Clinical and molecular characterization of hemoglobin Maputo [beta 47 (CD6) Asp > Tyr HBB: c.142G > T] and G‐Ferrara [beta 57 (E1) Asn > Lys HBB: c.174C > A] in a newborn screening in Brazil

Comments on: “Clinical, hematological and genetic data of a cohort of children with hemoglobin SD”

“…However, the Brazilian Government Directive MS # 822/01 that regulates newborn screening for hemoglobinopathies, has promoted an increase of data about hemoglobinopathies in different Brazilian regions 9, 10, 11. This associated with the use of isoelectric focusing electrophoresis (IEF) and high-pressure liquid chromatography (HPLC) as diagnostic methods, has enabled the identification of an increasing number of abnormal Hbs as well as compound heterozygous states of Hb S 12, 13, 14. An example is a paper published in this issue of the Revista Brasileira de Hematologia e Hemoterapia that shows data on a cohort of children with hemoglobin SD pattern 15 …”