Clinical and neurological abnormalities in adult celiac disease

Cicarelli, Giulio; Rocca, Giorgio Della; Amboni, Marianna; Ciacci, Carolina; Mazzacca, G; Filla, Alessandro; Barone, Paolo

doi:10.1007/s10072-003-0181-4

Cited by 120 publications

(107 citation statements)

References 20 publications

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“…After every reflux, there is a peristaltic wave in oesophagus which clears the gastric contents (16,33) . Almost 20% of adults complain of atleast 1 episode of heartburn/week and about 10% of them complain of daily episode of heartburn due to various trigerring factors mainly stress and sedentary lifestyle (8,14,45) .…”

Section: Discussion and Conclusion:-mentioning

confidence: 99%

Case Study of Gastro-Oesophageal Reflux Disease (Gerd) v/ S Migraine: Do They Mingle or Is It a Myth.

MS¹

2017

IJAR

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Introduction: Over the years, there has been a dilemma regarding arriving at a diagnosis for headache pertaining to its variety of causes. One of the most common overlooked cause in the present day scenario for headache is GERD and Migraine. On day to day basis, we come across varied patient symptomatology which has indeed made us give a second thought to prescribe on management. Aim and Objective: To study if GERD and Migraine actually co-exist or they have a separate root cause for headache and also how change in lifestyle has an impact on health. Methodology: A study of random sample of 450 patients was conducted based on clinical evaluation for diagnosis and conservative management for the same was advised emphasising particularly on lifestyle modification. Results:The results drawn were compared by tabulating them into 3 groups with the two conditions taken as a separate entity and third when the two being mingled to conclude if interlink exists between the two conditions or purely is it a myth. Conclusion: Intermingling of GERD and Migraine was noted predominantly in our study rather than their separate existence.

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Section: Discussion and Conclusion:-mentioning

confidence: 99%

Case Study of Gastro-Oesophageal Reflux Disease (Gerd) v/ S Migraine: Do They Mingle or Is It a Myth.

MS¹

2017

IJAR

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“…Carta et al [73] found a significantly higher number of CD patients met the criteria for lifetime and 6-month major depressive disorder and panic disorder compared to controls. Other studies have reported higher rates of social phobia [74], anxiety [75,76], depression [74,77,78], and dysthymia [45]. A metaanalysis on anxiety and depression in CD found that depression is more common and more severe in adults with CD compared to normal controls.…”

Section: Depression and Anxietymentioning

confidence: 97%

“…Peripheral neuropathy is the second most frequent neurologic complication in CD patients [44] and has been reported in up to 50% of cases [28,45]. Cooke and Smith [34] reported that among 16 CD patients, neuropathy was the main cause of death in 4 patients and a significant contributing factor in another 4.…”

Section: Neuropathymentioning

confidence: 99%

Neuropsychiatric Features of Celiac Disease

Arnone

Conti²

2016

IJCD

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Celiac disease (CD) is a T-cell mediated genetically inherited autoimmune disease that has evolved over time. Formerly considered a pediatric disease, the rate of occurrence is now observed in individuals ranging from early childhood to senescence. Strict adherence to a gluten-free diet is the only currently available treatment for CD in order for individuals to avert future complications and malignancies. In the United States, the disease has shown widespread incidence and prevalence rates and affects 1% of the total population in not-at-risk groups. This number translates into 1 out of 133 people in the United States affected, making the disease almost 100 times more common than previously considered. While histological, genetic, incidence and prevalence of disease and quality of life research studies are replete in the extant literature, up until recently, neurological and psychological manifestations have also been studied among this cohort in relation to CD. Neurological conditions such as ataxia and neuropathy in CD have received the most research attention while much less attention has been paid to psychiatric conditions and cognitive functioning. The findings on cognitive functioning in CD have revolved largely around anecdotal reports and small clinical trials totaling approximately 200 patients of varying ages. Studies reporting neuropsychological test data are few and often do not include comprehensive test batteries in which to draw further conclusions on specific cognitive deficits. Larger, well-controlled studies are needed in order to form optimal diagnosis and implementation of specific support measures for individuals living with CD across the lifespan.

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“…8 Headaches, paresthesia, hyporeflexia, weakness, and vibratory sense reduction were reported to be more prevalent in CD patients vs controls. 9 These same symptoms were more prevalent in CD patients who did not strictly follow a GFD vs those who were compliant with GFD.…”

Section: Introductionmentioning

confidence: 92%

Improvement in Chronic Muscle Fasciculations With Dietary Change: A Suspected Case of Gluten Neuropathy

Anderson

Pitsinger

2014

Journal of Chiropractic Medicine

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Objective: The purpose of this case report is to describe a patient with chronic, multisite muscle fasciculations who presented to a chiropractic teaching clinic and was treated with dietary modifications. Clinical features: A 28-year-old man had muscle fasciculations of 2 years. The fasciculations began in his eye and progressed to the lips and lower extremities. In addition, he had gastrointestinal distress and fatigue. The patient was previously diagnosed as having wheat allergy at the age of 24 but was not compliant with a gluten-free diet at that time. Food sensitivity testing revealed immunoglobulin G-based sensitivity to multiple foods, including many different grains and dairy products. The working diagnosis was gluten neuropathy. Intervention and outcome: Within 6 months of complying with dietary restrictions based on the sensitivity testing, the patient's muscle fasciculations completely resolved. The other complaints of brain fog, fatigue, and gastrointestinal distress also improved. Conclusions: This report describes improvement in chronic, widespread muscle fasciculations and various other systemic symptoms with dietary changes. There is strong suspicion that this case represents one of gluten neuropathy, although testing for celiac disease specifically was not performed.

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Clinical and neurological abnormalities in adult celiac disease

Cited by 120 publications

References 20 publications

Case Study of Gastro-Oesophageal Reflux Disease (Gerd) v/ S Migraine: Do They Mingle or Is It a Myth.

Case Study of Gastro-Oesophageal Reflux Disease (Gerd) v/ S Migraine: Do They Mingle or Is It a Myth.

Neuropsychiatric Features of Celiac Disease

Improvement in Chronic Muscle Fasciculations With Dietary Change: A Suspected Case of Gluten Neuropathy

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