Clinical and radiographic disease course of hand osteoarthritis and determinants of outcome after 6 years

Bijsterbosch, J.; Watt, Iain; Meulenbelt, Ingrid; Rosendaal, Frits R.; Huizinga, T.W.J.; Kloppenburg, Margreet

doi:10.1136/ard.2010.133017

Cited by 79 publications

(84 citation statements)

References 23 publications

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“…In later stages, acromegalic arthropathy was thought to act via one final common pathway with primary OA (1, 22, 23, 24), indicating the same factors to be involved in progression. In accordance, we demonstrated that common risk factors for primary OA development, such as higher age, apply for patients with long-term controlled acromegaly (1,25,26,27,28). However, several parameters reflecting GH/IGF1 activity appeared to influence the progression of acromegalic arthropathy in the present study.…”

Section: Discussionsupporting

confidence: 86%

Progression of acromegalic arthropathy despite long-term biochemical control: a prospective, radiological study

Claessen

Ramautar

Pereira

et al. 2012

European Journal of Endocrinology

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Objective: Arthropathy is an invalidating complication of acromegaly, of which the prognosis and determinants are currently unknown in treated acromegaly. Therefore, the objective of the present study was to investigate the radiographic progression of arthropathy over a mean follow-up period of 2.6 years and determinants of outcome in patients with long-term, well-controlled acromegaly. Design: Prospective follow-up study. Methods: In a prospective cohort study we studied 58 patients (mean age 62, women 41%) with controlled acromegaly for a mean of 17.6 years. Radiographic progression of joint disease was defined by the Osteoarthritis Research Society International classification as a 1-point increase in joint space narrowing (JSN) or osteophyte scores on radiographs of the hands, knees, and hips obtained at the first study visit and after 2.6 years. Potential risk factors for progression were assessed. Results: Progression of osteophytes and JSN was observed in 72 and 74% of patients respectively. Higher age predisposed for osteophyte progression. Patients with biochemical control by somatostatin (SMS) analogs had more progression of osteophytosis than surgically cured patients (odds ratioZ18.9, PZ0.025), independent of age, sex, BMI, baseline IGF1 SDS and exon 3 deletion of the GHR. This was also evident for JSN progression, as were higher age and higher baseline IGF1 SDS. Conclusions: Acromegalic patients have progressive JSN and osteophytosis, despite long-term biochemical control. Parameters reflecting GH/IGF1 activity were associated with progressive joint disease. Remarkably, biochemical control by SMS analogs was associated with more progression than surgical cure. Although the present study is not a randomized controlled trial, this may indicate insufficient GH control according to current criteria and the need for more aggressive therapy.

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Section: Discussionsupporting

confidence: 86%

Progression of acromegalic arthropathy despite long-term biochemical control: a prospective, radiological study

Claessen

Ramautar

Pereira

et al. 2012

European Journal of Endocrinology

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“…Consent was not given by 43 (12%) patients, 12 (3.3%) were deceased and 2 (0.6%) were lost to follow-up. Reasons for non-consent are listed elsewhere 2. Of the 242 eligible patients, 236 had complete radiographic data and were included in the present study.…”

Section: Resultsmentioning

confidence: 99%

Clustering of hand osteoarthritis progression and its relationship to progression of osteoarthritis at the knee

et al. 2013

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“…Osteoarthritis (OA) is a common joint disease characterized by progressive deterioration of the entire joint (1). Although OA has traditionally been regarded as a noninflammatory arthritis, recent studies have suggested that systemic inflammation is involved in its pathogenesis (2,3), albeit at much lower levels than in the recognized inflammatory arthropathies.…”

Section: Introductionmentioning

confidence: 99%

Cross‐Sectional and Longitudinal Associations Between Serum Levels of High‐Sensitivity C‐Reactive Protein, Knee Bone Marrow Lesions, and Knee Pain in Patients With Knee Osteoarthritis

Zhu

Jin

Wang

et al. 2016

Arthritis Care & Research

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Objective. To describe associations between serum high-sensitivity C-reactive protein (hsCRP), knee bone marrow lesions (BMLs), and knee pain, cross-sectionally and longitudinally, in patients with knee osteoarthritis (OA). Methods. Patients (n 5 192) with symptomatic knee OA (mean age 63 years, range 50-79, women 53%) were assessed at baseline and after 24 months. Serum hsCRP was measured using enzyme-linked immunosorbent assay. Knee BMLs were scored using the modified Whole-Organ Magnetic Resonance Imaging (MRI) Score from T2-weighted fat-supressed fast spin-echo MRI. Knee pain was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index. Results. Quartiles of baseline serum hsCRP were associated with the presence of knee BMLs (prevalence ratio 1.07 per quartile [95% confidence interval (95% CI) 1.00, 1.15]) and total knee pain scores (b 13.66 per quartile [95% CI 2.26, 25.07]) in multivariable analyses. Longitudinally, higher baseline hsCRP was associated with an increase in BML score (risk ratio 1.37 per quartile [95% CI 1.10, 1.70]), and change in hsCRP was positively associated with change in BML score (b 0.19 [95% CI 0.05, 0.34]) in adjusted analyses. Baseline hsCRP was not associated with change in total knee pain, but change in hsCRP was positively and significantly associated with change in total knee pain (b 4.71 [95% CI 0.48, 8.94]). This became nonsignificant after adjustment for changes in BML score. Conclusion. In patients with knee OA, serum hsCRP is associated with knee BML scores and, to a lesser extent, pain both cross-sectionally and longitudinally, suggesting that inflammation is linked with BMLs and their associated pain.

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Clinical and radiographic disease course of hand osteoarthritis and determinants of outcome after 6 years

Abstract: This study gives insight in the clinical and radiographic course of hand OA as well as determinants of outcome. These findings enable better patient information on prognosis. The relationship between clinical and radiographic outcome needs further investigation.

Cited by 79 publications

References 23 publications

Progression of acromegalic arthropathy despite long-term biochemical control: a prospective, radiological study

Progression of acromegalic arthropathy despite long-term biochemical control: a prospective, radiological study

Clustering of hand osteoarthritis progression and its relationship to progression of osteoarthritis at the knee

Cross‐Sectional and Longitudinal Associations Between Serum Levels of High‐Sensitivity C‐Reactive Protein, Knee Bone Marrow Lesions, and Knee Pain in Patients With Knee Osteoarthritis

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