Clinical and mycological features of dermatophytosis in renal transplant recipients

Selvi, GS; Kamalam, A.; Ajithados, K.; Janaki, C; Thambiah, A. S.

doi:10.1046/j.1439-0507.1999.00405.x

Cited by 31 publications

(15 citation statements)

References 11 publications

(13 reference statements)

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“…Additionally, it has been suggested that proximal subungual white onychomycosis could be considered an indicator of iatrogenic immunosuppression. 28 On the other hand, Virgili and colleagues noted that the occurrence of onychomycosis in renal transplant recipients is similar to that found in the immunocompetent population. 29 …”

Section: Immunocompromised Patientsmentioning

confidence: 82%

“…Dermatophytes were the main etiologic organism responsible for the fungal infection, with T. rubrum, T. mentagrophytes, and Microsporum canis being reported. 27 The prevalence of dermatophytosis in renal transplant recipients has been observed to be high at 42%, 28 mostly as a result of the persistent immunosuppressive therapy required of these patients; it is not surprising that these patients would be more susceptible to fungal infections. Additionally, it has been suggested that proximal subungual white onychomycosis could be considered an indicator of iatrogenic immunosuppression.…”

Section: Immunocompromised Patientsmentioning

confidence: 99%

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Prevalence and Epidemiology of Onychomycosis

2006

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The prevalence of onychomycosis has been estimated at approximately 6.48% (95% confidence interval 6.09-6.88%) within the Canadian population. Dermatophytes are the most commonly cultured organisms, appearing in approximately 75 to 91% of nails with fungal involvement, with Trichophyton rubrum and Tricophyton mentagrophytes most commonly isolated. However, Candida spp and nondermatophyte molds are also sometimes cultured. The most common presentation is distal and lateral subungual onychomycosis (DLSO), which can involve 75% of patients with pedal onychomycosis. The distribution of DLSO, superficial white onychomycosis, and proximal subungual onychomycosis (PSO) has been reported to be 360:59:1 in patients with mycologic confirmation of onychomycosis; however, some reported that the incidence of PSO is slightly higher in immunocom-promised individuals. Age, gender, family history, and the presence of tinea pedis are all elements associated with a nail fungal infection. In addition, many conditions, including diabetes mellitus, immune disorders, and vascular disease, have been associated with the presence of onychomycosis. When choosing the best treatment regimen for individuals with onychomycosis, it is very important to consider all of the factors involved, including the infecting species, the presentation of the disease, the level of disease progression, and its predisposing factors.

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Section: Immunocompromised Patientsmentioning

confidence: 82%

Section: Immunocompromised Patientsmentioning

confidence: 99%

Prevalence and Epidemiology of Onychomycosis

2006

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“…We found T. rubrum to be the most common dermatophyte in both RTRs and control subjects, a finding similar to that documented in several previous reports (4). However, some other studies with RTRs showed T. mentagrophytes to be the major isolate (10, 11, 15).…”

Section: Discussionmentioning

confidence: 96%

Skin infections in Egyptian renal transplant recipients

Bakr

Elsawy

Hamdy

et al. 2010

Transplant Infectious Dis

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Our RTRs have higher prevalence rates of folliculitis and superficial fungal infections than the healthy population and they should be searched for in every patient with renal transplantation to ensure early treatment and avoid complications. Low-dose ketoconazole should be considered in renal transplant populations with high rates of superficial fungal infections, as it may reduce risk of such infections.

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“…Interestingly, there have been reported cases of HIV‐positive patients cured for onychomycosis after their immune systems were restored by combined antiretroviral therapy or highly active antiretroviral therapy . It should be noted that fungal infections can spread faster in immunocompromised patients, and clinical presentations that are generally more difficult to treat are more frequently encountered in this subpopulation …”

Section: Special Populationsmentioning

confidence: 99%

Global perspectives for the management of onychomycosis

et al. 2018

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Onychomycosis is a fungal nail infection caused by dermatophytes, nondermatophyte molds, and yeasts. This difficult‐to‐treat chronic infection has a tendency to relapse despite treatment. This paper aims to offer a global perspective on onychomycosis management from expert physicians from around the world. Overall, the majority of experts surveyed used systemic, topical, and combination treatments approved in their countries and monitored patients based on the product insert or government recommendations. Although the basics of treating onychomycosis were similar between countries, slight differences in onychomycosis management between countries were found. These differences were mainly due to different approaches to adjunctive therapy, rating the severity of disease and use of prophylaxis treatment. A global perspective on the treatment of onychomycosis provides a framework of success for the committed clinician with appreciation of how onychomycosis is managed worldwide.

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Clinical and mycological features of dermatophytosis in renal transplant recipients

Cited by 31 publications

References 11 publications

Prevalence and Epidemiology of Onychomycosis

Prevalence and Epidemiology of Onychomycosis

Skin infections in Egyptian renal transplant recipients

Global perspectives for the management of onychomycosis

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