Clinical and microbiological outcomes of photodynamic and systemic antimicrobial therapy in smokers with peri-implant inflammation

Deeb, Modhi Al; Alsahhaf, Abdulaziz; Mubaraki, Sarah; Alhamoudi, Nawaf; Al‐Aali, Khulud Abdulrahman; Abduljabbar, Tariq

doi:10.1016/j.pdpdt.2019.101587

Cited by 27 publications

(106 citation statements)

References 24 publications

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“…Another short‐term clinical study in 2019 evaluated the performance of adjunctive aPDT in smokers with peri‐implant mucositis. These results have demonstrated that adjunctive aPDT combined with mechanical debridement was effective as adjunctive antibiotic therapy (51). Both treatment (mechanical debridement and aPDT) and positive control (antibiotic) groups experienced a significant decrease in the pocket depth measurement and the growth of peri‐implantitis microorganisms.…”

Section: Clinical Trials and The Effect Of Apdt On Peri‐implantitismentioning

confidence: 96%

Photodynamic Therapy for Biomodulation and Disinfection in Implant Dentistry: Is It Feasible and Effective?

Choe

Balhaddad

Fisher

et al. 2021

Photochem & Photobiology

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Dental implants are the most common rehabilitation and restorative treatment used to replace missing teeth. Biofilms adhere to implant surfaces to trigger implant‐associated infection and inflammatory response. Clinically, the biofilm induces a local host response with the infiltration of phagocytic immune cells. The pro‐inflammatory surroundings set off osteoclastogenesis, which leads to the septic loosening of the implant. The standard of dental care for implant‐associated infection relies on a combination of surgery and antimicrobial therapy. Antimicrobial photodynamic therapy is a noninvasive and photochemistry‐based approach capable of reducing bacterial load and modulating inflammatory responses. In this review, we explore the photobiomodulation and disinfection outcomes promoted by photodynamic therapy for implant infections, highlighting the quality of evidence on the most up‐to‐date studies, and discuss the major challenges on the advance of these therapeutic strategies.

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Section: Clinical Trials and The Effect Of Apdt On Peri‐implantitismentioning

confidence: 96%

Photodynamic Therapy for Biomodulation and Disinfection in Implant Dentistry: Is It Feasible and Effective?

Choe

Balhaddad

Fisher

et al. 2021

Photochem & Photobiology

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“…Non-surgical treatment of peri-implant mucositis: • Alternative measures for biofilm removal (4 RCTs [23][24][25][26]); • Adjunctive diode laser/antimicrobial photodynamic therapy (aPDT) (4 RCTs (5 publications) [27][28][29][30][31]); • Adjunctive local antiseptics (4 RCTs [32][33][34][35]); • Adjunctive systemic antibiotics (2 RCTs [29,36]); • Adjunctive probiotics (2 RCTs [37,38]); • Adjunctive antiseptic home care mouthrinse ).…”

Section: Subdivision Of Selected Studiesmentioning

confidence: 99%

“…In 4 RCTs (5 publications), either antimicrobial photodynamic therapy (aPDT) [27][28][29] or a diode laser [30,31] was used in addition to mechanical debridement. Over a 3-month period, adjunctive use of aPDT led to similar treatment outcomes in terms of BOP [27][28][29] and PD changes [28,29], while 1 study reported on a higher reduction in PD values for the sites treated with adjunctive aPDT [27]. Similarly, the additional application of a diode laser resulted in similar BOP and PD changes compared to the mechanical treatment alone over 3-and 12-month periods [30,31].…”

Section: Adjunctive Diode Laser/apdtmentioning

confidence: 99%

Efficacy of alternative or adjunctive measures to conventional non-surgical and surgical treatment of peri-implant mucositis and peri-implantitis: a systematic review and meta-analysis

