Clinical and Pathological Characteristics of Incidental Diagnostic Early Occult Malignancy After Risk-Reducing Salpingo-Oophorectomy in BRCA Mutation Carriers

Abstract

A 5.4% incidence of early occult malignancy in adnexal pathology of BSO was found in carriers of Ashkenazi Jewish BRCA mutations. Two cases with malignant origins within the fallopian tube, while sparing the ovaries in their entirety, support the fallopian tubes as the originating organ for some ovarian or peritoneal malignancies in BRCA mutation carriers.

The prevalence of occult ovarian cancer in the series of 155 consequently operated high risk asymptomatic patients – Slovenian population based study

“…According to the available literature, the prevalence of occult cancer found after RRSO varies from 2% to 17%. [13][14][15][16][17][18][19][20][21][22]28 In our study, the prevalence of occult cancer in BRCA1/2 positive women was 5.5%, which is similar to what Conner et al have found. 29 We detected fewer occult cancers than Powell et al who reported a rate of 7.9% and more than Reitsma et al (2.2%) and Finch et al (4.2%).…”

Prophylactic risk-reducing salpingo-oophorectomy in BRCA mutation carriers: what is going on in a region of northern Italy?

“…In premenopausal, hormone-sensitive breast cancer patients, an ovariectomy is also performed more easily for therapeutic oncologic purposes than inducing pharmacological menopause. The increased access to RRSO in breast cancer survivors has never been clearly reported before [13][14][15][16][17][18][19][20][21][22][23][24]. In the present study, the prevalence of BRCA mutations carriers undergoing RRSO that were breast cancer survivors is higher than observed in a previous study [12].…”

“…To date, this is the fifth largest case series of RRSO in BRCA-carriers from a multicentric data collection in a European region of northern Italy. The other similar RRSO case series found in the literature are reported in Table 3 [12][13][14][15][16][17][18][19][20][21][22][23][24].…”

Incidence and Characteristics of Unsuspected Neoplasia Discovered in High-Risk Women Undergoing Risk Reductive Bilateral Salpingooophorectomy

“…Contrary to Powell et al, 40 we found a higher incidence of occult carcinoma in women with a history of breast cancer. Compared with Lavie et al, 45 we only isolated occult malignancy in the fallopian tube of women undergoing RRBSO, whereas they identified 3 of 5 malignancies occurring in the ovary, with only 2 occurring in isolation within the fallopian tube. The difference in this finding likely stems from the difference in patient cohortVall of the women in their study were of Ashkenazi Jewish ancestry, whereas our study is specific to an Australian population.…”