Clinical and Prognostic Value of Serum Neutrophil Gelatinase-Associated Lipocalin in Patients With ST-Segment Elevation Myocardial Infarction

Зыков, М. В.; Кашталап, В. В.; Быкова, И. С.; Hryachkova, O. N.; Kalaeva, V V; Shafranskaya, Kristina S.; Каретникова, В Н; Barbarash, O. L.

doi:10.18565/cardio.2016.5.24-29

Cited by 8 publications

(7 citation statements)

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“…Moreover, NGAL levels correlated with established cardiovascular scores like the global registry of acute coronary events (GRACE) risk score and showed a positive association with the synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score [ 9 ]. In addition, NGAL seems to be a predictor of all-cause mortality in ST segment elevation myocardial infarction (STEMI) patients and positively correlates with the severity of coronary heart disease [ 10 , 11 ]. Interestingly, in a Danish registry, the measurement of NGAL in addition to other biomarkers and cardiovascular risk factors did not add any predictive value in a high risk population with stable coronary heart disease [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

NGAL Correlates with Femoral and Carotid Plaque Volume Assessed by Sonographic 3D Plaque Volumetry

Schreinlechner

Noflatscher

Lener

et al. 2020

JCM

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Background/Objectives: Inflammation represents a cornerstone in the development of atherosclerosis and early detection is essential to avoid cardiovascular events. Biomarkers like interleukin-1 beta, interleukin-6, or high sensitivity CRP (hs-CRP) have been investigated intensively in this field. Since they have several limitations, additional biomarkers are needed for cardiovascular risk stratification. The acute phase protein, neutrophil gelatinase-associated lipocalin (NGAL), modulates inflammation and is elevated in cardiovascular disease (CVD). Moreover, it contributes to plaque destabilization. Methods: In this prospective, single-center study, we included 323 asymptomatic patients with at least one cardiovascular risk factor or established CVD. NGAL levels were measured in plasma samples using a commercially available ELISA. Carotid, femoral, and total atherosclerotic plaque volumes (PV) were measured using a 3D ultrasound system (Philips iU22). Patients were separated into a low (n = 243) and high (n = 80) total PV group. Results: NGAL was significantly higher in patients with high total PV versus patients with low total PV. The NGAL amplitude for the prediction of high total PV was significantly higher when compared with hs-CRP. A high predictive value could also be observed for patients without established CVD. Conclusion: NGAL seems to be a promising biomarker for the identification of asymptomatic patients with atherosclerotic disease.

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Section: Introductionmentioning

confidence: 99%

NGAL Correlates with Femoral and Carotid Plaque Volume Assessed by Sonographic 3D Plaque Volumetry

Schreinlechner

Noflatscher

Lener

et al. 2020

JCM

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“…[15][16][17] A number of studies have also reported associations between elevated NGAL levels and poor outcomes (e.g., mortality, hospital readmissions, heart failure, major adverse cardiac events) in patients with pre-existing CVD or kidney disease. [18][19][20][21][22][23] The overall evidence suggests that NGAL may be involved in CVD development.…”

Section: Introductionmentioning

confidence: 99%

Plasma neutrophil gelatinase-associated lipocalin and risk of cardiovascular disease: Findings from the PREVEND prospective cohort study

Kunutsor¹,

Flores‐Guerrero

Kieneker

et al. 2018

Clinica Chimica Acta

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“…Multifocal atherosclerosis (MFA) and ST-segment 1.5-fold increase in IL-18 levels in patients with concomitant myocardial infarction recorded. [14] According to the literature, 40-60% of patients with acute myocardial infarction are obstructive vascular coronary artery damage and nonobstructive multi-vessel coronary artery damage in 8.8% of patients. [15] The diagnosis of recurrent myocardial infarction is usually very difficult.…”

Section: Resultsmentioning

confidence: 99%

Epidemiology, Risk Factors, Clinical Current, Diagnostics, Principles Of Treatment And Prevention Of Acute Myocardial Infarction In The Elderly And Old Population (Review)

Baxriddinovna

2020

TAJMSPR

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In view of the special medico-social importance of cardiovascular diseases, their prevention is one of the most important tasks facing medical science and the health care system. Ischemic heart disease and its most serious complication, acute myocardial infarction, is the main and most dangerous disease of the cardiovascular system. Epidemiological studies and screening measures for the prevention of cardiovascular diseases contain scientific data that can not only reduce the incidence, but, undoubtedly, prolong the life of the elderly and senile population.

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Clinical and Prognostic Value of Serum Neutrophil Gelatinase-Associated Lipocalin in Patients With ST-Segment Elevation Myocardial Infarction

Cited by 8 publications

References 0 publications

NGAL Correlates with Femoral and Carotid Plaque Volume Assessed by Sonographic 3D Plaque Volumetry

NGAL Correlates with Femoral and Carotid Plaque Volume Assessed by Sonographic 3D Plaque Volumetry

Plasma neutrophil gelatinase-associated lipocalin and risk of cardiovascular disease: Findings from the PREVEND prospective cohort study

Epidemiology, Risk Factors, Clinical Current, Diagnostics, Principles Of Treatment And Prevention Of Acute Myocardial Infarction In The Elderly And Old Population (Review)

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