Clinical and morphological characteristics of gastrointestinal stromal tumors

Khalikov, Dinar; Akhmetzyanov, F Sh; Петров, С. В.

doi:10.17116/patol201779448-55

Arkh. patol.

2017

DOI: 10.17116/patol201779448-55

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Clinical and morphological characteristics of gastrointestinal stromal tumors

Dinar Khalikov

F Sh Akhmetzyanov²,

С. В. Петров³

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Cited by 4 publications

(1 citation statement)

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“…DOI: 10.24884/0042-4625-2022-181-6-79-82. в в е д е н и е. Несмотря на все разнообразие неэпителиальных опухолей желудочно-кишечного тракта, особую группу составляют гастроинтестинальные стромальные опухоли (GIST, ГИСО), излюбленной локализацией которых являются желудок и тонкая кишка [1]. Данный вид образований характеризуется специфическими иммуногистохимическими, гистологическими и молекулярно-генетическими признаками [2]. Гастроинтестинальные стромальные опухоли относятся к редким опухолям.…”

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Video capsule enteroscopy in the diagnosis of GIST of the ileum

Кортиева¹,

Krushelnitskiy

Габриэль³

et al. 2022

VESTNIK KHIRURGII IMENI I.I.GREKOVA

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The OBJECTIVE was to show the effectiveness of video capsule and balloon-assisted enteroscopy in the diagnosis of gastrointestinal stromal tumor of the ileum.METHODS AND MATERIALS. A clinical observation of a patient with a suspected tumor of the small intestine is presented. During the examination, video capsule endoscopy of the small intestine was performed using the Given Imaging capsule. In the ileum, mucosal infiltration and fresh blood were found. Conclusion: tumor of the small intestine. The patient underwent resection of the ileum with a tumor. Histological conclusion: malignant gastrointestinal stromal tumor with moderate mitotic activity and single metastasis to the mesenteric lymph node.CONCLUSION. The difficulty in diagnosing tumors of the small intestine is due to the lack of specific clinical symptoms and the complexity of visualizing the neoplasm. In such cases, it is advisable to include video capsule enteroscopy in the diagnostic algorithm, which according to indications can be supplemented with balloon-assisted enteroscopy by oral or transanal access.

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unclassified

Video capsule enteroscopy in the diagnosis of GIST of the ileum

Кортиева¹,

Krushelnitskiy

Габриэль³

et al. 2022

VESTNIK KHIRURGII IMENI I.I.GREKOVA

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Immunotherapy of gastrointestinal stromal tumors: current view and future directions

Boichuk,

Abduraeva,

Kopnin

2023

Usp. mol. onkol

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Gastrointestinal stromal tumors (GIST) are most common mesenchymal tumors in gastrointestinal tract which originate from interstitial cells of Cajal and characterized by the mutations in the KIT or PDGFRA tyrosine kinase receptors. Thus, the common therapeutic approach for GIST therapy (including metastatic, recurrent and non-resectable forms) is based on inhibiton of activities of receptor tyrosine kinases indicated above by corresponding receptor tyrosine kinase inhibitors, including first-line therapeutic agent imatinib mesylate – Gleevec. Despite of high efficacy of IM-based therapy, most of GIST patients acquire resistance to this receptor tyrosine kinase inhibitor, which in turn requires second-, third- and fourth-line therapies. The review also describes the common molecular and genetic variants of GIST and the mechanisms of primary and secondary GIST resistance to the targeted-based therapies. In addition, the role of immune microenvironment in GIST and its relationship with tumor’s mutational burden are discussed in detail, thereby illustrating the immunotherapy as one of the attractive future directions for GIST therapy. Lastly, the manuscript provides the information about the ongoing clinical trials of GIST immunotherapy.

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MESENCHYMAL TUMORS OF THE COLON AND RECTUM: DIAGNOSIS, TREATMENT, PROGNOSIS (case report and review)

et al. 2020

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Mesenchymal tumors of the colon and rectum are extremely rare and do not have specific clinical manifestations, their diagnosis and staging cause certain difficulties.Different types of mesenchymal tumors differ in prognosis and choice of the treatment. It explains the importance of differential diagnosis of these neoplasms among themselves and tumors-derivatives of other embryonic structures.The article describes the clinical case of a rare mesenchymal tumor and management of the patient.

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Clinical and morphological characteristics of gastrointestinal stromal tumors

Cited by 4 publications

References 59 publications

Video capsule enteroscopy in the diagnosis of GIST of the ileum

Video capsule enteroscopy in the diagnosis of GIST of the ileum

Immunotherapy of gastrointestinal stromal tumors: current view and future directions

MESENCHYMAL TUMORS OF THE COLON AND RECTUM: DIAGNOSIS, TREATMENT, PROGNOSIS (case report and review)

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