Hereditary hemolytic anemias (HHA) are a heterogeneous group of genetic disorders characterized by increased destruction of circulating red blood cells (RBC), causing mild-to-severe chronic anemia. The intrinsic red cell defects in HHA are due to red cell membrane disorders (membranopathies), red cell enzyme deficiencies (enzymopathies), and hemoglobin disorders (hemoglobinopathies). 1 HHA is clinically characterized by jaundice, recurrent anemia, cholelithiasis, splenomegaly, and hepatomegaly, with variable age at onset and severity. 2,3 In developing countries, HHA is an important cause of morbidity and mortality secondary only to malnutrition and infections. 4 The RBC membrane cytoskeleton is a multiprotein complex that interacts with phospholipid bilayer via vertical and horizontal interactions. The mutation in genes coding for membrane proteins results in a decrease in RBC permeability and impaired RBC deformability.