Clinical and pathological features of a prolonged type of acute intrahepatic cholestasis

Watanabe, Norihito; Takashimizu, Shinji; Kojima, Seiichiro; Kagawa, Tatehiro; Nishizaki, Yasuhiro; Mine, Tetsuya; Matsuzaki, Shinya

doi:10.1111/j.1872-034x.2007.00115.x

Cited by 30 publications

(21 citation statements)

References 32 publications

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“…The clinical signature of DILI is classified into hepatocellular injury, cholestasis or mixed. Cholestatic reactions resolve more slowly than hepatocellular type, and can lead to chronic ductopenia 19 …”

Section: Classification Of Dilimentioning

confidence: 99%

Recent status of drug‐induced liver injury

Takikawa

2008

Hepatology Research

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Drug-induced liver injury is an major cause of acute liver injury and the incidence of drug-induced liver injury seems to be increasing with an increase in the number of new drugs available. The diagnostic scale of drug-induced liver injury was been modified by the International Consensus Meeting during Digestive Disease Week, Japan 2004, which includes the score of the drug-lymphocyte stimulation test and eosinophilia. Although the modified diagnostic scale is useful, and widely used in Japan, there will be many issues to be investigated in the future. According to a recent survey of drug-induced liver injury cases in Japan, drug-induced liver injury from dietary supplements are increasing, as has been observed in foreign countries. More research is needed to elucidate the mechanisms of drug metabolism and the pathophysiology of liver injury by various drugs to prevent drug-induced liver injury.

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Section: Classification Of Dilimentioning

confidence: 99%

Recent status of drug‐induced liver injury

Takikawa

2008

Hepatology Research

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“…The biliary excretion of organic anions is mediated by the multidrug resistance protein 2 (Mrp2, Abcc2), which is defective in mutant hyperbilirubinemic rats 1 and in patients with Dubin–Johnson syndrome 2,3 . Decreased Mrp2 is also observed in patients with acute cholestasis 4 . In contrast, amidated bile acids are excreted into bile by the bile salt export pump (Bsep, Abcb11), 5 which is defective in patients with progressive familial intrahepatic cholestasis 2 6 …”

Section: Introductionmentioning

confidence: 99%

“…2,3 Decreased Mrp2 is also observed in patients with acute cholestasis. 4 In contrast, amidated bile acids are excreted into bile by the bile salt export pump (Bsep, Abcb11), 5 which is defective in patients with progressive familial intrahepatic cholestasis 2. 6 Genipin (Fig.…”

Section: Introductionmentioning

confidence: 99%

Effect of genipin on the biliary excretion of cholephilic compounds in rats

Mikami

Takikawa

2008

Hepatology Research

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“…While VBDS has been associated with a long list of agents, adequate attribution and documentation can be difficult and is not found in all reports. The prototype drug leading to this rare outcome is chlorpromazine which is well-known to cause acute cholestatic liver injury (37–39). …”

Section: Specific Chronic Injuriesmentioning

confidence: 99%

Long-Term Outcomes After Drug-Induced Liver Injury

Hayashi

Bjõrnsson

2018

Curr Hepatology Rep

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Purpose of the review: This review serves to update the reader on emerging data regarding a spectrum of drug-induced liver injury (DILI) outcomes that lie between complete resolution and acute liver failure. Such outcomes can range from mild chronic injury to late liver failure and mortality. Recent findings: Several large registries are maturing with large numbers of DILI cases thus shedding light on outcomes including chronic injury and late fatality. We cover definitions commonly used to describe resolution versus chronic injury and mortality due to DILI. We look at rates of occurrence for these different outcomes in major registries. Three specific types of chronic DILI that are illustrative but also easily missed by clinicians are also described. Summary: A small but important proportion of DILI cases do not resolve, going on to develop chronic injury and even liver failure. Defining and recognizing these cases is a challenge because DILI is rare, and chronic injury rarer still. Large registries are beginning to define these previously overlooked long term outcomes.

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Clinical and pathological features of a prolonged type of acute intrahepatic cholestasis

Cited by 30 publications

References 32 publications

Recent status of drug‐induced liver injury

Recent status of drug‐induced liver injury

Effect of genipin on the biliary excretion of cholephilic compounds in rats

Long-Term Outcomes After Drug-Induced Liver Injury

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