Clinical and Pathological Characteristics of Gastric Cancer without Helicobacter Pylori Infection and its Background Gastric Mucosa

Yoshimura, Daisuke; Yoshimura, Rie; Mizutani, Tomohiro; Ochiai, Toshiaki; Kato, Seiya; Niho, Kojiro; Iwao, Risa; Kitagawa, Yusuke; Akutagawa, Muneki; Ikeda, Hiroko; Mukai, Kosuke; Nakashima, Akihiko; Ihara, Eikichi; Nakamura, Kazuhiko; Ogawa, Yoshihiro

doi:10.1016/s0016-5085(17)31170-8

Cited by 3 publications

(2 citation statements)

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“…The results of this study are similar to those in previous reports, with the mean age of patients with early HpUIGC being 55.7 ± 10.9 years and a median tumor size of 5 mm, which are considered important characteristics for detecting early HpUIGC. In the present study, the locations of the lesions were plotted with reference to Yoshimura et al [ 22 ]. The most common SRCC cases in the present study were all located in the border region between the fundus and pyloric glands, similar to previous reports.…”

Section: Discussionmentioning

confidence: 99%

Trends of Early Helicobacter pylori-Uninfected Gastric Cancer in an Aging Regional Area

Maeda,

Sasaki,

Ooi

et al. 2024

JCM

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Background/Objectives: We aimed to determine the trends over time and current status of early Helicobacter pylori-uninfected gastric cancer (HpUIGC) treatment in a region with an aging population. Methods: This retrospective, multi-center observational study was conducted at seven major general hospitals in Kagoshima Prefecture. From January 2009 to July 2022, 2091 patients who received endoscopic resection (ER) for early gastric cancer (EGC) were retrospectively enrolled, of which 35 were identified as early HpUIGC cases. Results: The number of ERs for EGC demonstrated a significant increasing trend from 2010 to 2021 (p = 0.01 for trend). Furthermore, the 12-year period from 2010 to 2021 was divided into an early and late phase every 6 years. In the early phase, there were 5 cases (0.7%) of early HpUIGC, while in the late phase, there were 25 cases (2.1%), indicating a significant increase in the proportion of ERs for early HpUIGC cases in the late phase (p = 0.02). Conclusions: The proportion of ERs for early HpUIGC, which are more common in relatively young patients, may be increasing as a proportion of all ERs for GC, even in areas of Japan with an aging population.

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Section: Discussionmentioning

confidence: 99%

Trends of Early Helicobacter pylori-Uninfected Gastric Cancer in an Aging Regional Area

Maeda,

Sasaki,

Ooi

et al. 2024

JCM

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“…Most GA-FG appear to be a type of Helicobacter pylori (Hp)-naïve gastric cancer. Histological types of Hp-naïve gastric cancers are generally dominated by undifferentiated adenocarcinoma and differentiated adenocarcinoma with low-grade atypia, including GA-FG [19].…”

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confidence: 99%

Diagnostic limitations of magnifying endoscopy with narrow-band imaging in early gastric cancer

et al. 2020

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Background and study aims Magnifying endoscopy with narrow band imaging (M-NBI) has made a huge contribution to endoscopic diagnosis of early gastric cancer (EGC). However, we sometimes encountered false-negative cases with M-NBI diagnosis (i. e., M-NBI diagnostic limitation lesion: M-NBI-DLL). However, clinicopathological features of M-NBI-DLLs have not been well elucidated. We aimed to clarify the clinicopathological features and histological reasons of M-NBI-DLLs. Patients and methods In this single-center retrospective study, M-NBI-DLLs were extracted from 456 EGCs resected endoscopically at our hospital. We defined histological types of M-NBI-DLLs and analyzed clinicopathologically to clarify histological reasons of M-NBI-DLLs. Results Of 456 EGCs, 48 lesions (10.5 %) of M-NBI-DLLs were enrolled. M-NBI-DLLs was classified into four histological types as follows: gastric adenocarcinoma of fundic-gland type (GA-FG, n = 25), gastric adenocarcinoma of fundic-gland mucosal type (GA-FGM, n = 1), differentiated adenocarcinoma (n = 14), and undifferentiated adenocarcinoma (n = 8). Thirty-nine lesions of M-NBI-DLLs were H. pylori-negative gastric cancers (39/47, 82.9 %). Histological reasons for M-NBI-DLLs were as follows: 1) completely covered with non-neoplastic mucosa (25/25 GA-FG, 8/8 undifferentiated adenocarcinoma); 2) well-differentiated adenocarcinoma with low-grade atypia (1/1 GA-FGM, 14/14 differentiated adenocarcinoma); 3) similarity of surface structure (10/14 differentiated adenocarcinoma); and 4) partially covered and/or mixed with a non-neoplastic mucosa (1/1 GA-FGM, 6/14 differentiated adenocarcinoma). Conclusions Diagnostic limitations of M-NBI depend on four distinct histological characteristics. For accurate diagnosis of M-NBI-DLLs, it may be necessary to fully understand endoscopic features of these lesions using white light imaging and M-NBI based on these histological characteristics and to take a precise biopsy.

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UEG Week 2019 Poster Presentations

2019

UEG Journal

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Clinical and Pathological Characteristics of Gastric Cancer without Helicobacter Pylori Infection and its Background Gastric Mucosa

Cited by 3 publications

References 0 publications

Trends of Early Helicobacter pylori-Uninfected Gastric Cancer in an Aging Regional Area

Trends of Early Helicobacter pylori-Uninfected Gastric Cancer in an Aging Regional Area

Diagnostic limitations of magnifying endoscopy with narrow-band imaging in early gastric cancer

UEG Week 2019 Poster Presentations

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