Clinical and pathological characteristics of incidental and nonincidental papillary thyroid microcarcinoma in 339 patients

Vasileiadis, Ioannis; Karatzas, Theodore; Vasileiadis, Dimitrios; Kapetanakis, Stylianos; Charitoudis, Georgios; Karakostas, Efthimios; Kouraklis, Gregory

doi:10.1002/hed.23333

Cited by 44 publications

(57 citation statements)

References 24 publications

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“…NITMC, which presents with aggressive features like conventional TC, should be treated in a similar manner and a routine total thyroidectomy with central lymph node compartment dissection should be performed (35). Similar observations were noted in a study by Vasileiadis et al (36), which recorded 339 individuals with the papillary type of TMC, accounting for 12% of all patients who underwent surgery for thyroid disease. It was noted that bilaterality, autoimmune thyroid disease, a tumor size of >5 mm in diameter, multifocality and lymph node metastasis were significantly associated with non-incidental tumors.…”

Section: Tumor Size MM ---------------------------------------------supporting

confidence: 66%

Incidental and non-incidental thyroid microcarcinoma

et al. 2016

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Abstract. There is no clear therapeutic approach for thyroid microcarcinoma (TMC). This may be as a consequence of recent observations that have reported biologically different types of TMC, which should be treated differently. The objective of the present study was to compare incidental TMC (ITMC) and non-incidental TMC (NITMC) in order to assess the differences in the incidence, diagnostic results, clinicopathological characteristics and surgical treatment. The study consisted of a retrospective chart review of 3,218 patients consecutively admitted and surgically treated in a single institution due to thyroid pathology. A total of 246 (7.64%) patients presented with a thyroid malignancy, and 97 (39.43%) of these individuals were diagnosed with TMC; 37 (38.14%) patients exhibited ITMC and 60 (61.86%) exhibited NITMC. All 37 (100.00%) patients with ITMC exhibited a papillary type of cancer. In the NITMC group, 1 (1.67%) patient presented with follicular microcarcinoma, 1 (1.67%) individual with papillary-and follicular-type microcarcinoma, 1 (1.67%) individual with medullary microcarcinoma, and the remaining 57 (95.00%) patients presented with papillary microcarcinoma. The number of younger patients (<45 years old) was higher in the NITMC group, but this difference was not significant (P=0.205). In all patients with ITMC, ultrasound-guided fine-needle aspiration biopsy did not reveal malignant processes. In the NITMC group, the number of larger tumors (>5 mm) was significantly higher compared with that in the ITMC group (P<0.001). ITMC was significantly associated with multinodular goiter (MNG) (P<0.001). Amongst the NITMC group, 18.33% of patients presented with cervical lymph node involvement (P<0.001). Overall, the incidence of TMC is high, and consists of ITMC and NITMC, although the prevalence of NITMC is higher than that of ITMC. The majority of ITMCs and NITMCs are composed of a papillary type of cancer. The majority of ITMCs have dimensions ≤5 mm in diameter and are significantly associated with MNG. In comparison with ITMC, NITMC more often presents with aggressive features such as cervical lymph node metastases, so the surgical approach to this tumor should be more radical.

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Section: Tumor Size MM ---------------------------------------------supporting

confidence: 66%

Incidental and non-incidental thyroid microcarcinoma

et al. 2016

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“…The detection of multicentricity in thyroid cancer is important as it may affect treatment methods to be used. The studies in the literature report a multicentricity rate for papillary thyroid carcinoma ranging from 9.5% to 24.9%, and the rate of multricentricity was 38.9% in the present study (12,13). Pathological subtype is another factor affecting prognosis of papillary thyroid cancer.…”

Section: Discussionsupporting

confidence: 59%

Relationship Between Platelet Distribution Width and Papillary Thyroid Cancer

Yılmaz¹,

Kızıltan²

2017

Van Med J

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“…Our 12.1% rate is comparable to rates from other European countries, including Belgium, Italy (25,30,33) and Greece (17). Because Italy and Greece have no nuclear plants, we tend to exclude that our rate was influenced by the relative vicinity of our medical center and residence of patients to three nuclear plant units (82).…”

Section: Discussionmentioning

confidence: 54%

“…, has shown that one-third (n = 16) of the studies are on cohorts of thyroidectomized patients smaller than ours (n = 50 to 191, compared to 207), and oneseventh of the studies (n = 7) are on cohorts slightly greater than ours (256 to 8,132). Prevalence of ITC at surgery ranges between 2% and 40% (1,2,17,. In Europe, the frequency of ITC varies from 2.2% to 27.4%, and a similar wide range (3.3% to 33%) is observed in the United States.…”

Section: Discussionmentioning

confidence: 87%

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Preoperatively undiagnosed papillary thyroid carcinoma in patients thyroidectomized for benign multinodular goiter

Famà¹,

Sindoni²,

Cicciù³

et al. 2018

Archives of Endocrinology and Metabolism

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Objective: Incidental thyroid cancers (ITCs) are often microcarcinomas; among them, the most frequent histotype is the papillary one. The purpose of this study was to evaluate the rate of papillary thyroid cancer (PTC) in patients thyroidectomized for benign multinodular goiter. Subject and methods: We retrospectively evaluated the histological incidence of PTC in 207 consecutive patients who, in a 1-year period, underwent thyroidectomy for benign multinodular goiter. All patients came from an iodine-deficient area (Orleans, France) with three nuclear power stations located in the neighboring areas of the county town. Results: Overall, 25 thyroids (12.1%) harbored 37 PTC, of which 31 were microcarcinomas. In these 25 PTC patients, mean age was 55 ± 10 years (range 30-75), female:male ratio 20:5 (4:1). In 10 patients (40% of 25 and 4.8% of 207), PTCs were bilateral, and in 7 (2 with microPTCs) the thyroid capsule was infiltrated. These 7 patients underwent central and lateral cervical lymph node dissections, which revealed lymph node metastases in one and two cases, respectively. Radioiodine treatment was performed in 7 cases. Neither mortality nor transient and permanent nerve injuries were observed. Four (16%) transient hypocalcaemias occurred as early complications. At last follow-up visit (mean length of follow-up 17.2 ± 3.4 months), all patients were doing well and free of any clinical local recurrence or distant metastases. Conclusion: With a 12% risk that multinodular goiter harbors preoperatively unsuspected PTCs, which can have already infiltrated the capsule and that can be accompanied by PTC foci contralaterally, an adequate surgical approach has to be considered. Arch Endocrinol Metab. 2018;62(2):139-48

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Clinical and pathological characteristics of incidental and nonincidental papillary thyroid microcarcinoma in 339 patients

Cited by 44 publications

References 24 publications

Incidental and non-incidental thyroid microcarcinoma

Incidental and non-incidental thyroid microcarcinoma

Relationship Between Platelet Distribution Width and Papillary Thyroid Cancer

Preoperatively undiagnosed papillary thyroid carcinoma in patients thyroidectomized for benign multinodular goiter

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