Clinical and pathological characteristics of colorectal polyps in Iranian population

Khodadoostan, Mahsa; Fatemi, Reza; Maserat, Elham

doi:10.4314/eajph.v7i2.64717

Cited by 12 publications

(19 citation statements)

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“…This result was in agreement with a previous study, in which left-sided colorectal adenomas were more prevalent compared with right-sided ones (56 vs. 44%, respectively) (30). Another previous study, including a large sample of 7,590 adenomatous polyps, found that 76.5% of the adenomas were localized in the left and 23.5% in the right colon (31).…”

Section: (Adr %) Age Grouping --------------------------------------supporting

confidence: 93%

Adenoma detection rate in 41,010 patients from Southwest China

Cai

Liu

et al. 2015

Oncology Letters

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Abstract. Adenoma detection rate (ADR) is considered as an important predictor of the risk of interval colorectal cancer following a screening colonoscopy. A retrospective review of all the patients who underwent colonoscopy in the First Affiliated Hospital of Guangxi Medical University (Nanning, China) between 2003 and 2012 was performed, with the aim of estimating the ADR in Southwest China and determine the effects of age, gender and polyp location on ADR. Demographic information and data regarding the timing of the colonoscopy, number of polyps removed, polyp location and pathological types of polyps were collected and analyzed. The patients were grouped according to colonoscopy date, polyp location, gender and age. The χ 2 test was used to compare the ADR between the different age and gender groups and the Cochran-Armitage trend test was used to calculate the statistical significance of the ADR trend across age groups. A two-tailed value of P<0.05 was considered to indicate statistically significant differences. A total of 41,010 patients were included, of whom 7,219 were diagnosed with at least one adenoma on pathological examination. Therefore, the ADR value of the 41,010 patients screened in the present study was 17.6%. There was a statistically significant trend of increasing ADR with increasing age in both genders (P<0.05). In addition, the ADR of male patients was significantly higher compared with that of female patients in all age groups (all P<0.05). The ADR of patients aged >50 years was significantly higher compared with that of patients aged <50 years (28.8 vs. 11.0%, respectively; P<0.05). In addition, 20% of the cases of detected adenomas occurred in the rectum, 47% in the left colon and 33% in the right colon.

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Section: (Adr %) Age Grouping --------------------------------------supporting

confidence: 93%

Adenoma detection rate in 41,010 patients from Southwest China

Cai

Liu

et al. 2015

Oncology Letters

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“…In our study we found 53% of adenomas larger than 10 mm, similar to data reported by other authors (Hodadoostan et al -41% [16]). We also found that prevalence of adenomas larger than 10 mm was higher in patients with metabolic syndrome, which may be explained by faster adenoma growth in metabolic syndrome.…”

Section: Discussionsupporting

confidence: 93%

Prevalence of colonic adenomas in patients with metabolic syndrome

Gajecki¹,

Kempiński²,

Poniewierka³

2012

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Introduction: Seventy percent of colonic polyps are adenomas -benign neoplastic tissue deriving from epithelium with various grades of dysplasia. Metabolic syndrome is discussed as one of the risk factors for development of colonic adenomas. Aim: To evaluate the relation between metabolic syndrome and prevalence of colonic polyps. Material and methods: In 2008-2011, 151 patients (aged 50-70 years) from the city of Strzegom were enrolled in a prophylactic programme. Each patient had the following examinations performed: physical examination, abdomen ultrasound, chest X-ray, oesophagogastroduodenoscopy, colonoscopy, ECG and laboratory tests. In females mammography and gynaecological examination were performed, and in males prostate-specific antigen (PSA) level was evaluated. Results: The prevalence of adenomas was higher in patients with metabolic syndrome (33.3% vs. 20.6%, p < 0.05). Also higher prevalence of adenomas larger than 10 mm was found in patients with metabolic syndrome. HDL level above 95 mg% and HDL level 45-95 mg% with fulfilled criteria of metabolic syndrome were determined as risk factors of colonic adenoma development. Conclusions: Metabolic syndrome can be a risk factor for development of colonic adenomas. Adenoma growth can be accelerated in metabolic syndrome. HDL molecules can promote colonic proliferation and formation of adenomas.

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“…Among studies conducted outside Europe and North America, Tony et al (16) reported that among 124 patients diagnosed with a polyp, 79.5% were adenomas, 10% juvenile, 9% hyperplastic and 1.5% inflammatory. The most recent published study (to our knowledge) was conducted in Iran in 2010 (17). Of the 856 polyps examined, 85% were adenomas.…”

Section: Ethical Approvalmentioning

confidence: 99%

“…Our study is the first national study and one of the few recent analyses worldwide (16,17) exploring histopathological characteristics of colorectal polyps and their distribution. However, it carries certain limitations, among which it is worth mentioning that the study population comprises consecutive symptomatic patients and not a representative national sample.…”

Section: Strengths and Limitationsmentioning

confidence: 99%