Clinical and Microbiologic Study of Periodontitis Associated With Kindler Syndrome

Abstract

In the Kindler group, periodontitis had an onset in early teenage years and progressed more rapidly compared to non-Kindler individuals of the same geographic and ethnic group. Clinical and microbiological findings suggest atypical periodontitis in Kindler patients. We propose to include Kindler syndrome in the category of medical disorders predisposing to destructive periodontal disease.

Kindler Syndrome and Periodontal Disease: Review of the Literature and a 12‐Year Follow‐Up Case

“…The association of aggressive periodontitis with Kindler syndrome (KS) was proposed based on a single case in 1996 and later confirmed with a larger population of patients 1,2 . KS is an autosomal recessive disorder ‡ that was first described in 1954 by Dr. Theresa Kindler 3 .…”

A Very Rare Case of Kindler Syndrome

“…Syndactyly, sclerotic bands of the wrists 10 , nail dystrophy, ectropion of the lower lid, multiple stromal nebular corneal opacities, thickened corneal nerves 11 , palmoplantar keratoderma, pseudoainhum, leucokeratosis of the lips and oral mucosa, xerostomia 12 , dental caries and atypical periodontitis with earlier onset and more rapid progression 13 , squamous cell carcinoma 14 , hypohidrosis, phimosis, skeletal abnormalities 15 , such as dome-shaped skull, bifid or missing ribs and mandibular abnormalities may be also observed.…”

Oral Health Care for Patients with Epidermolysis Bullosa ‐ Best Clinical Practice Guidelines

“…Only few case reports of patients with Kindler syndrome describe their oral features 34,[85][86][87][88][89][90] . The evidence suggests that patients with Kindler syndrome can present with fragile mucosa, microstomia, and partial vestibule obliteration, although microstomia was not identified in all patients with Kindler syndrome 34,85,86 . Special attention has been given to periodontal disease, which was initially reported in two patients 34,88 .…”

“…Special attention has been given to periodontal disease, which was initially reported in two patients 34,88 . Thereafter, a series of 18 patients was compared to healthy controls, revealing that patients with Kindler syndrome have a higher prevalence (72% vs 46%), earlier onset, and faster progression of periodontitis 85 . Squamous cell carcinoma of the hard palate has also been reported in a patient with this condition 86 .…”