Clinical and prognostic reports from 270 patients with multiple primary melanomas: a 34‐year single‐institution study

Savoia, Paola; Osella‐Abate, Simona; Deboli, Tommaso; Marenco, Federica; Stroppiana, Elena; Novelli, Mauro; Fierro, Maria Teresa; Bernengo, M. G.

doi:10.1111/j.1468-3083.2011.04181.x

Cited by 34 publications

(74 citation statements)

References 23 publications

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“…In this study, we examined the relationship between MPM and SPC. The incidence of MPM in our population was 4%, which is consistent with the literature 3–5 . We found a female preponderance among patients with MPM, but a male preponderance among patients with MPM plus SPC.…”

Section: Discussionsupporting

confidence: 92%

“…Consequently, the risk of subsequent cancer is an important issue for patients with melanoma. In particular, there is a high risk of second primary melanoma, with an incidence of 1–8% 3–5 . Development of a second primary cancer (SPC) after a single primary melanoma (SPM) has been discussed in several studies, with a reported incidence of 1.5–20%.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, there is a high risk of second primary melanoma, with an incidence of 1-8%. [3][4][5] Development of a second primary cancer (SPC) after a single primary melanoma (SPM) has been discussed in several studies, with a reported incidence of 1.5-20%. The most common malignancies associated with SPM are nonmelanoma skin cancer (NMSC), breast cancer, malignant lymphomas and kidney neoplasms.…”

Section: Introductionmentioning

confidence: 99%

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Association between multiple cutaneous melanoma and other primary neoplasms

Manganoni¹,

Pavoni²,

Farisoglio³

et al. 2012

Clinical and Experimental Dermatology

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association between multiple cutaneous melanoma and other primary neoplasms

Manganoni¹,

Pavoni²,

Farisoglio³

et al. 2012

Clinical and Experimental Dermatology

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“…Multiple primary melanomas (MPM) are diagnosed in 1.2% to 8.2% of patients with sporadic melanoma . Patients with melanoma are at approximately nine‐fold increased risk of developing an additional primary melanoma compared to the general population . The risk is higher within the first year but remains elevated for more than 20 years after first diagnosis supporting a continued long‐term surveillance in melanoma patients …”

Section: Introductionmentioning

confidence: 99%

Dermoscopic similarity is an independent predictor of BRAF mutational concordance in multiple melanomas

Moscarella

Pellegrini

Pampena

et al. 2019

Experimental Dermatology

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Background The association of clinical and dermoscopic features with BRAF mutational status has been poorly analysed in multiple primary melanomas (MPM). Objective To investigate whether concordance of BRAF mutational status is associated with dermoscopic similarity in multiple melanomas of the same patient. Methods Dermoscopic images and corresponding tissue sections of 124 melanomas from 62 patients with MPM were selected at four Italian Dermatology Departments. Similarity of dermoscopic appearance between multiple melanomas was evaluated according to the presence of the same prevalent dermoscopic feature. The BRAFV600 mutational status was analysed with allele‐specific TaqManTM assays or pyrosequencing. Spearman's correlation and univariate and multivariate regression analysis were used for statistical analysis. Results A similar dermoscopic appearance was identified in 38.7% (24/62) of patients with MPM and was correlated with older age at first diagnosis (rho: 0.26; P: 0.042) and occurrence on sun‐damaged skin (rho: 0.27; P: 0.037). The BRAFV600 mutation was detected in 39.5% (49/124) of the tumors and a concordant BRAF mutational status between melanomas in 33/62 (53.2%) MPM patients. Dermoscopically similar melanomas showed 5.7‐fold higher odds to be concordant for BRAF mutational status compared to dissimilar lesions (OR: 5.7; 95% CI 1.7‐19.5; P: 0.005). Conclusion Dermoscopic similarity of multiple melanomas represents an independent clinical predictor of a concordant BRAF mutational status in MPM patients.

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“…Sunburn and intermittent sun exposure are the dominant environmental determinants of CMM risk, instead of large cumulative exposures of temperate climes (6,7). In addition to its increasing occurrence (3,(8)(9)(10) CMM patients seems to be at a greater risk of developing a second primary melanoma, non-melanoma skin cancers (NMSC), and primary noncutaneous malignancies compared with the general population (11)(12)(13)(14)(15)(16)(17)(18)(19). The aim of this study was to analyze the clinical features of patients with CMM in our area, characterized by a high proportion of European immigrant descendants.…”

Section: Introductionmentioning

confidence: 99%

A follow-up study of cutaneous melanoma cases and controls in Rosario, Argentina

Dagatti¹

2014

cderm

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SummaryIn recent years, cutaneous melanoma (CMM) incidence rates have increased in fair-skinned populations generating a growing demand for healthcare service. The aim of this study was to analyze the clinical characteristics of patients with CMM in our area -with a high proportion of European immigrant descendants -and to follow them up for assessing the development of new skin lesions, and primary noncutaneous cancers. Age at diagnosis, gender, sociodemographic and phenotypic characteristics, family history, anatomical location, thickness and histopathological characteristics of CMM and subsequent lesions occurring during a follow-up for at least 5 years were recorded. Clinical and pathological data were recorded at the time of diagnosis, with follow-up information being gathered in 65 cases and 65 controls. Subsequent non-cutaneous primary malignancies were seen in 10 cases (15.4%) and 3 controls (4.6%, p=0.041). A comprehensive follow-up together with a close dermatological monitoring through clinical and dermoscopically skin observation in patients with CMM are recommended not only to early detect new melanomas, but also to identify other skin neoplasm and internal malignancies.

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Clinical and prognostic reports from 270 patients with multiple primary melanomas: a 34‐year single‐institution study

Abstract: Skin examination and long-term follow-up are mandatory for patients affected by melanoma, with the intent to promptly diagnose not only a disease progression but also possible new primary melanomas.

Cited by 34 publications

References 23 publications

Association between multiple cutaneous melanoma and other primary neoplasms

Association between multiple cutaneous melanoma and other primary neoplasms

Dermoscopic similarity is an independent predictor of BRAF mutational concordance in multiple melanomas

A follow-up study of cutaneous melanoma cases and controls in Rosario, Argentina

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