Clinical and pathological study of ischaemic neuropathy.

Eames, Rosemary A.; Lange, L. S.

doi:10.1136/jnnp.30.3.215

Cited by 124 publications

(37 citation statements)

References 33 publications

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“…Widespread arteritis associated with axonal degeneration of the nerve fibers, findings similar to those in the neuropathy of other forms of peripheral vascular disease, lends strong support to a vascular etiology for rheumatoid neuropathy (29). Autopsy studies (30, 31) have previously suggested such a relationship, and recently Weller et a1 (32), in biopsy studies of sural nerves in rheumatoid neuropathy, found occluded, thrombosed arteries associated with axonal degeneration.…”

Section: Sural Nerves In Rheumatoid Arthritismentioning

confidence: 72%

Immunopathologic Study of Sural Nerves in Rheumatoid Arthritis

Conn

McDuffie

Dyck

1972

Arthritis & Rheumatism

123

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Section: Sural Nerves In Rheumatoid Arthritismentioning

confidence: 72%

Immunopathologic Study of Sural Nerves in Rheumatoid Arthritis

Conn

McDuffie

Dyck

1972

Arthritis & Rheumatism

123

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“…Lachance & Daube, 1991), muscle compartment syndrome (e.g. Hargens, Romine, Sipe, Evans, Mubarak & Akeson, 1979) and a number of less common disorders (see Eames & Lange, 1967;Harriman, 1977). Despite the prevalence of nerve ischaemia pathologically, the existing scientific literature is unclear regarding the effect of ischaemia upon nerve conduction in fibres of different sizes and functions.…”

Section: Introductionmentioning

confidence: 99%

The relationship between ischaemic conduction failure and conduction velocity in cat myelinated axons

Fern

Harrison²

1994

Experimental Physiology

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SUMMARYUnitary action potentials have been recorded from cat spinal root filaments following electrical stimulation of hindlimb peripheral nerves. Potentials were monitored both before and during the ischaemia which follows the onset of cardiac arrest. The relationship between time to conduction failure (survival time) and initial conduction velocity was detennined for 164 nerve fibres. This revealed that during ischaemia, slow myelinated axons tend to fail before fast myelinated axons. The average survival time was 24 6 min (range 11-39 min). The results are discussed in terms of (i) the possible mechanisms underlying ischaemic conduction block,(ii) their clinical implications for the role of ischaemia in peripheral neuropathies, and (iii) using ischaemia as an experimental technique to produce a differential nerve block.

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“…Quantitative morphological studies have mostly been performed on nerve specimens removed from limbs after amputation because of gangrene or intractable pain. Both signs of demyelinization and axonal degeneration are seen [62, 97, 101, 102, 103, 104, 105, 106]. There is no agreement on selective vulnerability of a certain fiber size [62, 104, 105].…”

Section: Clinical Ischemic Neuropathymentioning

confidence: 99%

“…Patients with peripheral arterial disease can have neuropathic features. Percentages of neurological abnormalities vary in different published series between 37, 59 and 88% [95, 96, 97]. Complaints are predominantly sensory, whereas motor abnormalities are less frequent [95].…”

Section: Clinical Ischemic Neuropathymentioning

confidence: 99%