Clinical and mycological characteristics of keratitis caused by Colletotrichum gloeosporioides: A case report and review of literature

Abstract

Introduction: Colletotrichum species are well-known plant pathogens, which have been increasingly reported as the cause of keratitis or subcutaneous lesions in humans. In this study we reported a rare case of fungal keratitis from Iran and reviewed the literature.
 Case Presentation: A 69-year-old man whose right eye was injured by herbal material was examined by slit-lamp biomicroscopy and mycology investigation of corneal scrapings was done. The grown filamentous fungal was identified as Colletotrichum gloeosporioides based on morphological characteristics and DNA sequence of the internal transcribed spacer region. The isolated strain was sensitive to amphotericin B, caspofungin, anidolafungin, micafungin, voriconazole, and relatively resistant to fluconazole, and itraconazole. Patient was successfully treated with voriconazole.
 Conclusions: This report highlights that the early and accurate identification and therapy can helpful to management keratitis caused by C. gloeosporioides.

Colletotrichum asianum: A Novel Phytopathogen Causing Human Infection—A Case Report

“…Since 2015, 15 cases of C. gloeosporioides keratitis have been reported until now. 10 Among them, only in 1 patient was evisceration performed because of endophthalmitis, and others responded well to topical voriconazole, natamycin, or amphotericin B. Both of our patients showed a healing response in 4 weeks, and they responded well to natamycin and voriconazole.…”

“…Both of our patients showed a healing response in 4 weeks, and they responded well to natamycin and voriconazole. 10 A good response of Colletotrichum corneal ulcers to natamycin, ciprofloxacin, and 5-flucytosine was reported by Kaliamurthy et al in their series of 7 patients, of whom 5 patients showed complete recovery. 8 The infective keratitis caused by most of the Colletotrichum sp showed good prognosis; only few species such as C. graminicola , first reported by Ritterband et al, were difficult to treat, and therapeutic keratoplasty (TPK) was performed twice to obtain a maximal healing response.…”

Multiomics Reveals Mechanisms of Alternaria oxytropis Inhibiting Pathogenic Fungi in Oxytropis ochrocephala

“…26 Less abundant Ascomycota in the EI group exhibited that the presence of A. oxytropis decreased the risk of O. ochrocephala being infected with fungal diseases of the Ascomycota phylum in this study. Leptosphae-ria, 27 Colletotrichum, 28 and Comoclathris 12 are well-known plant pathogens. Leptosphaeria can induce diseases of rape 29 and other plants, causing serious economic losses, and many toxic secondary metabolites have been isolated from Leptosphaeria-infected plants.…”

Fungal keratitis caused by Colletotrichum truncatum: a rare case report

“…Colletotrichum species are common plant pathogens in tropical and subtropical regions around the world, which can cause rot or necrosis of plant stems and roots, resulting in a large amount of economic losses in agriculture. However, in recent years, there have also been reports of anthrax that causes keratitis and endophthalmitis [8,9] . Ocular trauma and initial spore attachment were the main risk factors for Colletotrichum keratitis.…”