Clinical and pathological profile of skin melanoma in Dr. Sardjito Hospital Yogyakarta, Indonesia

Setiaji, Kunto; Rinonce, Hanggoro Tri; Azhar, Yohana; Wahyono, Artanto; Pasaribu, E.

doi:10.1016/j.ejso.2018.10.466

Cited by 3 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When compared to the previous studies for all melanoma subtypes in Asia, the prevalence of BRAF V600 mutation in this study was still lower than other Asian countries. Asian melanoma cases are dominated by the acral lentiginous subtype [4], while nodular melanoma was the most common subtype in Yogyakarta and Central Java, Indonesia [11]. This subtype pattern resembled two studies, in Mexico and Germany respectively, which also found nodular melanoma as the most common subtype [16, 17].…”

Section: Discussionmentioning

confidence: 75%

“…One study reported acral lentiginous melanoma as the most common subtype [10], while the Global Burden of Disease study found the superficial spreading subtype [4]. Yet a recent study reported nodular melanoma as the predominant subtype in Yogyakarta, Indonesia [11]. These contradictory results emphasize the lack of data on melanoma in Indonesia.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Low BRAF V600 mutation prevalence in primary skin nodular melanoma in Indonesia: a real-time PCR detection among Javanese patients

et al. 2019

View full text Add to dashboard Cite

BackgroundCutaneous melanoma is a rare, aggressive skin malignancy with a high mortality rate. Although only contributing 7.6% of the cases worldwide, Asia is responsible for 18.6% of deaths from cutaneous melanoma. BRAF V600 mutation presents a potential prognostic predictor in melanoma. Unfortunately, studies on that mutation in melanoma, particularly nodular subtype, in Indonesia are still scarce. This research aimed to investigate the prevalence of BRAF V600 mutation in primary skin nodular melanoma in Yogyakarta and Central Java, Indonesia. Its association with clinicopathological parameters was also analyzed.MethodsForty paraffin-embedded tissue samples from primary skin nodular melanoma cases in 2011–2018 were collected from the two biggest referral hospitals in Yogyakarta and Central Java, Indonesia. The BRAF V600 mutation status was assessed using qualitative real-time PCR and its associations with age, sex, anatomic location, lymph node metastasis, tumor thickness, ulceration, mitotic index, necrosis, lymphovascular invasion, and tumor-infiltrating lymphocytes were analyzed.ResultsBRAF V600 mutations were found in 4 (10%) samples. These mutations were significantly associated with the central (non-extremity) region (p = 0.013) and presence of lymphovascular invasion (p = 0.005). However, it was not associated with any other variables analyzed in this study.ConclusionThe prevalence of BRAF V600 mutation in Indonesian primary skin nodular melanoma cases is low and significantly associated with anatomic location and lymphovascular invasion. It is lower than prevalences in other Asian populations as well as in Caucasian populations and suggests that melanoma cases in Javanese people may have distinct clinicopathological characteristics from other Asian ethnicities.

show abstract

Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Low BRAF V600 mutation prevalence in primary skin nodular melanoma in Indonesia: a real-time PCR detection among Javanese patients

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Indonesian melanoma cases have distinct clinical features, showing different clinical presentations and histopathological subtypes from other Asian populations. As opposed to the acral lentiginous melanoma subtype predominance in Asia, most cases from Indonesia are of the nodular subtype, which is associated with worse prognosis [7]. The prevalence of BRAF V600 mutations in melanoma patients from Indonesia has also been shown to be relatively low.…”

Section: Introductionmentioning

confidence: 99%

BRAF V600 mutation profiling in primary skin nodular melanoma in Indonesia: an analysis using high resolution pyrosequencing

et al. 2020

View full text Add to dashboard Cite

Objective: We aimed to investigate the prevalence and type of BRAF V600 mutations and the associations with clinicopathological variables in primary skin nodular melanoma cases in Yogyakarta and Central Java, Indonesia using pyrosequencing. Results: BRAF V600 mutations of the V600E type were found in 21 (53.85%) specimens. The variant allele frequencies (VAFs) ranged from 5.07 to 94.70%, averaging 29.05%. However, most cases had low VAFs, with 13 (61.9%) specimens below 20% and 4 (19.05%) below 10%.

show abstract

“…Melanomas in Indonesia present distinct clinical features, showing different clinical presentations and histopathological subtypes from other Asian populations. As opposed to the acral lentiginous 4 melanoma subtype predominance in Asia, most cases from Indonesia are of the nodular subtype, which is associated with worse prognosis (6). The prevalence of BRAF V600 mutations in melanoma patients from Indonesia has also been shown to be relatively low.…”

Section: Introductionmentioning

confidence: 99%

BRAF V600 mutation profiling in primary skin nodular melanoma in Indonesia: an analysis using high resolution pyrosequencing

Rinonce

Aji

Hayati

et al. 2020

Preprint

View full text Add to dashboard Cite

Objective : We aimed to investigate the prevalence and type of BRAF V600 mutations and the associations with clinicopathological variables in primary skin nodular melanoma cases in Yogyakarta and Central Java, Indonesia using pyrosequencing. Results : BRAF V600 mutations of the V600E type were found in 21 (53.85%) specimens. The variant allele frequencies (VAFs) ranged from 5.07% to 94.70%, averaging 29.05%. However, most cases had low VAFs, with 13 (61.9%) specimens below 20% and 4 (19.05%) below 10%.

show abstract

Clinical and pathological profile of skin melanoma in Dr. Sardjito Hospital Yogyakarta, Indonesia

Cited by 3 publications

References 0 publications

Low BRAF V600 mutation prevalence in primary skin nodular melanoma in Indonesia: a real-time PCR detection among Javanese patients

Low BRAF V600 mutation prevalence in primary skin nodular melanoma in Indonesia: a real-time PCR detection among Javanese patients

BRAF V600 mutation profiling in primary skin nodular melanoma in Indonesia: an analysis using high resolution pyrosequencing

BRAF V600 mutation profiling in primary skin nodular melanoma in Indonesia: an analysis using high resolution pyrosequencing

Contact Info

Product

Resources

About