2006
DOI: 10.1016/j.ygyno.2005.06.065
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Clinical and pathologic findings of prophylactic salpingo-oophorectomies in 159 BRCA1 and BRCA2 carriers

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Cited by 345 publications
(221 citation statements)
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“…Recently, Finch et al described a plausible origin in the fallopian tube for five of their seven cases, in the form of a non-invasive (intraepithelial) carcinoma. 9 Medeiros et al reported that of five consecutive early carcinomas detected in BRCA+ women, all were in the fallopian tube, and were either in the fimbria or ampullary region, similar to other reports. 10,11 A followup study by Kindelberger et al reported that approximately one-half of carcinomas classified as ovarian serous neoplasms were associated with intra-epithelial carcinomas of the fimbria.…”
Section: Introductionsupporting
confidence: 76%
See 1 more Smart Citation
“…Recently, Finch et al described a plausible origin in the fallopian tube for five of their seven cases, in the form of a non-invasive (intraepithelial) carcinoma. 9 Medeiros et al reported that of five consecutive early carcinomas detected in BRCA+ women, all were in the fallopian tube, and were either in the fimbria or ampullary region, similar to other reports. 10,11 A followup study by Kindelberger et al reported that approximately one-half of carcinomas classified as ovarian serous neoplasms were associated with intra-epithelial carcinomas of the fimbria.…”
Section: Introductionsupporting
confidence: 76%
“…9,10,11,14,19 In contrast to symptomatic BRCA+ women with ovarian cancer whose tumors have been classified as ovarian in over 90%, early cancers detected in the asymptomatic women have been attributed to the fallopian tubes in up to 100% of studies. 19,20 Supporting this origin has been a recently described entity in the benign tubal mucosathe p53 signature -that shares several attributes with early serous carcinomas (tubal intraepithelial carcinomas), including strong staining for p53, predominately distal (fimbria) tubal location, involvement of secretory cells, and evidence of DNA damage with frequent p53 mutations.…”
Section: Discussionmentioning
confidence: 99%
“…2 Efforts to identify the source of serous cancers have revealed that the oviduct, particularly the fimbriated end, is responsible for a larger proportion of serous cancers than previously thought, both in women with BRCA1 or BRCA2 mutations and the general population. [3][4][5][6][7] A serous cancer precursor has been proposed to arise in the distal oviduct. It may begin with TP53 mutations in secretory cells, leading to a clonally derived population with altered expression of p53 in the setting of DNA damage (H2AX).…”
mentioning
confidence: 99%
“…[8][9][10] Serous intraepithelial carcinoma is the most common (B80-85%) gynecologic malignancy detected in risk reducing salpingo-oophorectomies of women at genetic risk (BRCA1 or BRCA2 mutations) and has been detected in approximately one-half of randomly selected women with advanced serous cancer. 3,7,11 For this reason, the distal tube is now considered an important site of origin for serous cancer.…”
mentioning
confidence: 99%
“…1 These include the frequent discovery of early serous cancers-termed tubal intraepithelial carcinomas-in the tubal fimbriae of women undergoing risk reducing salpingo-oophorectomy for germ-line BRCA1 or BRCA2 mutations, the observation of similar early cancers in 35-60% of un-selected women with fully developed pelvic serous cancer, and the description of a precursor condition in benign tubal mucosa with altered TP53 expression, termed the 'p53 signature'. [2][3][4][5][6][7][8][9][10] The latter has focused attention on the early molecular changes that may occur before the onset of either tubal intraepithelial or invasive serous carcinoma in the fallopian tube. Although the p53 signature, by virtue of its location (fimbria), p53 staining, evidence of DNA damage and proximity to intraepithelial carcinomas, is a presumptive direct precursor to intraepithelial carcinoma, a range of other discrete epithelial cell expansions have been described, termed secretory cell outgrowths or SCOUTs.…”
mentioning
confidence: 99%