Clinical and pathological features of intraductal papillary neoplasm of the biliary tract and gallbladder

Bennett, Sean; Marginean, Esmeralda Celia; Paquin‐Gobeil, Melanie; Wasserman, Jason K.; Weaver, Joel; Mimeault, Richard; Balaa, Fady; Martel, Guillaume

doi:10.1111/hpb.12460

Cited by 44 publications

(36 citation statements)

References 25 publications

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“…According to its pathological features, IPMN-B can be divided into four types: pancreaticobiliary duct type, gastric type, intestinal type, and eosinophilic type [13]. According to the degree of atypia, it can be divided into: low or medium grade intraepithelial tumors, high grade intraepithelial tumors, related invasive cancers [14].…”

Section: Discussionmentioning

confidence: 99%

Intraductal papillary mucinous neoplasm of the intrahepatic bile ducts: a case report and literature review

jia

Zhang

et al. 2020

Preprint

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Background: Intraductal papillary mucinous neoplasm of the bile ducts (IPMN-B) is a rare malignant tumor originated from the epithelium of the bile duct. It can secrete a large amount of mucin to cause biliary obstruction. This disease has just been recognized in recent years.Case presentation: We found a 60-year-old woman with intermittent right upper abdominal pain. Imaging examination showed that the left intrahepatic bile duct was dilated with a solid mass. We had left hepatectomy. During the operation, there was colloidal mucus in the bile duct. There was a papillary mass on the wall of the bile duct. -to have developed into invasive adenocarcinoma. At a postoperative 6 months follow-up, the patient had no recurrence and is in good conditions. Conclusion: In our case, IPMN-B has underwent a malignant transformation at the early stage. Therefore, we think that surgical resection should be done as early as possible after the diagnosis of IPMN-B, so as to get a favorable prognosis.

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Section: Discussionmentioning

confidence: 99%

Intraductal papillary mucinous neoplasm of the intrahepatic bile ducts: a case report and literature review

jia

Zhang

et al. 2020

Preprint

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“…It is often asymptomatic, but compared to BilIN, it is more frequently associated with early symptoms of intermittent pain, jaundice or cholangitis (4).…”

Section: Discussionmentioning

confidence: 99%

Hemobilia due to intracholecystic papillary neoplasm

Cumpa¹,

Barahona²,

Capó³

et al. 2016

Rev Esp Enferm Dig

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We report the case of a 39-year-old patient who presented an episode of upper gastrointestinal bleeding due to hemobilia. The imaging tests showed the gallbladder occupied by solid tissue, with a diagnosis of intracholecystic papillary neoplasm after the cholecystectomy. The intracholecystic papillary neoplasm of the gallbladder is a newly established entity and it is considered a subtype of intraductal papillary neoplasm of the bile duct. Its presentation in the form of hemobilia has barely been described in the literature.

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“…Es una neoplasia muy poco frecuente; sin embargo, se ha logrado establecer que se trata de neoplasias preinvasivas, con una clara secuencia "adenoma-carcinoma" (Kozuka et al, 1982;Aldridge & Bismuth, 1990;Milchgrub et al, 1992;Sessa et al, 1994;Lee et al;Adsay et al;Kai, 2016); con un comportamiento biológico diferente al cáncer invasivo de estas localizaciones (Abraham et al, 2003;Adsay et al); caracterizado por un crecimiento intraluminal asociado a hipersecreción de mucina, al igual que los demás subtipos histológicos: pancreatobiliar, intestinal, gástrico y oncocítico (Bennett et al, 2015).…”

Section: Introductionunclassified

“…Existen escasos reportes en la literatura, la mayor parte de los cuales son de casos aislados (Almagro, 1985;Arunabh et al, 1988;Bazira et al, 1998;Kushima et al, 1996;Nagahama et al, 1997;Kosemehmetoglu et al, 2011;Resende et al, 2012;Hashimoto et al, 2014;Michalinos et al, 2016;Páez Cumpa et al, 2017); de reportes de menos de 10 casos (Araki et al, 1988;Diaz-Plasencia et al, 1994;Bennett et al); y de series entre 16 y hasta 123 casos (Albores-Saavedra et al, 2005;Adsay et al;Argon et al, 2016), siendo esta última la mayor de todas (Adsay et al). No obstante ello, entre todas, no suman más de 250 en total, y es posible, que en algunos casos pueda existir duplicidad de información (Tabla I).…”

Section: Introductionunclassified

Neoplasia Papilar Intracolecística. Reporte de un Caso y Revisión de la Evidencia Existente

Manterola

Bellolio²,

Otzen

et al. 2018

Int. J. Morphol.

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MANTEROLA, C.; BELLOLIO, E.; OTZEN, T. & DUQUE, G. Neoplasia papilar intracolecística. Reporte de un caso y revisión de la evidencia existente. Int. J. Morphol., 36(4):1485Morphol., 36(4): -1489Morphol., 36(4): , 2018. RESUMEN:La neoplasia papilar intracolecística (NPIC), es un tumor compuesto por células neoplásicas preinvasivas, que forman masas de hasta 1,0 cm, clínicamente detectables. El objetivo de este estudio fue reportar un caso de NPIC y revisar la evidencia existente. Se trata de un paciente sexo masculino, de 33 años de edad, asintomático, que en el curso de un examen de salud, se realiza una ecotomografía abdominal, en la que se verifica una lesión polipoide vesicular de 32 x 19 mm de diámetro. Se programa para colecistectomía electiva, la que se realizó por vía laparoscópica, cirugía que se pudo realizar sin inconvenientes. Una vez extirpado el espécimen, se fue a estudio histopatológico en el que tras un mapeo vesicular se concluye NPIC, colecistitis crónica inespecífica, colesterolosis y pólipos colesterínicos. El paciente ha evolucionado sin inconvenientes. Presentamos un caso de NPIC en un paciente joven, cuyo diagnóstico fue confirmado por anatomía patológica tras una colecistectomía electiva, descartándose la presencia de carcinoma invasivo y displasia de alto grado, por lo que el pronóstico es favorable.

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Clinical and pathological features of intraductal papillary neoplasm of the biliary tract and gallbladder

Abstract: IPNB/ICPN are rare precursor lesions that can affect the entire biliary epithelium. At pathology, the majority of patients have invasive carcinoma, thus warranting a radical resection. Patients with tumours expressing MUC1 appear to have worse OS and DFSs.

Cited by 44 publications

References 25 publications

Intraductal papillary mucinous neoplasm of the intrahepatic bile ducts: a case report and literature review

Intraductal papillary mucinous neoplasm of the intrahepatic bile ducts: a case report and literature review

Hemobilia due to intracholecystic papillary neoplasm

Neoplasia Papilar Intracolecística. Reporte de un Caso y Revisión de la Evidencia Existente

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