Clinical and Preclinical Cognitive Function Improvement after Oral Treatment of a Botanical Composition Composed of Extracts from<i>Scutellaria baicalensis</i>and<i>Acacia catechu</i>

Yimam, Mesfin; Burnett, Bruce; Brownell, Lidia; Jia, Qi

doi:10.1155/2016/7240802

Cited by 10 publications

(8 citation statements)

References 49 publications

(53 reference statements)

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“…For example, total flavonoids from SB can protect neuronal damage and improve memory deficits induced by cerebral ischemia in rats (Shang et al, 2006; Cao et al, 2016). Additionally, a flavonoid composition (UP326) containing baicalin can help to maintain memorizing and processing abilities of aged animals (Yimam et al, 2016). As the major type of flavonoids in SB, baicalein and baicalin ameliorated cognitive impairment in AD animal models (Wei et al, 2014; Chen et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

The New Application of UHPLC-DAD-TOF/MS in Identification of Inhibitors on β-Amyloid Fibrillation From Scutellaria baicalensis

et al. 2019

Front. Pharmacol.

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Literary evidence depicts that aggregated β-amyloid (Aβ) leads to the pathogenesis of Alzheimer’s disease (AD). Although many traditional Chinese medicines (TCMs) are effective in treating neurodegenerative diseases, there is no effective way for identifying active compounds from their complicated chemical compositions. Instead of using a traditional herbal separation method with low efficiency, we herein apply UHPLC-DAD-TOF/MS for the accurate identification of the active compounds that inhibit the fibrillation of Aβ (1-42), via an evaluation of the peak area of individual chemical components in chromatogram, after incubation with an Aβ peptide. Using the neuroprotective herbal plant Scutellaria baicalensis (SB) as a study model, the inhibitory effect on Aβ by its individual compounds, were validated using the thioflavin-T (ThT) fluorescence assay, biolayer interferometry analysis, dot immunoblotting and native gel electrophoresis after UHPLC-DAD-TOF/MS analysis. The viability of cells after Aβ (1-42) incubation was further evaluated using both the tetrazolium dye (MTT) assay and flow cytometry analysis. Thirteen major chemical components in SB were identified by UHPLC-DAD-TOF/MS after incubation with Aβ (1–42). The peak areas of two components from SB, baicalein and baicalin, were significantly reduced after incubation with Aβ (1–42), compared to compounds alone, without incubation with Aβ (1–42). Consistently, both compounds inhibited the formation of Aβ (1–42) fibrils and increased the viability of cells after Aβ (1–42) incubation. Based on the hypothesis that active chemical components have to possess binding affinity to Aβ (1–42) to inhibit its fibrillation, a new application using UHPLC-DAD-TOF/MS for accurate identification of inhibitors from herbal plants on Aβ (1–42) fibrillation was developed.

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Section: Discussionmentioning

confidence: 99%

The New Application of UHPLC-DAD-TOF/MS in Identification of Inhibitors on β-Amyloid Fibrillation From Scutellaria baicalensis

et al. 2019

Front. Pharmacol.

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“…Based on toxicological and clinical studies, S. baicalensis, H. erinaceus and R. rosea are generally considered to be safe and well tolerated [40,[52][53][54][55][56][57][58][59][60][61][62][63]. In experimental studies, the estimated median lethal dose (LD 50 ) of some compounds varies according to the extraction method and administration route [54].…”

Section: S Baicalensis H Erinaceus and R Rosea: Toxicology And Nementioning

confidence: 99%

“…Baicalin was shown to inhibit the proliferation of embryonic stem cells at half maximal inhibitory concentration (IC 50 ) values up to 135.9 mgL, suggesting that it may induce low embryonic toxicity at high concentrations [56]. In humans, oral intake of S. baicalensis extracts and baicalin at the daily doses of 300 mg and 200-800 mg respectively, is generally safe and well tolerated [57,58].…”

Section: S Baicalensis H Erinaceus and R Rosea: Toxicology And Nementioning

confidence: 99%

“…In a human clinical trial, subjects who were orally given 300 mg of S. baicalensis extract (formulation UP326) for 30 days showed a marked improvement in speed and accuracy of processing complex information in computer tasks [58]. They also showed a reduced standard deviation of performance compared to baseline and the placebo group.…”

Section: S Baicalensis In Clinical Studiesmentioning

confidence: 99%

“…Safe and well tolerated. Marked improvement in speed and accuracy of processing complex information in computer tasks [58].…”

