Clinical and Prognostic Characteristics of Recurrent Intracerebral Hemorrhage: A Contrast to First-Ever ICH

Wan, Yan; Guo, Hongxiu; Bi, Rentang; Chen, Shaoli; Shen, Jing; Li, Man; Xia, Yuanpeng; Zhang, Lei; Sun, Zhou; Chen, Xiaolu; Cai, Zhuoyuan; Wang, Zhaowei; Gong, Daokai; Xu, Jingwen; Zhu, Dongya; Hu, Bo; He, Quanwei

doi:10.3389/fnagi.2022.860571

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…Compared with previous studies, we found that the incidence of pulmonary disease (80.6% vs. 11.1%) and cerebrovascular disease (62.5% vs. 23.5%) was particularly high in the elderly population. In addition, pulmonary [18][19][20] and cerebrovascular [21,22] diseases have been proven to play an important role in the prognosis of ICH patients. A previous study focused on functional outcome after 1 year of ICH [12], and our study demonstrates that CCI, as a sum score weighted according to the presence of various comorbidities, also has an impact on the short-term prognosis of elderly ICH patients.…”

Section: Discussionmentioning

confidence: 99%

The prognostic value of the Charlson comorbidity index in aged patients with intracerebral hemorrhage

et al. 2022

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Background Comorbidities are common in aged intracerebral hemorrhage patients. The purpose of this study was to assess whether the Charlson Comorbidity Index (CCI) was associated with in-hospital death and short-term functional outcome in elderly patients (age ≥ 70) with intracerebral hemorrhage (ICH). Methods This was a retrospective cohort of aged ICH patients (≥70 years old) admitted within 24 hours of ICH onset. The CCI was derived using hospital discharge ICD-9 CM codes and patient history obtained from standardized case report forms. Multivariable logistic regression was used to determine the independent effect of the CCI score on clinical outcomes. Results In this cohort of 248 aged ICH patients, comorbid conditions were common, with CCI scores ranging from 2 to 12. Logistic regression showed that the CCI score was independently predictive of 1-month functional outcome (OR = 1.642, P < 0.001) and in-hospital death (OR = 1.480, P = 0.003). Neither ICH volume nor the presence of IVH was an independent predictive factor for 1-month functional outcome or in-hospital mortality (P < 0.05). Conclusion Comorbid medical conditions as assessed by the CCI independently influence short-term outcomes in aged ICH patients. The characteristics of the hematoma itself, such as ICH volume and the presence of IVH, seem to have a reduced effect on it.

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Section: Discussionmentioning

confidence: 99%

The prognostic value of the Charlson comorbidity index in aged patients with intracerebral hemorrhage

et al. 2022

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“…Disease severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) score and the Glasgow Coma Scale (GCS) score. 26 , 27 Plasma C3 levels were quantitatively measured with a Coulter reagent according to the manufacturer's instructions on the Beckman Coulter AU5800 clinical chemistry analyzer (Beckman Coulter Inc., California, USA). The test was performed and analyzed by the same technician.…”

Section: Methodsmentioning

confidence: 99%

Normobaric hyperoxia alleviates complement C3‐mediated synaptic pruning and brain injury after intracerebral hemorrhage

Wu,

Chen,

Zhao

et al. 2024

CNS Neurosci Ther

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BackgroundIntracerebral hemorrhage (ICH) is a common cerebrovascular disease, and the complement cascade exacerbates brain injury after ICH. As the most abundant component of the complement system, complement component 3 (C3) plays essential roles in all three complement pathways. However, the effects of C3 on neurological impairment and brain injury in ICH patients and the related mechanism have not been fully elucidated. Normobaric hyperoxia (NBO) is regarded as a treatment for ICH patients, and recent clinical studies also have confirmed the neuroprotective role of NBO against acute ICH‐mediated brain damage, but the underlying mechanism still remains elusive.AimsIn the present study, we investigated the effects of complement C3 on NBO‐treated ICH patients and model mice, and the underlying mechanism of NBO therapy in ICH‐mediated brain injury.ResultsHemorrhagic injury resulted in the high plasma C3 levels in ICH patients, and the plasma C3 levels were closely related to hemorrhagic severity and clinical outcomes after ICH. BO treatment alleviated neurologic impairments and rescued the hemorrhagic‐induced increase in plasma C3 levels in ICH patients and model mice. Moreover, the results indicated that NBO exerted its protective effects of on brain injury after ICH by downregulating the expression of C3 in microglia and alleviating microglia‐mediated synaptic pruning.ConclusionsOur results revealed that NBO exerts its neuroprotective effects by reducing C3‐mediated synaptic pruning, which suggested that NBO therapy could be used for the clinical treatment of ICH.

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“…The disease severity was assessed utilizing the National Institutes of Health Stroke Scale (NIHSS) score and the Glasgow Coma Scale (GCS) score by trained neurologists at admission ( Currò et al, 2022 ; Wan et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

High plasma complement C4 levels as a novel predictor of clinical outcome in intracerebral hemorrhage

Chen

Jiang³

et al. 2023

Front. Aging Neurosci.

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ObjectiveThe complement cascade is activated and contributes to the brain injury after intracerebral hemorrhage (ICH). Complement component 4 (C4), an important component of complement cascade, has been associated with severity of neurological impairment that occurs during ICH. However, the correlation of plasma complement C4 levels with hemorrhagic severity and clinical outcome in ICH patients has not been reported.Materials and methodsThis study is a monocentric, real-world, cohort study. In this study, we measured the plasma complement C4 levels of 83 ICH patients and 78 healthy controls. The hematoma volume, the National Institutes of Health Stroke Scale (NIHSS) score, the Glasgow Coma Scale (GCS) score, and the permeability surface (PS) were used to assess and quantify neurological deficit following ICH. Logistic regression analysis was configured to determine the independent relation of plasma complement C4 levels to hemorrhagic severity and clinical outcomes. The contribution of complement C4 to secondary brain injury (SBI) was assessed by changes in plasma C4 levels between admission and at day 7 after ICH.ResultsThere was a significant elevation of plasma complement C4 levels in ICH patients than in healthy controls (40.48 ± 1.07 vs. 35.25 ± 0.60, p < 0.0001), and the plasma complement C4 levels were closely related to the hemorrhagic severity. Moreover, plasma complement C4 levels of patients were positively correlated with the hematoma volume (r = 0.501, p < 0.001), NIHSS score (r = 0.362, p < 0.001), the GCS score (r = −0.490, p < 0.001), and PS (r = 0.683, p = 0.045) following ICH. Logistic regression analysis also confirmed that patients with high plasma complement C4 levels show a poor clinical outcome after ICH (p < 0.001). Meanwhile, the elevated plasma levels at day 7 after ICH indicated the correlation of complement C4 with SBI (p < 0.01).ConclusionPlasma complement C4 levels are significantly elevated in ICH patients and positively correlated with the illness severity. Thus, these findings highlight the importance of complement C4 in brain injury after ICH and provide a novel predictor of clinical outcome for this disease.

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Clinical and Prognostic Characteristics of Recurrent Intracerebral Hemorrhage: A Contrast to First-Ever ICH

Cited by 4 publications

References 25 publications

The prognostic value of the Charlson comorbidity index in aged patients with intracerebral hemorrhage

The prognostic value of the Charlson comorbidity index in aged patients with intracerebral hemorrhage

Normobaric hyperoxia alleviates complement C3‐mediated synaptic pruning and brain injury after intracerebral hemorrhage

High plasma complement C4 levels as a novel predictor of clinical outcome in intracerebral hemorrhage

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