Clinical and pathological features of a cerebellar oligodendroglioma in a cat

Abstract

A cerebellar oligodendroglioma was responsible for the progressive development of neurological deficits in a six‐year‐old castrated male domestic longhaired cat. These abnormalities included a head tilt and loss of balance, nystagmus, proprioceptive deficits and eventually a fine head tremor and hypermetria of the forelimbs. The tumour was found to have destroyed most of the cerebellar grey matter, the flocculus, and the cerebellar roof nuclei on the right hand side. Increased peri‐axonal space and axonal vacuolation were visible in fibre tracts which connected to the cerebellum. The clinical signs and location of the tumour are related to the functional anatomy of the cerebellum.

Feline Intracranial Neoplasia: Retrospective Review of 160 Cases (1985–2001)

“…8,[43][44][45] To the best of our knowledge, the veterinary literature contains only 1 report describing astrocytomas and 2 reports describing oligodendrogliomas in the cat. [16][17][18] Glial tumors were the 4th most common tumor type in this study, with an incidence of 7.5%. Six cats had astrocytomas and 6 cats had oligodendrogliomas.…”

“…[4][5][6][7][8][9] There is little information, however, regarding intracranial tumors in cats, with the exception of a small series of retrospective studies on meningiomas [10][11][12][13][14][15] and occasional reports of other intracranial tumors, diagnostic methods, and treatment strategies. [16][17][18][19][20][21][22][23][24][25][26] As advanced imaging modalities such as magnetic resonance imaging (MRI) and computed tomography (CT) become more available to veterinary practitioners, the ability to diagnose intracranial neoplasia and provide specific treatment is increasing. Additional data on the frequency and behavior of feline brain tumors might improve the accuracy of antemortem diagnosis and help in determining the best treatment strategy.…”

Sudden unexpected death in a horse due to a cerebral oligodendroglioma

“…In animals, oligodendrogliomas have been described mainly in the dog (Fankhauser et al 1974). Single cases have also been observed in cattle (Innes and Saunders 1962), in a cat (Smith and Honhold 1988), in a kangaroo (Gastinger et al 1961) and in the mouse (Cottier and Luginbiihl 1961). No previous reports of oligodendrogliomas in horses can be found in the literature.…”

Clinical and Pathologic Features of Oligodendrogliomas in Two Cats

“…However, in view of these two cases, a similar location in the one well-documented case, and one other report, this area may represent a predilection site for feline oligodendrogliomas. 17,18 However, other cases were reported in the cerebral hemispheres. 12,17 The extensive growth of one tumor into the basilar subarachnoid space with entrapment of multiple cranial nerve roots is a common feature in human oligodendrogliomas.…”

“…6,12,17,19 There is only one case with a description of the clinical findings and microscopic pathology. 18 Two presumptive feline oligoastrocytomas have been reported. 3,4 Here, we report two feline cases of oligodendroglioma with results of magnetic resonance imaging (MRI), neurologic examination, cerebrospinal fluid (CSF) analysis, detailed microscopic and ultrastructural evaluation, and immunocytochemical staining for some marker antigens of oligodendroglia and myelin.…”