Clinical and Pathological Analysis of 4910 Patients Who Received Renal Biopsies at a Single Center in Northeast China

Nie, Ping; Chen, Rui; Luo, Manyu; Dong, Chuan; Chen, Liangmei; Liu, Juan; Hu, Liangqian; Li, Bing; Luo, Ping

doi:10.1155/2019/6869179

Cited by 23 publications

(38 citation statements)

References 35 publications

(65 reference statements)

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“…Studies have shown a higher frequency of nephrotic syndrome in different glomerulopathies, mainly MCD, FSGS and MN 2,6,12,21,22 data also described in systematic reviews 17 , and mainly as a clinical presentation of primary glomerulopathies 16,18 . In IgAN, nephritic syndrome and proteinuria/hematuria prevailed, in agreement with other studies 6,18, 19,21 . In secondary forms, nephrotic syndrome and proteinuria/hematuria were prevalent in LN, nephrotic syndrome in DKD, nephrotic syndrome and proteinuria with loss of renal function in 2nd FSGS and monoclonal gammopathies, and nephritic syndrome in systemic vasculitis.…”

Section: Discussionsupporting

confidence: 92%

“…In the period from 2000 to 2018, the Nephrology and Radiology departments performed 538 and 513 renal biopsies, respectively. When comparing renal biopsies by performer, the total number of glomeruli in optical microscopy was signi cantly higher in biopsies done by nephrologists (median and interquartile range: 15 [10][11][12][13][14][15][16][17][18][19][20][21][22]) compared to those performed by radiologists (12[8-16]), p < 0.001. However, there was no difference in the total number of glomeruli in immuno uorescence (4[2-7] and 3 [2][3][4][5][6] respectively; p = 0.320), or in the number of non-representative biopsies (N = 14 and N = 15 respectively; p = 0.568).…”

Section: Resultsmentioning

confidence: 99%

“…A metanalysis of the epidemiology of glomerulonephritis in Africa showed a higher prevalence of minimal change disease (MCD) and FSGS 17 . In secondary glomerulopathies, studies have shown a higher prevalence of lupus nephritis (LN), diabetic kidney disease (DKD) and pauci-immune systemic vasculitis 8,11,18,19 , but with variations in its frequency over two decades 6,7,15 .…”

Section: Introductionmentioning

confidence: 99%

“…There are records of differences related to ethnicity, with Asians having more cases of NIgA 8,18 , afrodescendants of FSGS and caucasians of MN 16 . Additionally, variations related to the age group with regard to the distribution of histological types have been widely described 6,7,18,19 .…”

Section: Introductionmentioning

confidence: 99%

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The Spectrum of Biopsy-Proven Glomerular Diseases in a Tertiary Hospital in Southern Brazil

Thomé

Bianchini

Bringhenti

et al. 2021

Preprint

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Background The prevalence and distribution of glomerular diseases differs between countries, and the indication to perform a kidney biopsy varies in each center. In this study, we assessed the prevalence of primary and secondary glomerulopathies based on histological diagnosis, and their correlation with demographic and clinical data were evaluated. Methods It was included in the study 1051 kidney biopsies retrospectively reviewed between the years 2000 to 2018. Demographic, clinical and laboratory data of patients were assessed. The prevalence of primary glomerulonephritis (PG) and secondary glomerulopathies (SG), as well as tubulo-interstitial diseases (TID), hereditary nephropathies (HN) and other diagnosis, were described. The frequency of primary and secondary glomerulopathies was evaluated by age group, and their temporal variation in three time periods (2000–2005, 2006–2011, and 2012–2018) were reported. Results The prevalence of SG predominated (52.4%) followed by PG (29.6%), other diagnoses (10.7%), TID (6.6%) and HN (1.1%). In primary forms, focal segmental glomerulosclerosis (FSGS) prevailed (37.3%), followed by IgA nephropathy (IgAN, 24.4%), membranous nephropathy (MN, 18.6%) and minimal change disease (MCD, 8.4%). Lupus nephritis (LN, 41.1%) had the highest frequency in SG, and in sequence diabetic kidney disease (DKD, 17.8%), systemic vasculitis (SV, 10.2%) and secondary FSGS (2nd FSGS, 10%). Nephrotic syndrome was the most common clinical presentation in PG, and also in DRD and 2nd FSGS, whereas in IgAN and SV the nephritic syndrome was the main form of presentation. In the age group between 18–50 years, LN, FSGS and IgAN predominated, between 51–65 years the proportion of DKD and 2nd FSGS increased, and SV were more found in patients > 65 years. The temporal variation of PG in three time periods showed a statistically significant increase in IgAN (p = 0.001) and a reduction in FSGS (p < 0.001). In SG, there were a reduction in LN (p = 0.027) and increase in DKD (p < 0.001), with a tendency to decrease of 2nd FSGS (p = 0.053). Conclusions In this kidney biopsy registry, FSGS and IgAN were the prevalent diagnoses in PG, and LN and DKD in SG. Nephrotic syndrome was the major indication for biopsy. When comparing the temporal variation of glomerulopathies, there was a reduction in FSGS and an increase in IgAN in PGs, and in SGs a reduction of LN with an increase in cases of DKD.

