Clinical and pathogenetic value of nitric oxide measurement in the blood of patients with bronchial asthma and essential hypertensio

Shakhanov, A. V.; Валерьевич, Шаханов Антон; Belskikh, Eduard; Сергеевич, Бельских Эдуард; Lunyakov, V A; Анатольевич, Луняков Вадим; Uryasev, Oleg; Михайлович, Урясьев Олег

doi:10.17750/kmj2017-492

Cited by 3 publications

(2 citation statements)

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“…Одним из возможных механизмов такого влияния является нарушение синтеза оксида азота (NO), который считается сигнальной молекулой межклеточного взаимодействия [3]. Синтез NO в эндотелии регулирует тонус сосудов, кровоток и артериальное давление, при этом нарушение его выработки способствует развитию артериальной гипертензии и формированию эндотелиальной дисфункции [4][5][6][7]. Кроме того, NO рассматривается как регулятор тонуса и просвета дыхательных путей, а в малых концентрациях препятствует бронхоспазму, что важно в предотвращении развития бронхиальной астмы [8][9][10].…”

Section: Effect Of the Nos3 786c/t Polymorphism On The Levels Of Nitric Oxide In Patients With Asthma And Comorbid Hypertensionunclassified

“…В организме NO синтезируется из L-аргинина при участии группы цитохром P-450-подобных гемопротеинов -синтаз оксида азота (NOS), включающих три известные изоформы: нейронную (nNOS), макрофагальную (iNOS) и эндотелиальную (eNOS) [5]. Изоформы являются продуктами экспрессии генов NOS1, NOS2 и NOS3 соответственно.…”

Section: Effect Of the Nos3 786c/t Polymorphism On The Levels Of Nitric Oxide In Patients With Asthma And Comorbid Hypertensionunclassified

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Влияние Полиморфизма NOS3 786c/T На Уровень Оксида Азота У Коморбидных Больных Бронхиальной Астмой И Гипертонической Болезнью

Shakhanov¹,

Урясьев²

2018

Вестник РГМУ

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Section: Effect Of the Nos3 786c/t Polymorphism On The Levels Of Nitric Oxide In Patients With Asthma And Comorbid Hypertensionunclassified

Влияние Полиморфизма NOS3 786c/T На Уровень Оксида Азота У Коморбидных Больных Бронхиальной Астмой И Гипертонической Болезнью

Shakhanov¹,

Урясьев²

2018

Вестник РГМУ

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Variants of <i>NOS3</i> gene polymorphism and lung function features in northerners

Bezmenova

Vdovenko

Averyanova

2023

Bûlletenʹ fiziologii i patologii dyhaniâ

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Introduction. The study on polymorphic variants of the gene of endothelial nitric oxide synthase is important for understanding the genetic basis of the respiration system readjustments, particularly at adaptation to the North conditions. Aim. This research explored the occurrence of -786 T>S (rs2070744) polymorphism in the NOS3 gene and its correlations with indicators of the lung function in northern residents. Materials and methods. One hundred and twentyfive male volunteers, Caucasian by ethnicity of the Magadan Region, participated in continuous cross-sectional study. The mean age of the subjects was 41.4±1.3 yrs. The examinees underwent SNP testing of the -786 T>S (rs2070744) polymorphism of the NOS3 gene by polymerase chain reaction. Lung function flow-volume indicators was assessed using a spiroanalyzer KM-AR-01 Diamant-S (Russia), and a series of heart rate variability indicators were analyzed with the Varicard complex. Results. In the surveyed selection of northerners, the distribution of frequencies of alleles and genotypes of the NOS3 locus corresponded to the Hardy-Weinberg equilibrium law (χ2 =0.13; p=0.714). The NOS3 allele*T frequency was 64.57%, the NOS3*C allele concentration was 35.43%. The following genotype picture was observed in the examined male Northerners: -786 TT – 41.96%, -786 TC – 45.76%, and -786 CC – 12.28%. The analysis of the lung function revealed the worst impairments in volume-velocity variables (MEF25-75 84±1,2%) which were characteristic of those northern men (a group of subjects with the TT genotype) who did not have -786T >C (rs2070744) polymorphism of the NOS3 gene in their genotype as compared to the minor allele carriers (TT+CC genotype – MEF25-75 94±2,1%). In addition, heart rate variability indicators showed the parasympathetic link of the autonomic nervous system that prevailed in the same group. Conclusion. The studies allowed for the finding of reduced values of volume-velocity indices of the lung function in those male subjects whose genotype had no NOS3 allele*C (TT homozygotes). The findings were observed along with the prevailing parasympathetic link in the heart rate regulation, which may indicate compensatory adaptive mechanisms aimed at optimizing the lung function when adapting to the extreme climatic factors of the North. Therefore, we can assume that the TT genotype appears to be a selective advantage at adaptation to the cold. Following on from this, the TT genotype Northerners can be considered to be the most adapted for living in the conditions of the North.

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Markers of Angiogenesis in Patients With Alopecia Areata

Сербина

2020

IMJ

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This study was aimed to evaluate the level of production of angiogenesis markers, namely VEGF, sVEGFR1, EGF and NO system in 67 patients with alopecia areata, depending on the pathology severity and activity. The content of stable metabolites of NO (NO2 and NO3) and NOS was studied in blood plasma using a spectrophotometric method. Growth factors and sVEGFR1 were investigated in serum by solid enzyme−linked immunosorbent assay. At an active stage with a moderate to serious severity of alopecia areata, the VEGF value was significantly higher. In chronic course, the VEGF level was significantly decreased at all severity levels, but the minimum was observed in the patients with a severe stage. The most significant decrease in the concentration of sVEGFR1, an increase in the content of EGF was diagnosed at an active stage with a severe alopecia areata. With signs of disease progression to severe stage, the level of NO, NO3, iNOS was as high as possible. At a chronic stage, their significance was significantly reduced relative to secretion in active manifestations of the disease (p < 0.01). In patients at an active stage with moderate and severe course of alopecia areata, the content of NO2 and cNOS was significantly lower than the level of indices at chronic disease. Correlation analysis revealed the existence of complex relationships between angiogenic factors, features of the disease course. Identified disorders can create conditions for the development of endothelial dysfunction and indicate a direct involvement of them into the mechanisms of formation of alopecia areata. Key words: alopecia areata, angiogenesis, endothelial dysfunction.

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Clinical and pathogenetic value of nitric oxide measurement in the blood of patients with bronchial asthma and essential hypertensio

Cited by 3 publications

References 6 publications

Влияние Полиморфизма NOS3 786c/T На Уровень Оксида Азота У Коморбидных Больных Бронхиальной Астмой И Гипертонической Болезнью

Влияние Полиморфизма NOS3 786c/T На Уровень Оксида Азота У Коморбидных Больных Бронхиальной Астмой И Гипертонической Болезнью

Variants of <i>NOS3</i> gene polymorphism and lung function features in northerners

Markers of Angiogenesis in Patients With Alopecia Areata

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