Clinical and prognostic role of detection timing of distant metastases in patients with differentiated thyroid cancer

Abstract

In DTC with DM, loss of RAI uptake has an important role in survival. No significant difference in survival outcome was discovered between SDM and MDM; but, among SDM, pre-RAIT had significant shorter DSS than baseline-RAIT.

What Should We Prefer in the Surgical Management of Differentiated Thyroid Carcinomas?

“…However, the development of nodal metastases in the neck in two of our patients indicated that more radical interventions such as MRBD could not be ignored in the presence of clinically palpable neck nodes without histological evidence in differentiated thyroid carcinomas. It was reported that nodal involvement was an independent variable for disease recurrence and survival especially in follicular tumours and negatively affected the prognosis (32,33). While both patients who subsequently developed nodal metastases had follicular histology despite central compartment cleaning, these two patients underwent completion MRBD following the literature experiences.…”

“…The reason for secondary neck exploration in both patients could be inadequate nodal sampling in the first operation and could also be considered as the subsequent development of existing micro-metastases as a result of the decreased immune response. It was reported that the presence of micrometastatic disease (occult nodal metastasis) in the neck reached up to 80% after prophylactic neck dissections performed in the past (31,32). However, the incidence of recurrent disease was found to be low (13.5%) after a 10-year follow-up without performing lymph node dissection (31,32).…”

“…It was reported that the presence of micrometastatic disease (occult nodal metastasis) in the neck reached up to 80% after prophylactic neck dissections performed in the past (31,32). However, the incidence of recurrent disease was found to be low (13.5%) after a 10-year follow-up without performing lymph node dissection (31,32). Later, it was understood that the clinical significance in nodal involvement was observed in 7-8% of patients with differentiated thyroid carcinoma, and the tendency to more conservative interventions increased.…”

“…The studies demonstrated that 92% of local control could be achieved in the neck by limited neck dissection (berry picking, etc.) in well-differentiated carcinomas with minimal nodal involvement (32). Probably, development stops and even regresses in such metastases along with the removal of the primary tumour.…”

TRIM29 inhibits miR-873-5P biogenesis via CYTOR to upregulate fibronectin 1 and promotes invasion of papillary thyroid cancer cells

“…Although PTC patients have an excellent prognosis, lymph node metastasis (LNM) is common, even approximately up to 30-80% 39 . Lateral lymph node metastasis (LLNM), local invasion, and distant metastasis could increase the risk of locoregional recurrence and decrease the survival 12,40 . A large part of thyroid cancers are <1 cm in size, which be defined as papillary thyroid microcarcinoma (PTMC) 3 .…”