Clinical and prognostic differences in fulminant hepatitis type A, B and non-A non-B.

Gimson, A.; White, Y S; Eddleston, A. L. W. F.; Williams, Roger

doi:10.1136/gut.24.12.1194

Cited by 108 publications

(32 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…14 In other series, it was the diagnosis in 26 of 31 children with fulminant hepatitis 15 and in 32 of 73 young adults with fulminant viral hepatitis. 16 Its mortality rate is the highest among the rates for all causes of acute liver failure, which accounts for its frequency among patients referred to our centers for transplantation.…”

Section: Discussionmentioning

confidence: 99%

Aplastic Anemia Complicating Orthotopic Liver Transplantation for Non-A, Non-B Hepatitis

et al. 1988

View full text Add to dashboard Cite

Aplastic anemia developed in 9 of 32 patients (28 percent) undergoing orthotopic liver transplantation for acute non-A, non-B hepatitis, at one to seven weeks after the procedure. No patient previously had evidence of hematologic dysfunction or conditions known to be associated with aplastic anemia. No other cases of aplastic anemia were identified among 1463 patients undergoing liver transplantation for all other indications at the four centers participating in the study (chi-square = 415, P<0.001; 95 percent confidence interval for the incidence of aplastic anemia after transplantation for non-A, non-B hepatitis, 13 to 44 percent, vs. 0.00 to 0.13 percent for all other indications).The operative and postoperative treatment of these patients was not otherwise different, indicating that the aplastic anemia was a complication of the hepatitis, not of the transplantation procedure. Four of the nine patients died of complications due to infections. Three of the surviving patients have been followed for less than six months, one for one year, and one for two years. The two patients followed the longest have recovered marrow function to an appreciable degree, and two of the others have evidence of early recovery.We conclude that patients undergoing orthotopic liver transplantation for non-A, non-B hepatitis are at a high risk for the development of aplastic anemia.Liver failure after severe acute or subacute hepatitis is an accepted indication for orthotopic liver transplantation. A recent analysis of 29 patients with acute liver failure demonstrated that the odds in favor of survival were greatly increased by transplantation, and the causes of treatment failure did not appear to be different from those in patients who underwent transplantation for other reasons. [1][2][3] We present clinical data on nine patients who had aplastic anemia after transplantation, a complication that may be unique to patients with acute non-A, non-B viral hepatitis.

show abstract

Section: Discussionmentioning

confidence: 99%

Aplastic Anemia Complicating Orthotopic Liver Transplantation for Non-A, Non-B Hepatitis

et al. 1988

View full text Add to dashboard Cite

show abstract

“…It may also be partially related to our finding that the fulminant form occurred most frequently among the NANB-AVH cases. A similar preponderance has been reported from many Western countries [1,3,4].…”

Section: Discussionmentioning

confidence: 52%

“…It has also helped in the study of the differences in the clinical picture among these different etiological categories, especially in relation to presentation, pregnancy, and prognosis. There have been few reports on this subject in general [1][2][3][4] and none from Iraq.…”

mentioning

confidence: 99%

Etiology and Clinical Pattern of Fulminant Hepatitis in Iraq

Rassam¹,

Goudeau

Dubois

et al. 1991

Ann Saudi Med

View full text Add to dashboard Cite

Of 253 prospectively studied cases of acute viral hepatitis (AVH), 47 were fulminant (18.6%). There were 15 males and 32 females. Their age ranged from 7 to 60 years (mean, 28 years). Serological evidence of AVH-A was found in one case (2%), AVH-B in 13 cases (28%), AVH-D in one case (2%), and AVH-NANB in 32 cases (68%). Fulminant hepatitis was found in 2.6% of AVH-A cases, in 16.25% of AVH-B cases, in one of two AVH-D superinfections, and in 24.8% of the AVH-non-A, non-B (NANB) cases. The clinical picture in the two main etiological categories, namely the AVH-B and the AVH-NANB, showed that the latter possessed a more prolonged and severe clinical course with higher mortality (P <0.001). It also showed a higher mortality in females of the child bearing age, compared with males of the same age group (P <0.001).

show abstract

“…Viral hepatitis non-A, non-B, unlike viral hepatitis A and some waterborne diseases, is not benign and high mortality rates have been recorded in patients with epidemic viral hepatitis non-A, non-B (11,16), subacute hepatitis (3), and fulminant hepatitis (17,18).…”

Section: Methodsmentioning

confidence: 99%

Hepatitis virus non-A, non-B: The cause of a major public health problem in India

1986

Indian J Pediatr

View full text Add to dashboard Cite

Serological studies of hepatitis viruses A and B were carried out on 362 patients with acute viral hepatitis, 130 with fulminant hepatitis, and 56 with subacute hepatitis, and on samples ofserumfrom 230 subjects during epidemics ofviral hepatitis. A diagnosis ofnon-A, non-B viral hepatitis was made when serological tests showed that anti-HA V IgM and anti-HBc IgM were absent. Hepatitis virus non-A, non-B was the causative agent responsiblefor 58% of cases with acute viral hepatitis, 58%o with fulminant hepatitis, 87%with subacute hepatitis, and 66% with epidemic hepatitis. A considerable proportion of patients (6-32%) were infected with both hepatitis virus non-A, non-B and hepatitis virus B. Viral hepatitis non-A, non-B is probably transmitted by infection ofdrinking-water and is the principal cause of hepatitis in India.Hepatitis virus A, hepatitis virus B, hepatitis virus non-A, non-B, and delta agent are the four important primary etiological agents of viral hepatitis. Hepatitis virus non-A, non-B consists of two distinct groups of viruses, one of which is responsible for posttransfusion hepatitis, and the other for a waterborne, faecal/oral infection. Hepatitis virus A causes a relatively benign disease and does not constitute a major public health problem.In contrast, hepatitis virus B is responsible for severe liver damage and is associated with chronic liver diseases, cirrhosis of the liver, and hepatocellular carcinoma. The disease is one of the most serious public health problems in the world. Spread of hepatitis virus B can be controlled by using disposable needles and syringes, by more scrupulous sterilization of surgical instruments and appliances, and by immunization with hepatitis B immunoglobulin and/or hepatitis B vaccine.Hepatitis virus non-A, non-B, has now emerged as a major cause of hepatitis. Some countries have reported waterborne viral hepatitis non-A, non-B, and in India, where the supply of safe drinking-water is difficult, the disease poses an enormous health problem.

show abstract

Clinical and prognostic differences in fulminant hepatitis type A, B and non-A non-B.

Cited by 108 publications

References 6 publications

Aplastic Anemia Complicating Orthotopic Liver Transplantation for Non-A, Non-B Hepatitis

Aplastic Anemia Complicating Orthotopic Liver Transplantation for Non-A, Non-B Hepatitis

Etiology and Clinical Pattern of Fulminant Hepatitis in Iraq

Hepatitis virus non-A, non-B: The cause of a major public health problem in India

Contact Info

Product

Resources

About