Section: Clinical Studies S Baicalensis H Erinaceus Rroseamentioning

confidence: 99%

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Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea

et al. 2020

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Recent studies focused on the pharmacology and feasibility of herbal compounds as a potential strategy to target a variety of human diseases ranging from metabolic to brain disorders. Accordingly, bioactive ingredients which are found within a variety of herbal compounds are reported to produce both neuroprotective and psychotropic activities which may help to combat mental disorders such as depression, anxiety, sleep disturbances and cognitive alterations. In the present manuscript, we focus on three herbs which appear effective in mitigating anxiety or depression with favourable risk-benefit profiles, namely Scutellaria baicalensis (S. baicalensis), Hericium erinaceus (H. erinaceus) and Rhodiola rosea (R. rosea). These three traditional folk medicinal herbs target the main biochemical events that are implicated in mental disorders, mimicking, to some extent, the mechanisms of action of conventional antidepressants and mood stabilizers with a wide margin of tolerability. In detail, they rescue alterations in neurotransmitter and neuro-endocrine systems, stimulate neurogenesis and the synthesis of neurotrophic factors, and they counteract oxidative stress, mitochondrial dysfunction and inflammation. Albeit the encouraging results that emerge from both experimental and clinical evidence, further studies are needed to confirm and better understand the mental-health promoting, and specifically, the antidepressant effects of these herbs.

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Acacia catechu (L.f.) Willd and Scutellaria baicalensis Georgi extracts suppress LPS‐induced pro‐inflammatory responses through NF‐кB, MAPK, and PI3K‐Akt signaling pathways in alveolar epithelial type II cells

Tian

Zhou

Gai

et al. 2019

Phytotherapy Research

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Acacia catechu (L.f.) Willd (ACW) and Scutellaria baicalensis Georgi (SBG) are one of the most famous couplet Chinese medicines, widely used for treating infantile cough, phlegm, and fever caused by pulmonary infection. However, the underlying molecular mechanism of their anti‐inflammatory activity has not been determined. The aim of this study was to evaluate the protective effect of this couplet Chinese medicines (ACW‐SBG) on lipopolysaccharide (LPS)‐induced inflammatory responses in acute lung injury (ALI) model of rats and the potential molecular mechanisms responsible for anti‐inflammatory activities in alveolar epithelial type II cells (AEC‐II). Standardization of the 70% ethanol extract of ACW and SBG was performed by using a validated reversed‐phase high‐pressure liquid chromatography method. Rats were pretreated with ACW‐SBG for 7 days prior to LPS challenge. We assessed the effects of ACW‐SBG on the LPS‐induced production of tumor necrosis factor alpha (TNF‐α) and interleukin 1 beta (IL‐1β) in the bronchoalveolar lavage fluid (BALF). The wet‐to‐dry weight ratio was calculated, and hematoxylin and eosin staining of lung tissue was performed. Cell viability of AEC‐II was measured by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay. Real‐time quantitative reverse transcription polymerase chain reaction assay was carried out to quantify the relative gene expression of TNF‐α and IL‐1β in AEC‐II. The western blotting analysis was executed to elucidate the expression of mediators linked to nuclear factor‐kappa B (NF‐κB), mitogen‐activated protein kinase (MAPK), and phosphatidylinositol‐3 kinase‐protein kinase B (PI3K‐Akt) signaling pathways. ACW‐SBG significantly decreased lung wet‐to‐dry weight ratio, ameliorated LPS‐induced lung histopathological changes, and reduced the release of inflammatory mediators such as TNF‐α and IL‐1β in BALF. In AEC‐II, we found that the expression of TNF‐α mRNA was also inhibited by ACW‐SBG. ACW‐SBG blocked NF‐κB activation by preventing the phosphorylation of NF‐κB (p65) as well as the phosphorylation and degradation of the inhibitor of kappa B kinase. ACW‐SBG extracts also inhibited the phosphorylation of respective MAPKs (c‐Jun N‐terminal kinase, extracellular signal‐regulated kinase, and p38) as well as Akt. The present study demonstrated that ACW‐SBG played a potent anti‐inflammatory role in LPS‐induced ALI in rats. The potential molecular mechanism was involved in attenuating the NF‐κB, MAPKs, and PI3K‐Akt signaling pathways in LPS‐induced AEC‐II.

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Clinical and Preclinical Cognitive Function Improvement after Oral Treatment of a Botanical Composition Composed of Extracts fromScutellaria baicalensisandAcacia catechu

Cited by 10 publications

References 49 publications

The New Application of UHPLC-DAD-TOF/MS in Identification of Inhibitors on β-Amyloid Fibrillation From Scutellaria baicalensis

The New Application of UHPLC-DAD-TOF/MS in Identification of Inhibitors on β-Amyloid Fibrillation From Scutellaria baicalensis

Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea

Acacia catechu (L.f.) Willd and Scutellaria baicalensis Georgi extracts suppress LPS‐induced pro‐inflammatory responses through NF‐кB, MAPK, and PI3K‐Akt signaling pathways in alveolar epithelial type II cells

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