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Section: Discussionsupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Spectrum of Biopsy-Proven Glomerular Diseases in a Tertiary Hospital in Southern Brazil

Thomé

Bianchini

Bringhenti

et al. 2021

Preprint

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“…We speculated that different types of thymopathologic type may lead to different types of renal pathology. The other reason may be, for 4,910 patients who received renal biopsies in China, the most common forms of primary glomerulonephritis were membranous nephropathy (MN,37.2%) and IgA nephropathy (IgAN,29.9%) [17] . With the same study area of Karras' study, Simon's study showed that the most common primary glomerular diseases was also IgAN (2.4/1000, 3.6/1000 in males and 1.3/1000 in females) in 898 patients in a region of France [18] .…”

Section: Discussionmentioning

confidence: 99%

Thymoma-associated nephrotic syndrome: report of seven cases

He¹,

Peng²,

Xu³

et al. 2019

Preprint

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Background: Thymoma is often associated with a series of paraneoplastic syndromes. Among them, thymoma-related nephrotic syndrome is much rare.Methods: This retrospective study collected data from patients with thymoma and renal involvement in Xiangya Hospital, Central South University in a period of 5 years to investigate the clinical characteristics of thymoma-associated nephrotic syndrome.Results: Seven patients were studied (age: 51.1±21.4 years old; male/female ratio: 5/2). Among them, thymic pathology revealed 2 cases of type A and 1 case of type B3, myasthenia gravis (MG) was found in 1 out of 7 cases. Renal pathology showed 2 cases of FSGS and 1 case of IgA nephropathy. 2 out of 7 cases who received combined therapy of steroid and immunosuppressive drugs achieved complete remission. Despite 3 out of 7 cases received surgical excision of thymoma, 2 of them experienced treatment failure in nephrotic syndrome.Conclusions: nephrotic syndrome can be associated with thymoma. The FSGS is the most frequent thymoma-associated glomerular lesion in this study. IgA nephropathy may be another pathological type in thymoma-associated NS. Despite after surgical excision, long treatment periods with high dosage of steroid combined with immunosuppressants were needed to achieve complete remission.

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Diagnosis and treatment of IgA nephropathy and IgA vasculitis nephritis in Chinese children

Zhong

Ding

2022

Pediatr Nephrol

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IgA nephropathy (IgAN) and IgA vasculitis-associated nephritis (IgAVN) are among the most frequent childhood glomerular diseases and are characterized by significant variability in clinical manifestations, pathological presentation and long-term outcomes. IgAVN, alternatively called purpura nephritis, is pathologically indistinguishable from kidney-limited IgAN. In Chinese children, the clinical presentations and pathological manifestations of IgAN and IgAVN are variable. The severity of proteinuria and abnormalities in kidney function and blood pressure of children in China are comparable to those of children in Europe, the USA, and Japan. Compared to Caucasian children and Japanese children, crescents were more common in Chinese children with IgAN or IgAVN. Approximately 10–20% of childhood IgAN or IgAVN progresses to impaired kidney function in China. Since 2007, a series of guidelines on the diagnosis and treatment of pediatric kidney diseases has been published following the principles of evidence-based medicine. However, a large difference exists between the Chinese evidence-based guidelines and the guidelines developed by Kidney Disease: Improving Global Outcomes (KDIGO) in 2021. Chinese children with IgAN or IgAVN were more likely to be treated with steroids or immunosuppressive agents. Further studies exploring the optimal treatment regimen for childhood IgAN or IgAVN are needed in the future.

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Clinical and Pathological Analysis of 4910 Patients Who Received Renal Biopsies at a Single Center in Northeast China

Cited by 23 publications

References 35 publications

The Spectrum of Biopsy-Proven Glomerular Diseases in a Tertiary Hospital in Southern Brazil

The Spectrum of Biopsy-Proven Glomerular Diseases in a Tertiary Hospital in Southern Brazil

Thymoma-associated nephrotic syndrome: report of seven cases

Diagnosis and treatment of IgA nephropathy and IgA vasculitis nephritis in Chinese children

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