Clinical and microbiological effects of the initial periodontal therapy

Predin, Tanja; Djuric, M.; Mirnic, Jelena; Gusic, Ivana; Nikolic, Nadja; Marković, Dubravka; Anđelković, Aleksandra; Milašin, Jelena

doi:10.2298/sarh1402010p

Cited by 3 publications

(3 citation statements)

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“…[9][10][11] Furthermore, hitherto clinical experiences also show that the improvement in clinical condition in PD and in CAL, after three, six and twelve months also ensued. [12][13][14][15][16] However, with non-surgical therapy it is impossible to remove all bacteria deposits. For example bacteria from deep unapproachable periodontal pockets or microorganisms from other areas of oral cavity, which are beyond the scope of non-surgical therapy, make results of this therapy to be unpredictable and dependent upon many different factors.…”

Section: Discussion:-mentioning

confidence: 99%

Examine Patients With Chronic Periodontitis in Order to Evaluate the Efficacy of Non - Surgical Therapy and Combination of Amoxicillin and Metronidazole Compared With Cefixime

Begum¹,

M.S²

2020

IJAR

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Background: Periodontal diseases are inflammatory reactions that affect the supporting tissues of the teeth, which consist of Gingiva, periodontal ligament, root cementum and alveolar bone. The third generation of cephalosporinscefixime (CEF), which is an antibiotic with wide spectrum of effect on Gram-positive and Gramnegative bacteria, was used in cases of oral infections. Objective: The aim of the study to evaluate the efficacy of non-surgical therapy and combination of amoxicillin and metronidazole compared with cefixime. Methods: The clinical study was conducted at the Department of Periodontology, Clinic for Dentistry of the Khulna Medical College. In order to assess the condition of periodontium, we used the level of gingival inflammation which is expressed through gingival index (GI) according to Loe and Silness, bleeding on probe (BOP), according to Mühlemann and Son, probing depth (PD) and clinical attachment level (CAL). Results: In control group, mean gingival index, bleeding on probing and probing pocket depth were statistically significantly (p<0.05) when compare between day 0 vs day 7. In AMO-MET group, mean gingival index, bleeding on probing and probing pocket depth were statistically significantly (p<0.05) when compare between day 0 vs day 7. In cefixime mean gingival index, bleeding on probing and probing pocket depth were statistically significantly (p<0.05) when compare between day 0 vs day 7. After seventh day, mean bleeding on probing and probing pocket depth were statistically significantly when compared between control vs AMO-MET and control vs cefixime group. Conclusion: Mean bleeding on probing and probing pocket depth was statistically significantly when compared between control vs AMO-MET and control vs cefixime group.

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Section: Discussion:-mentioning

confidence: 99%

Examine Patients With Chronic Periodontitis in Order to Evaluate the Efficacy of Non - Surgical Therapy and Combination of Amoxicillin and Metronidazole Compared With Cefixime

Begum¹,

M.S²

2020

IJAR

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“…When co-cultivated with macrophages and epithelial cells T. f. causes the release of anti-inflammatory cytokines, chemokines, prostaglandins E. It takes about 12 days to cultivate a small colony of bacteria. Studies have shown that this periodontopathogen is found in patients with periodontitis that did not respond to treatment ( 42 ).…”

Section: Introductionmentioning

confidence: 99%

The influence of microbiota on the development and course of inflammatory diseases of periodontal tissues

Demkovych,

Kalashnikov,

Hasiuk

et al. 2023

Front. Oral. Health

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An important feature of the functioning of the organs and tissues of the oral cavity is the fact that all processes that take place in it are carried out in the constant presence of various microorganisms that cause the development of pathological processes in the body or are associated with them. In the pathogenesis of chronic generalized periodontitis, dental plaque penetrates the bottom of the gingival sulcus, penetrating under the epithelium into the stroma of the connective tissue, causing its inflammation. Bacteria produce a number of toxic substances that have a toxic effect on surrounding tissues. Most bacteria produce chain fatty acids that inhibit chemotaxis of leukocytes and phagocytes. Anaerobes and spirochetes secrete a number of substances (propionic acid and indole) that are extremely toxic to most tissues. Inflammation in the periodontal tissues is caused by the microbiota of the dental plaque biofilm. As periodontitis develops, an increase in the number of P. gingivalis, P. intermedia and T. forsythia was found in it, more than 100 times. Therefore, the given data prove that in the development and course of the inflammatory process in the periodontal tissues, complex dysbiotic and tissue-cellular interactions are involved, the dynamic balance of which depends on its outcome.

