Clinical and pathological study on mixed tumors of the skin

Wan, Huiying; Xu, Minyan; Xia, Tian

doi:10.1097/md.0000000000012216

Cited by 20 publications

(28 citation statements)

References 36 publications

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“…13 Furthermore, the degree of myoepithelial differentiation is lower in chondroid syringomas, expression of desmin and actin are almost negative which differentiate this tumor from PAs. 14 In our case, immunohistochemical examination showed positive CK19 and EMA phenotypes expression, which is characteristic of ductal component. Also, smooth muscle actin and CK7 expressed by myoepithelial cells was positive.…”

Section: Discussionsupporting

confidence: 54%

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Pleomorphic Adenoma of the Ala Nasi: A Case Report

Mouzali

Lameche

Slimani

et al. 2019

Clin Med Insights Ear Nose Throat

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Objectives: Pleomorphic adenomas are benign tumors that rarely involve nonsalivary glands. We report an uncommon case of ala nasi pleomorphic adenoma. We discuss the clinical and histopathologic characteristics, and review the literature on nasal pleomorphic adenoma. Method: A 20-year-old man presented with a painless slow growing lobulated mass located on the right ala nasi extending into the nasal vestibule. Results: Complete surgical excision was performed. Histologic examination found a mixed cellular component: epithelial and myoepithelial cells with chondromyxoid stroma. This was consistent with the diagnosis of a typical pleomorphic adenoma. There was no evidence of recurrence at 18 months after the surgery. Conclusions: Pleomorphic adenomas located in the external nose are extremely rare. In such case, pleomorphic adenoma could originate from ectopic minor salivary gland. Complete surgical excision with long-term follow-up is recommended due to the potential risk of recurrence and malignant transformation.

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Section: Discussionsupporting

confidence: 54%

“…Furthermore, the degree of myoepithelial differentiation is lower in chondroid syringomas, expression of desmin and actin are almost negative which differentiate this tumor from PAs. 14…”

Section: Discussionmentioning

confidence: 99%

Pleomorphic Adenoma of the Ala Nasi: A Case Report

Mouzali

Lameche

Slimani

et al. 2019

Clin Med Insights Ear Nose Throat

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“…However, the presence of minor salivary glands in the lower lip poses a challenging CS diagnostic problem. Cutaneous adnexal tumours, such as pleomorphic adenoma (PA) of the salivary gland exhibit similar clinical and histopathological features and may localise in the lower lip as well (27)(28)(29). Further, there is a strong possibility of a close molecular level relationship between CS and PA tumor types (30).…”

Section: Introductionmentioning

confidence: 99%

“…The inner component expression profile includes inter alia cytokeratins (CK), carcinoembryonic antigen (CEA) and epithelial membrane antigen (EMA). However, the outer and matrix expression profile includes vimentin, S100 protein, neuron-specific enolase, glial fibrillary acidic protein or different types of actin, such as the smooth muscle actin protein (SMA) ( 27 , 32 ).…”

Section: Introductionmentioning

confidence: 99%

Mixed tumour of the skin of the lower lip: A case report and review of the literature

et al. 2022

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Mixed tumour of the skin or chondroid syringoma (CS) is a rare and mostly benign neoplasm of the sweat glands. Although CS is frequently located on varied parts of the head and neck region, the lower lip is a rarely reported site. The present report describes a case of CS of the lower lip in a 58-year-old male as an expository case to further emphasise the need for proper diagnosis, appropriate treatment and prognostic evaluation. The patient presented with a round, non-tender, slightly hard and mobile mass beneath the mucocutaneous junction of his left lateral side of the lower lip. Radiology revealed a mass measuring 11x11x7 mm 3 in size at a depth of ~2 mm. Furthermore, magnetic resonance T1-and T2-weighted images showed slightly low and high signal intensities, respectively. A provisional diagnosis of benign tumour of the lower lip was made, and surgical excision biopsy taken under local anaesthesia, while considering the patient's cosmetic appearance. Histopathology demonstrated features akin to apocrine gland, chondroid and myxoid stroma consistent with the diagnosis of benign CS. No evidence of recurrence or satellites were recorded after a follow-up of nearly 2 years. Although rare, a high index of suspicion for CS among other cutaneous adnexal tumours of the lower lip is necessary. In addition, interprofessional collaboration in the management of such oral tumours could enhance patient satisfaction amid prevailing intraoral and aesthetic concerns.

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“…This is partly due to their rarity and broad biologic spectrum. [1][2][3][4] Correct classification is critical because the differential diagnosis includes highly malignant neoplasms and treatment varies significantly. Myxochondroid metaplasia of the plantar foot, which has been rarely reported in the English literature, enters this differential diagnosis because it usually presents in the dermis and superficial subcutis.…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Myxochondroid Metaplasia of the Plantar Foot With Review of Histopathological Mimics

Alomari

Warnock²,

Cummings³

2022

The American Journal of Dermatopathology

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:Chondromyxoid metaplasia can rarely lead to the formation of a distinctive tumor-like proliferation in the plantar foot. This is thought to represent a reactive or reparative process, possibly due to chronic trauma. For the unwary dermatopathologist, this could represent a diagnostic challenge. Herein, we review the clinical, histopathological, and molecular presentation of an athletic 17-year-old boy with a soft tissue mass arising in the right plantar foot. Microscopic examination showed a relatively circumscribed proliferation of spindle cells with abundant chondromyxoid stroma, hyalinization, and diffuse ERG reactivity. We also review characteristics of this entity that help differentiate it from clinical and histopathologic mimics and postulate possible links with soft tissue chondromas and immature chondroid choristoma.

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Clinical and pathological study on mixed tumors of the skin

Abstract: Supplemental Digital Content is available in the text

Cited by 20 publications

References 36 publications

Pleomorphic Adenoma of the Ala Nasi: A Case Report

Pleomorphic Adenoma of the Ala Nasi: A Case Report

Mixed tumour of the skin of the lower lip: A case report and review of the literature

A Rare Case of Myxochondroid Metaplasia of the Plantar Foot With Review of Histopathological Mimics

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