenter study of 92 cases

Cited by 2 publications

References 25 publications

Glandular odontogenic cyst—a review of characteristic features, treatment, and recurrence

Glandular odontogenic cyst—a review of characteristic features, treatment, and recurrence

Glandular Odontogenic Cyst: a Case Report and Literature Review

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