Clinical and radiographic evaluation of acemannan as direct pulp capping material in young permanent teeth

Abstract

Objective: The objective of this study was conducted to evaluate clinically and radiographically the effectiveness of acemannan as direct pulp capping material in young permanent teeth. Subjects and Methods: The present study was performed on thirty six mandibular first young permanent molars with deep carious lesion indicated for direct pulp capping. The children aged from six to nine years old. After completely removing the infected dentine, teeth with a pinpoint pulpal exposure were randomly divided into two treatment groups: (group A) Acemannan or (group B) calcium hydroxide paste. In both groups, the remaining part of the cavity was filled with resin-modified glass ionomer filling. The teeth were assessed clinically and radiographically at different intervals (48 hours, 1.5 month and 3 months post-operative). Results: The present study revealed that, the clinical and radiographic success rate of acemannan was (77.8%), while Calcium hydroxide group showed a higher success rate (83.3%). Conclusion: Although the acemannan is a promising material but calcium hydroxide offers good clinical and radiographic results and success than acemannan but with no statistically significant differences.

Potential Combination of Acemannan Sponge and Calcium Phosphate Cement-Calcium Sulfate Hemihydrate (CPC-CSH) as Direct Pulp Capping Alternative Materials for Reparative Dentin Formation

“…In a study by Elhag et al, acemannan as a material for direct pup capping the success rate on mandibular permanent first molars with carious lesions was 77.8%, while in human primary teeth it was 72.73% after 6 months of observation. When applied as a DPC agent, acemannan material will induce the growth of dental pulp cells to stimulate dental pulp cells differentiation into growth factor synthesis and osteoblast-like cells of the extracellular matrix, as well as the formation of new dentin and mineral deposition, according to Elhag et al 28 in vitro studies. 28 Gonna et al evaluated the histological impacts of acemannan and formocresol as a material for pulp-dressing treatment in primary teeth undergoing pulpotomy treatment.…”

“…When applied as a DPC agent, acemannan material will induce the growth of dental pulp cells to stimulate dental pulp cells differentiation into growth factor synthesis and osteoblast-like cells of the extracellular matrix, as well as the formation of new dentin and mineral deposition, according to Elhag et al 28 in vitro studies. 28 Gonna et al evaluated the histological impacts of acemannan and formocresol as a material for pulp-dressing treatment in primary teeth undergoing pulpotomy treatment. The acemannan and formocresol groups had effectiveness of 75 and 25%.…”

“…27 Acemannan has good immunomodulating and antimicrobial properties as well as cytocompatibility and biocompatibility with various cell types. 28 In vivo tests have shown that acemannan accelerates the formation of reparative dentin and oral wound healing. In addition, in vivo tests showed acemannan as a wound healing agent caused increased bone mineral density and faster wound healing compared with wounds that were not treated with acemannan.…”