2021

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Purpose To evaluate the efficacy of alternative or adjunctive measures to conventional non-surgical or surgical treatment of peri-implant mucositis and peri-implantitis. Material and methods Prospective randomized and nonrandomized controlled studies comparing alternative or adjunctive measures, and reporting on changes in bleeding scores (i.e., bleed0ing index (BI) or bleeding on probing (BOP)), probing depth (PD) values or suppuration (SUPP) were searched. Results Peri-implant mucositis: adjunctive use of local antiseptics lead to greater PD reduction (weighted mean difference (WMD) = − 0.23 mm; p = 0.03, respectively), whereas changes in BOP were comparable (WMD = − 5.30%; p = 0.29). Non-surgical treatment of peri-implantitis: alternative measures for biofilm removal and systemic antibiotics yielded higher BOP reduction (WMD = − 28.09%; p = 0.01 and WMD = − 17.35%; p = 0.01, respectively). Surgical non-reconstructive peri-implantitis treatment: WMD in PD amounted to − 1.11 mm favoring adjunctive implantoplasty (p = 0.02). Adjunctive reconstructive measures lead to significantly higher radiographic bone defect fill/reduction (WMD = 56.46%; p = 0.01 and WMD = − 1.47 mm; p = 0.01), PD (− 0.51 mm; p = 0.01) and lower soft-tissue recession (WMD = − 0.63 mm; p = 0.01), while changes in BOP were not significant (WMD = − 11.11%; p = 0.11). Conclusions Alternative and adjunctive measures provided no beneficial effect in resolving peri-implant mucositis, while alternative measures were superior in reducing BOP values following non-surgical treatment of peri-implantitis. Adjunctive reconstructive measures were beneficial regarding radiographic bone-defect fill/reduction, PD reduction and lower soft-tissue recession, although they did not improve the resolution of mucosal inflammation.

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“…Peri-implantitis is caused by a variety of pathogenic microorganisms and often requires treatment in various ways 1 . Non-surgical or surgical treatment, supplemented by local or systemic drugs, might improve treatment efficacy 2 . Removing and controlling biofilms on the implant are the key to the treatment of the inflammation.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the antibacterial effects and mechanism of Plantaricin 149 from Lactobacillus plantarum NRIC 149 on the peri-implantitis pathogens

Lin

Shi

et al. 2021

Sci Rep

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Peri-implantitis is a common reversible disease after tooth implantation, caused by a variety of pathogenic microorganisms. Based on non-surgical or surgical treatment principles, supplementation by local or systemic drugs might enhance treatment efficacy. Porphyromonas gingivalis (Pg) (ATCC 33,277) and Prevotella intermedius (Pi) (ATCC 25,611) were used as test strains. The effects of Pln 149 on the biofilm formation and growth of four periodontal pathogens were evaluated by RT-PCR, fluorescence microscopy, and scanning electron microscopy. The antibacterial mechanism was tested by the patch-clamp technique. The cytotoxicity of Pln 149 (125 µg/ml) to bone marrow stromal cell (BMSC) was assessed using an MTT assay. Pln 149 exhibited significant inhibitory effects on Pg and Pi (P < 0.05), with significant differences in the biofilm images of fluorescence microscope and scanning electron microscope (P < 0.05). Pln 149 could change the sodium channel currents and exerted no cytotoxicity on bone marrow stromal cell. Pln 149 could inhibit the biofilm formation and growth of periodontal pathogens. Considering the absence of antimicrobial resistance and cytotoxicity, we suggest that the Pln 149 from Lactobacillus plantarum 149 might be a promising option for managing peri-implantitis.

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Clinical and microbiological outcomes of photodynamic and systemic antimicrobial therapy in smokers with peri-implant inflammation

Cited by 27 publications

References 24 publications

Photodynamic Therapy for Biomodulation and Disinfection in Implant Dentistry: Is It Feasible and Effective?

Photodynamic Therapy for Biomodulation and Disinfection in Implant Dentistry: Is It Feasible and Effective?

Efficacy of alternative or adjunctive measures to conventional non-surgical and surgical treatment of peri-implant mucositis and peri-implantitis: a systematic review and meta-analysis

Evaluation of the antibacterial effects and mechanism of Plantaricin 149 from Lactobacillus plantarum NRIC 149 on the peri-implantitis pathogens

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