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“…Periodontal pathogens are commensal, resident flora in periodontal micro‐ecological environments, and can be isolated from subgingival plaque from both healthy individuals and those with periodontitis 7 . Mechanical therapy can reduce the amount of bacteria; however, major pathogens can escape the treatment process, as the instruments used cannot access infected regions, especially the furcation area 8 . Subsequently, pathogens recolonize periodontal pockets and return to the pre‐treatment levels 9 .…”

Section: Introductionmentioning

confidence: 99%

The sialidase inhibitor, DANA, reduces Porphyromonas gingivalis pathogenicity and exerts anti‐inflammatory effects: An in vitro and in vivo experiment

Fan

Zheng

et al. 2020

Journal of Periodontology

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Background Sialidase has an important role in the pathogenesis of periodontitis and Porphyromonas gingivalis is a sialidase‐producing organism implicated in periodontitis development. The aim of this study was to evaluate the anti‐virulence and anti‐inflammatory properties of the sialidase inhibitor, 2‐deoxy‐2,3‐didehydro‐N‐acetylneuraminic acid (DANA), in vitro and in vivo. Methods The effects of DANA on P. gingivalis sialidase and cell viability were determined, and the effects of DANA on P. gingivalis virulence were evaluated by assessment of growth curves, cell morphology, biofilm formation, fimbriae gene expression, and gingipains and lipopolysaccharide (LPS) activity. Anti‐inflammatory effects of DANA on LPS‐induced macrophages were assessed by measurement of tumor necrosis factor‐alpha (TNF‐α), interleukin (IL‐1β), inducible nitric oxide synthase (iNOS) secretions. The effect of DANA on P. gingivalis–induced periodontitis in rats was analyzed by radiography, stereoscopic microscopy, histopathology, and immunohistochemistry. Results Sialidase inhibition rate of 1mM DANA was 72.01%. Compared with untreated controls, treatment with DANA inhibited P. gingivalis growth and biofilm formation, and significantly decreased expression of the fimA, fimR, and fimS genes, as well as gingipains activity. DANA did not influence macrophage viability, but significantly inhibited TNF‐α, IL‐1β, and iNOS production in LPS‐stimulated macrophages. In the periodontitis rat model, DANA prevented alveolar bone absorption and inhibited TNF‐α and IL‐1β production. Conclusion DANA can reduce the growth, the biofilm formation and the virulence of P. gingivalis and exhibits anti‐inflammatory effects, as well as effects against rat periodontitis, suggesting that DANA should be considered for development as a new adjunctive treatment for periodontitis.

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Clinical and microbiological effects of the initial periodontal therapy

Abstract: The results of the present study demonstrated the beneficial effects of the initial periodontal therapy on both the clinical and microbiological parameters.

Cited by 3 publications

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Examine Patients With Chronic Periodontitis in Order to Evaluate the Efficacy of Non - Surgical Therapy and Combination of Amoxicillin and Metronidazole Compared With Cefixime

Examine Patients With Chronic Periodontitis in Order to Evaluate the Efficacy of Non - Surgical Therapy and Combination of Amoxicillin and Metronidazole Compared With Cefixime

The influence of microbiota on the development and course of inflammatory diseases of periodontal tissues

The sialidase inhibitor, DANA, reduces Porphyromonas gingivalis pathogenicity and exerts anti‐inflammatory effects: An in vitro and in vivo experiment

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