Clinical and pathological characteristics of intraductal proliferative lesions and coexist with invasive ductal carcinomas

Wang, Gangping; Zhang, Hong; Zhang, Zuo-Feng; Liang, Yun-Ai; Chen, Ying; Lan, Mei

doi:10.1007/s10330-013-1256-1

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…The cell of immunostaining for HIF-1α overexpression is more common in invasive mammary cancer than mammary cancer benign leisions. Our previous research shows there is no significance difference of HIF-1α expression between ADH and DCIS, and ADH as DCIS represent intraepithelial neoplasias, which indicates that ADH and DCIS are likely to represent precursor, albeit not obligate, to invasive mammary cancer [2,17]. We also detect differences in HIF-1α expression situation before and after chemotherapy of mammary cancer to neoadjuvant chemotherapy.…”

Section: Discussionmentioning

confidence: 47%

The Expressions of HIF-1a#945;, CA153, CEA and CA125 in Breast Cancer and Significance with Chemotherapy

Yu¹,

Yin²,

Wang³

et al. 2016

Proceedings of the 2016 International Conference on Biological Sciences and Technology

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Biomarker in tissue and serum plays significant roles in patient management and treatment and can be used as prognostic factors. For the diagnosis, treatment, prognosis study of breast cancer, we examined the expressions of Hypoxia inducible factor 1α (HIF-1α) in 128 cases mammary carcinoma tissues, and 43 cases serum levels of Cancer antigens153 (CA153), Cancer antigens125 (CA125) and CEA before and after neoadjuvant chemotherapy and analyze their relationship with clinicopathological factors such as metastasis, recurrence and chemotherapy. Our results demonstrated that the positive rates of HIF-1α were 68.75%, which were higher than that in DCIS, ADH, UDH (P<0.01, respectively). There was posive correlation in over-expression of HIF-1α with the level of ER or PR, histological grade, lymph node metastasis and distant metastasis of carcinomas (P<0.01, respectively), and the expressions of HIF-1α were not related with age (≤50 yr vs 50yr) and size of tumor (≤5cm vs >5cm) (P>0.05). Before and after therapy, the expression of HIF-1α had decreased significantly (P<0.05). The chemosensitivity of HIF-1α, CA153, and CEA positive group were worse than those of nagetive groups (P<0.05), however, there was no significant difference of chemosensitivity of CA125 before and after neoadjuvant chemotherapy. Biomarkers such as HIF-1α can be used as prognostic predictors in many malignancy and CA153 and CEA can be used as followed up potential factors of breast cancer chemosensitivity to help following up undergoing individualized chemotherapy.

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Section: Discussionmentioning

confidence: 47%

The Expressions of HIF-1a#945;, CA153, CEA and CA125 in Breast Cancer and Significance with Chemotherapy

Yu¹,

Yin²,

Wang³

et al. 2016

Proceedings of the 2016 International Conference on Biological Sciences and Technology

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“…In China, the incidence of breast cancer is relatively high, and the peak incidence is in advance, young breast cancer has become a major clinical type of breast cancer, a large number of patients died of breast cancer complications or serious organ metastasis each year [2][3]9]. The incidence rate of breast cancer in China was 2.55/100,000 in 2009, accounting for 16.81% of female malignancies, while the five year disease-free survival in patients with breast cancer has increased from 70% in 1980 to 85% in 2011 [3,10].…”

Section: Discussionmentioning

confidence: 99%

Significance of Combined Imaging BI-RADS Assessment in Breast Cancer and Pathology Comparison

Liu¹,

Zhou²,

Liu³

et al. 2016

Proceedings of the 2016 International Conference on Biological Sciences and Technology

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Abstract. Mammography (MG) is the only proven modality to reduce mortality of breast cancer and has been shown to reduce mortality from breast cancer, and ultrasonography (US) is a well-known adjunct to screening MG. BI-RADS classification is actually practical and correlation with histopathology on the palpable diagnostic cases. To explore the clinical value of combined detection of MG and US BI-RADS in the diagnosis of breast cancer, we examined 212 patients using MG and US (62 cases breast cancer and 150 cases benign leision). All selected cases were re-evaluated by BI-RADS MG alone, US alone, and combined MG and US. In the combined imaging assessment, BI-RADS 1-4a category was MG and US both no more than 4a, however, 4b-5a cacategory was considered as the score of MG and US both more than 4a. MG and US alone findings BI-RADS 1-4a level were 142 cases and 144 cases, respectively; 4b-5 level were 70 and 68, respectively; and for Combination, there were 166 cases 1-4a and 46 cases 4b-5 level. Our results demonstrated that the sensitivity of MG, US alone was 80.65% and 72.58 %, respectly; and specificity was 86.67 % and 84.67%, respectly. The sensitivity of MG and US in combination was 69.35%, however, the specificity was improved into 98.00%, and a positive predictive value was improved into 93.47%. The differences in specificity and positive predictive values between MG and combined imaging assessment, US and combined all were statistically significant (P<0.05). The specificity and positive predictive values of combined assessment was the highest, and the sensitivity and negative predictive values was the highest in the MG assessment. Combined imaging assessment is more effective in diagnosing breast lesions.

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“…In recent years in China, the incidence of breast carcinoma is relatively high, and the peak incidence is in advance, a large number of patients died of breast carcinoma complications or serious organ metastasis each year [3,11]. Breast carcinoma, like most other forms of malignancy, is mainly a multifactorial disease, occurring as a result of the combined effects of environmental and heritable factors [6,[12][13][14].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of COX-2 and VEGF in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy

Wang¹,

Wang²,

Ding³

et al. 2016

Proceedings of the 2016 International Conference on Biological Sciences and Technology

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In recent years, the incidence of breast cancer is signifcantly on the rise all over the world, hence, how to treat breast cancer, correctively evaluate the prognosis and find the postoperative recurrence of patients with breast cancer have been paid attention by more and more scholars all over the world. Biomarkers such as Cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in tissue can be used as prognostic factors in many malignancies. To analyze the relationship between the expressions of COX-2 and VEGF and clinicopathological features in breast cancer, we examined the expressions and clinical significance of COX-2 and VEGF in breast carcinom tissue (n=128), and their relationships with chemosensitivity in breast carcinoma (n=52). The study demonstrated that before and after chemotherapy, the expression of COX-2 had changed significantly from 68.75% down to 33.56% (P<0.05). Before neoadjuvant chemotherapy, the chemosensitivity of COX-2 positive expression was worse than the chemosensitivity of that nagetive expression (P<0.05), for VEGF, there was no differences significantly (P>0.05). The over-expression of COX-2 and VEGF might be important biological markers for invasion and metastasis of breast carcinomas. COX-2 can be used as predictors of breast cancer chemosensitivity to help develop individualized chemotherapy.

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Clinical and pathological characteristics of intraductal proliferative lesions and coexist with invasive ductal carcinomas

Cited by 5 publications

References 13 publications

The Expressions of HIF-1a#945;, CA153, CEA and CA125 in Breast Cancer and Significance with Chemotherapy

The Expressions of HIF-1a#945;, CA153, CEA and CA125 in Breast Cancer and Significance with Chemotherapy

Significance of Combined Imaging BI-RADS Assessment in Breast Cancer and Pathology Comparison

Prognostic Significance of COX-2 and VEGF in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy

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